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Research project

The BLIS study

Project overview

The BLIS study: a feasibility study assessing compliance, acceptability and colonisation with different dosing regimens of the probiotic supplement Streptococcus salivarius K12 (Bactoblis®) in adults.

Sore throat due to infection of the throat or tonsils (tonsillitis) is a very common reason for people visit their GP. Many will receive antibiotics, however antibiotic resistance is becoming a major problem, and we need to find ways to prevent sore throat or tonsillitis without using antibiotics.

Recent studies have shown that a probiotic supplement called S. salivarius K12 (Bactoblis®), containing ‘good’ bacteria may be able to prevent tonsillitis. These probiotic supplements have been tested in many studies (involving over 2400 children and adults), and all these studies have shown that they are safe.

Bactoblis® is now able to be bought commercially in many countries, and we would like to find out how effectively the probiotics work and the best dose to take in order to prevent tonsillitis. These results will help us design a large clinical trial in the future, to test how effective it is at preventing tonsillitis.

You can read more about our study on our website:

The research has received funding from the University of Southampton Biomedical Research Centre, Southern Health, and Bluestone Pharma. The study is sponsored by the University of Southampton, and is being conducted by the Primary Care Research Centre and the Southampton NIHR Clinical Research Facility.


Lead researcher

Professor Paul Little

Professor in Primary Care Research

Collaborating research institutes, centres and groups