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Research project

BBSRC Alcohol Dependence

Project overview

Using C elegans to identify molecular determinants of ethanol intoxication and withdrawal.

Staff

Lead researcher

Professor Lindy Holden-Dye BSc, MSc, PhD, FRSB, FBPhS

PROFESSOR OF NEUROSCIENCES

Research interests

  • Neuropharmacology
  • Invertebrate neuroscience
  • Nematode neurobiology
Other researchers

Dr Steven Glautier

Associate Professor

Professor Vincent O'connor

Professor of Neurochemistry

Research interests

  • Molecular mechanism of synaptic function and dysfunction
  • Synaptic degeneration
  • Genetic models of synaptic and neuronal dysfunction

Research outputs

NeuroChip: a microfluidic electrophysiological device for genetic and chemical biology screening of Caenorhabditis elegans adult and larvae
Chunxiao Hu,
James Dillon,
James Kearn,
Caitriona Murray,
Vincent O'Connor,
Lindy Holden-Dye,
& Hywel Morgan
, 2013 , PLoS ONE , 8 (5) , e64297--[17pp]
DOI: 10.1371/journal.pone.0064297
Type: article
Distinct molecular targets including SLO-1 and gap junctions are engaged across a continuum of ethanol concentrations in Caenorhabditis elegans
James Dillon,
Ioannis Andrianakis,
Richard Mould,
Ben Ient,
Wei Liu,
Christopher James,
Vincent O'Connor,
& Lindy Holden-Dye
, 2013 , The FASEB Journal , 27 (10) , 4266--4278
DOI: 10.1096/fj.11-189340
Type: article
HSP-4 endoplasmic reticulum (ER) stress pathway is not activated in a C. elegans model of ethanol intoxication and withdrawal
Ben Ient,
Richard Edwards,
Richard Mould,
Matthew Hannah,
Lindy Holden-Dye,
& Vincent O'Connor
, 2012 , Invertebrate Neuroscience
DOI: 10.1007/s10158-012-0136-7
Type: article
A differential role for neuropeptides in acute and chronic adaptive responses to alcohol: behavioural and genetic analysis in caenorhabditis elegans
Philippa Mitchell,
Richard Mould,
James Dillon,
Steven Glautier,
Ioannis Andrianakis,
Christopher James,
Amanda Pugh,
Lindy Holden-Dye,
Vincent O'Connor,
& Anne C. Hart
, 2010 , PLoS ONE , 5 (5) , e10422
DOI: 10.1371/journal.pone.0010422
Type: article
AutoEPG: software for the analysis of electrical activity in the microcircuit underpinning feeding behaviour of caenorhabditis elegans
James Dillon,
Ioannis Andrianakis,
Kate Bull,
Steve Glautier,
Vincent O'Connor,
L. Holden-Dye,
& C.J. James
, 2009 , PLoS ONE , 4 (12) , 1--13
DOI: 10.1371/journal.pone.0008482
Type: article
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