View all research projects

Research project

Boche - ARUK - Locus coeruleus: its role in cortical and subcortical inflammation in Alzheimer's disease

Research groups:

Clinical Neurosciences
Lead researcher:

Professor Delphine Boche
Other researchers:

Emeritus Professor Clive Holmes
Research funder:

Alzheimers Research UK
Status:

Not active

Staff

Lead researcher

Professor Delphine Boche

Professor Delphine Boche

Professor of Neuroimmunopathology

Research interests

Delphine serves on a range of neuroscience research projects focusing on neuroinflammation and neurodegeneration.
Her main research interest is to develop a greater understanding of the role of neuroinflammation in relation with ageing, neurological diseases and systemic inflammation, using the approaches of human brain analysis. Her research focuses on microglia, the immune cells of the brain, where she has developed protocols to immunophenotype microglia in humans using markers relating to a specific function allowing us to investigate the role of these cells in different neurological conditions.
Her work is located at the junction between clinical neurodegenerative disease, human neuropathology and experimental neuroscience where she has developed an expertise in neuroimmunopathology

Email: d.boche@soton.ac.uk

Other researchers

Emeritus Professor Clive Holmes

Emeritus Professor Clive Holmes

Email: c.holmes@soton.ac.uk

Collaborating research institutes, centres and groups

Clinical Neurosciences

Examining how clinical and environmental factors can affect brain development.

Research outputs

Neuropathology of the Locus Coeruleus in Alzheimer's disease

Rebecca Claire Beardmore

, 2022

Type: thesis

The locus coeruleus in aging and Alzheimer’s Disease: a postmortem and brain imaging review

Rebecca C Beardmore,

Ruihua Hou,

Angela Darekar,

Clive Holmes,

& Delphine Boche

, 2021 , Journal of Alzheimer's Disease , 83 (1) , 5--22

DOI: 10.3233/JAD-210191

Type: review

Back to top