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Research project

Therapeutic targeting of a novel myeloid immune-checkpoint to overcome chemoresistance in breast cancer

Staff

Lead researcher

Dr Ali Roghanian PhD, FHEA

Associate Professor

Research interests

  • Cancer immunotherapy
  • Monoclonal antibodies
  • Immunoinhibitory receptors
Other researchers

Professor Stephen Beers

Professor of Immunology & Immunotherapy

Research interests

  • Edit
  • Antibody Effector Functions Monoclonal antibodies (mAb) have become established in the treatment of a variety of malignancies - transforming patient outcomes. Despite this undoubted impact, responses remain variable and their mechanisms of action and of tumour resistance are controversial. Our research is focussed on understanding these complex processes using a variety of complementary models and systems to better inform antibody selection, design and clinical application.
  • Current research interests:

Dr Matthew Rose-Zerilli BSc (Hons), PhD

Lecturer in Integrative Cancer Biology

Research interests

  • Cancer geneticsClonal evolutionTumour ecosystems
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