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Research project

Dr P Howarth: 'Wessex severe asthma cohort'

Staff

Other researchers

Professor Donna Davies

Prof in Resp. Cell & Molecular Biology

Research interests

  • Mechanisms of lung diseases
  • Viral-induced exacerbations of lung disease

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Professor Ratko Djukanovic

Professor of Medicine

Research interests

  • Professor Djukanovic has a lifelong interest in asthma, especially its severe forms. where his focus is on: 1) underlying pathobiological mechanisms of asthma, 2) stratification of asthma into clinical phenotypes and mechanism-based endotypes, 3) unmet needs of severe asthma management. He also has an interest in the mechanisms and treatments of severe viral infections of the lung.
  • Underlying mechanisms of asthma: Professor Djukanovic has conducted pioneer studies into the pathology of asthma, applying research bronchoscopy  (with endobronchial biopsy and bronchoalveolar lavage) and sputum induction. He led the initial task forces which defined the use of these two techniques, thereby paving the way for standardised research approches that enabled in-depth descriptions of the roles of various inflammatory cells and their mediators. He developed an explant model, consisting of bronchial biopsies placed into tissue culture, that could be stimulated ex vivo with relevant triggers, applying as needed, novel agents not yet approved for in vivo use in humans volunteers. 

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Research outputs

Soluble ADAM33 initiates airway remodeling to promote susceptibility for allergic asthma in early life
Elizabeth R. Davies,
Joanne F. Kelly,
Peter H. Howarth,
David Wilson,
Stephen Holgate,
Donna E. Davies,
Jeffrey A. Whitsett,
& Hans Michael Haitchi
, 2016 , JCI Insight , 1 (11) , 1--16
DOI: 10.1172/jci.insight.87632
Type: article
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