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Research project

Role of autophagy in oncogenic RAS-induced invasive behaviour

  • Research groups:
  • Lead researcher:
  • Research funder:
    Royal Society
  • Status:
    Not active

Project overview

Autophagy, a key survival mechanism allowing cells to tolerate stress or lack of nutrients, promotes tumourigenesis, in particular in RAS-mutated cancer. We demonstrated that elevated autophagy activity bypasses oncogenic RAS-induced senescence in order to support tumour growth (PNAS 2012). This project aims to comprehensively study the role of autophagy in oncogenic RAS-induced tumour invasion.

Staff

Lead researcher

Dr Yihua Wang

Associate Professor

Research interests

  • Cell Signalling in Disease
  • Epithelial-Mesenchymal Crosstalk
  • Pulmonary Fibrosis
Connect with Yihua

Collaborating research institutes, centres and groups

Research outputs