Research project

Lewis - BBSRC - BB/L020823/1 Coupling of organic anion transport to the glutamate gradient by OATs and OATPs

Lead researcher:

Professor Rohan Lewis
Other researchers:

Doctor Bram Sengers
Research funder:

Biotechnology & Biological Sciences Research Council
Status:

Not active

Project overview

This study investigated how the placenta cleans fetal blood removing wastes and toxins as well as medicines that may have reached the fetus from the mother.

Staff

Lead researcher

Professor Rohan Lewis PhD, FTPS

Prof of Placental&Integrative Physiology

Connect with Rohan

Email: rohan.lewis@soton.ac.uk

Other researchers

Doctor Bram Sengers

Associate Professor

Connect with Bram

Email: b.g.sengers@soton.ac.uk

Research outputs

Ursodeoxycholic acid inhibits uptake and vasoconstrictor effects of taurocholate in human placenta

Emma M Lofthouse,

Christopher Torrens,

Antigoni Manousopoulou,

Monica Nahar,

Jane K. Cleal,

Ita M O'Kelly,

Bram G. Sengers,

Spiros D. Garbis,

& Rohan M Lewis

, 2019 , The FASEB Journal , 33 (7) , 8211--8220

DOI: 10.1096/fj.201900015RR

Type: article

A systems perspective on placental amino acid transport

Jane K. Cleal,

Emma M. Lofthouse,

Bram G. Sengers,

& Rohan M. Lewis

, 2018 , The Journal of Physiology , 596 (23) , 5511--5522

DOI: 10.1113/JP274883

Type: review

Glutamate cycling may drive organic anion transport on the basal membrane of human placental syncytiotrophoblast

Emma Lofthouse,

S. Brooks,

J. Cleal,

M. Hanson,

K. Poore,

Ita O'Kelly,

& R. Lewis

, 2015 , The Journal of Physiology , 593 (20) , 4549--4559

DOI: 10.1113/JP270743

Type: article