Research project

Role of autophagy in oncogenic RAS-induced invasive behaviour

Research groups:
Lead researcher:

Dr Yihua Wang
Research funder:

Royal Society
Status:

Not active

Project overview

Autophagy, a key survival mechanism allowing cells to tolerate stress or lack of nutrients, promotes tumourigenesis, in particular in RAS-mutated cancer. We demonstrated that elevated autophagy activity bypasses oncogenic RAS-induced senescence in order to support tumour growth (PNAS 2012). This project aims to comprehensively study the role of autophagy in oncogenic RAS-induced tumour invasion.

Staff

Lead researcher

Dr Yihua Wang

Associate Professor

Research interests

Cell Signalling in Disease
Epithelial-Mesenchymal Crosstalk
Pulmonary Fibrosis

Email: yihua.wang@soton.ac.uk

Collaborating research institutes, centres and groups

Cell and Developmental Biology

We explore how molecular interactions between proteins and small molecules, defined at atomic resolution, govern biochemical output and in turn control cell behaviour.