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The University of Southampton
Biological Sciences

Research project: Role of autophagy in oncogenic RAS-induced invasive behaviour

Currently Active: 
Yes
Project type: 
Grant

Autophagy, a key survival mechanism allowing cells to tolerate stress or lack of nutrients, promotes tumourigenesis, in particular in RAS-mutated cancer. We demonstrated that elevated autophagy activity bypasses oncogenic RAS-induced senescence in order to support tumour growth (PNAS 2012). This project aims to comprehensively study the role of autophagy in oncogenic RAS-induced tumour invasion.

I aim to identify new players within the autophagy machinery involved in oncogenic RAS-induced invasion and metastasis. This will not only illuminate how it works but also will provide molecular markers – so called biomarkers – that could be used in the oncology clinic to help identify which cancer patients should be treated more aggressively and which less so. Also, an understanding of how specific players cause the changes, opens the exciting possibility of being able to alter their function with drugs thereby offering some protection against cancers that are prone to aggressive growth.

Funding: Royal Society
Funding Duration: 1st October 2016-30th September 2017

Related research groups

Biomedical Sciences
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