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Professor Nick Curzen BM (Hons), PhD, FRCP

Chair of Interventional Cardiology, Consultant Cardiiologist

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Professor Nick Curzen is Consultant Cardiologist within Medicine at the University of Southampton.

Research

Responsibilities

Publications

Contact

Research interests

Nick Curzen BM(Hons) PhD FRCP is Professor of Interventional Cardiology at the University of Southampton and Consultant Cardiologist at University Hospital Southampton NHS Trust.

Nick undertakes both coronary intervention and TAVI. He has an active research team: he is Chief Investigator for 2 large randomised trials in the UK: RIPCORD 2 and FORECAST. In the past he was Chief Investigator for RIPCORD 1, FFRCT RIPCORD and COMET. Nick has led a platelet function research team for over 10 years looking at personalised antiplatelet medication and has published widely in this field using TEG 5000. More recently, the team has just finished a validation study for TEG 6S and has been involved in the discussions about PROPHECI. He has an active longstanding collaboration with Prof. Neil Bressloff, Professor of Biomedical Design and Engineering at the University of Southampton. Together they have co-supervised 3 PhD students looking at computer models of coronary stent and TAVI deployment and work together as CARENA Healthcare to design novel solutions in TAVI and coronary intervention. See also FutureWorlds Carena Healthcare.

Nick has published over 200 PubMed papers & edited 3 textbooks, including the Oxford textbook of Interventional Cardiology. His Coronary Research Group have attracted over £4m of research funding in the last 15 months. He is currently supervising 2 MD and 2 PhD students and regularly supervises BMedSci and MMedSci medical students. His bid for an NIHR Clinical Academic Fellowship has just been successful.

Department(s)

Human Development and Health

Affiliate Department(s)

Human Development and Physiology

Research project(s)

Coronary Artery Stent Design for Challenging Disease

In treating coronary artery disease with percutaneous coronary intervention, stent malapposition is to be avoided. The focus here is to design stents that minimise malapposition in challenging disease.

Towards Prediction of Paravalvular Leakage and Leaflet Stress Following Deployment of a Balloon-Expandable Transcutaneous Aortic Valve Implantation (TAVI) Device in Critical Aortic Stenosis: A Computer Simulation Model

To construct a computer model of a state of the art TAVI device to simulate deployment in a diseased native valve in order to assess the factors associated with paravalvular leakage (PL) and the stresses in the implant leaflets, with a view to formulating beneficial modification.

National responsibilities

Expert adviser to NICE appraisals of ticagrelor and prasugrel on behalf of British Cardiovascular Society (BCS), British Cardiovascular Intervention Society (BCIS) & Royal College of Physicians 2009-11

Expert nominated by British Cardiovascular Society for NICE guidance on Acute Coronary Syndromes 2009

BCIS & BCS nominated expert adviser in NICE Technology Appraisal of Ticagrelor in Acute Coronary Syndromes 2010-11

Honorary Secretary of British Cardiovascular Intervention Society (BCIS) elected December 2010

Invited member of expert review panel for Department of Health Cardiac Technology Horizon Scanning Project 2010

Clinical Lead for Royal College of Physicians Map of Medicine pathway review for ACS and stable angina for the Department of Health 2008-11

Member of national BCIS Research Committee 2009-present

Specialist Adviser to NICE Interventional Procedures Programme as representative to British Cardiac Society 2009-

International responsibilities

UK Representative on European Association for Percutaneous Coronary Intervention Accreditation Training Committee 2008-present

Invited faculty member to Transcatheter Therapeutics (TCT) Conferences (Washington DC) 2006-11

Invited member of faculty to European Society of Cardiology Conference 2009 (Barcelona)

Invited Faculty member to PCR Conferences 2006-11 (Paris)

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Articles

Book Chapter

Curzen, N. (2007). Thrombosis in cardiovascular disease. In H. Gray, K. Dawkins, J. Morgan, & I. Simpson (Eds.), Lecture Notes Cardiology, 5th Edition (pp. 119-127). (Lecture Notes Series; No. Chapter 7). Blackwell.

Conferences

Curzen, N., Rana, O., Golledge, P., Zaman, A., Oldroyd, K., Hanratty, C., Banning, A., Hildick-Smith, D., Dimitrov, B. D., Calver, A., Nicholas, Z., & Corbett, S. (2013). Does routine pressure wire assessment influence management strategy at coronary angiography for diagnosis of chest pain? The RIPCORD Study. Paper presented at Late Breaking Trials at EuroPCR 2013, France.
Torrens, C., Anthony, F. W., Kelsall, C. J., Curzen, N., & Hanson, M. A. (2007). Statin treatment corrects endothelial dysfunction but not markers of inflammation in offspring of protein restricted dams. Early Human Development, 83(Supplement 1), p.S60. https://doi.org/10.1016/S0378-3782(07)70099-3

Letters/Editorials

T-TIME Group, Maznyczka, A. M., McCartney, P. J., Eteiba, H., Greenwood, J. P., Muir, D. F., Chowdhary, S., Gershlick, A. H., Appleby, C., Cotton, J. M., Wragg, A., Curzen, N., Oldroyd, K. G., Lindsay, M., McEntegart, M., Rocchiccioli, J. P., Shaukat, A., Good, R., Watkins, S., ... Berry, C. (2020). One-year outcomes after low-dose intracoronary alteplase during primary percutaneous coronary intervention: The T-TIME Randomized Trial. Circulation. Cardiovascular interventions, 13(2), [e008855]. https://doi.org/10.1161/CIRCINTERVENTIONS.119.008855
Mariathas, M., & Curzen, N. (2019). Use of troponins in clinical practice: Evidence against the use of troponins in clinical practice. Heart. https://doi.org/10.1136/heartjnl-2019-315765
Mamas, M. A., & Curzen, N. (2018). Hobson's choice: platelet inhibition and thrombocytopenia. Circulation: Cardiovascular Interventions, 11(4), 1-3. [e006577]. https://doi.org/10.1161/CIRCINTERVENTIONS.118.006577
Mariathas, M., & Curzen, N. (2018). Troponin assays: developing indications. Lancet (London, England), 391(10138), 2398-2399. https://doi.org/10.1016/S0140-6736(17)32342-5
Piroth, Z., Toth, G. G., Tonino, P. A. L., Barbato, E., Aghlmandi, S., Curzen, N., Rioufol, G., Pijls, N. H. J., Fearon, W. F., Jüni, P., & De Bruyne, B. (2017). Response by Piroth et al to letter regarding article, "Prognostic Value of Fractional Flow Reserve Measured Immediately After Drug-Eluting Stent Implantation". Circulation. Cardiovascular interventions, 10(10), [e005973]. https://doi.org/10.1161/CIRCINTERVENTIONS.117.005973

Report

McCann, G. P., Khan, J. N., Greenwood, J. P., Nazir, S. A., Dalby, M., Curzen, N., Hetherington, S., Kelly, D. J., Blackman, D. J., Ring, A., Peebles, C., Wong, J., Sasikaran, T., Flather, M., Swanton, H., & Gershlick, A. H. (2016). The randomised Complete versus Lesion-only PRimary percutaneous coronary Intervention Trial: Cardiovascular Magnetic Resonance imaging substudy (CvLPRIT-CMR). (EME Journal Series; Vol. 3, No. 1). NIHR Journals Library. https://doi.org/10.3310/eme03010

Reviews

Professor Nick Curzen
E Level North Wing University Hospital Southampton NHS Foundation Trust Southampton SO16 6YD Email: nick.curzen@uhs.nhs.uk Tel: +44 (0)23 8120 4972

Room Number: SGH/ED217C D Level East Wing

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