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Research project

D Boche: High throughput and high resolution digital slide scanner Nanozoomer

Staff

Lead researcher

Professor Delphine Boche

Professor of Neuroimmunopathology

Research interests

  • Delphine serves on a range of neuroscience research projects focusing on neuroinflammation and neurodegeneration.
  • Her main research interest is to develop a greater understanding of the role of neuroinflammation in relation with ageing, neurological diseases and systemic inflammation, using the approaches of human brain analysis. Her research focuses on microglia, the immune cells of the brain, where she has developed protocols to immunophenotype microglia in humans using markers relating to a specific function allowing us to investigate the role of these cells in different neurological conditions.
  • Her work is located at the junction between clinical neurodegenerative disease, human neuropathology and experimental neuroscience where she has developed an expertise in neuroimmunopathology

Research outputs

Immune environment of the brain in schizophrenia and during the psychotic episode: a human post-mortem study
Livia De Picker,
Gerardo Mendez-Victoriano,
Rhys Richards,
Alexander Gorvett,
Simeon Lyons,
George Buckland,
Tommaso Tofani,
Jeanette Norman,
David Chatelet,
James Nicoll,
& Delphine Boche
, 2021 , Brain, Behavior and Immunity , 97 , 319--327
DOI: 10.1016/j.bbi.2021.07.017
Type: review
Persistent neuropathological effects 14 years following amyloid-β immunisation in Alzheimer’s disease
James A.R. Nicoll,
George R. Buckland,
Charlotte H. Harrison,
Anton Page,
Scott Harris,
Seth Love,
James W. Neal,
Clive Holmes,
& Delphine Boche
, 2019 , Brain , 142 (7) , 2113--2126
DOI: 10.1093/brain/awz142
Type: article
Microglial motility in Alzheimer’s disease and after Aβ42 immunotherapy: a human post-mortem study
Diana, Karina Franco Bocanegra,
Bethany George,
Laurie C. Lau,
Clive Holmes,
James A.R. Nicoll,
& Delphine Boche
, 2019 , Acta Neuropathologica Communications , 7 (1) , 174
DOI: 10.1186/s40478-019-0828-x
Type: article
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