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Research project

Evaluating the efficacy of Enhancer of Zeste Homolog 2 (EZH2) inhibitors in combination with anti- GD2/isotretinoin for the treatment of high-risk neuroblastoma: a pre-clinical study

Project overview

The overall purpose of my research work is to investigate a novel combination of agents to improve the outcome of children with high-risk neuroblastoma. Specifically, we will utilise established pre-clinical models to investigate whether the efficacy of anti-GD2 and isotretinoin in neuroblastoma can be enhanced by the addition of EZH2 inhibitors, obtaining data to support the translation into clinical trials.

Staff

Lead researcher

Dr Zoë Walters

Associate Professor

Research interests

  • Target Prioritisation and Validation
  • Epigenetics and genomics
  • Cancer 
Connect with Zoë
Other researchers

Professor Juliet Gray

Professor

Research interests

  • Fc modification of monoclonal antibodies to improve effector function
Connect with Juliet

Research outputs