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Research project

Modelling retinitis pigmentosa associated cone photoreceptor death using stem cell derived organoids

  • Lead researcher:
    Dr Jorn Lakowski
  • Research funder:
    The Academy of Medical Sciences
  • Status:
    Not active

Staff

Lead researcher

Dr Jorn Lakowski

Lecturer

Research interests

  • Retinal Disease Modelling
  • Retinal Development
  • Drug Screening

Research outputs

Microtubule modification defects underlie cilium degeneration in cell models of retinitis pigmentosa associated with pre-mRNA splicing factor mutations
Liliya Nazlamova,
Suly Saray Villa Vasquez,
Jenny Lord,
Varshini Karthik,
Man Kim Cheung,
Jörn Lakowski,
& Gabrielle Wheway
, 2022 , Frontiers in Genetics , 13 , 1009430
DOI: 10.3389/fgene.2022.1009430
Type: article
Generation of a cone photoreceptor-specific GNGT2 reporter line in human pluripotent stem cells
Liliya Nazlamova,
Emma Jane Cassidy,
Jane C. Sowden,
Andrew Lotery,
& Jörn Lakowski
, 2022 , Stem Cells , 40 (2) , 190--203
DOI: 10.1093/stmcls/sxab015
Type: article
NRL−/− gene edited human embryonic stem cells generate rod‐deficient retinal organoids enriched in S‐cone‐like photoreceptors
Elisa Cuevas,
Daniel L. Holder ,
Ashwak H. Alshehri ,
Julie Tréguier ,
Jorn Lakowski,
& Jane C. Sowden
, 2021 , Stem Cells , 39 (4) , 414--428
DOI: 10.1002/stem.3325
Type: article
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