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The University of Southampton
Health Sciences
Phone:
(023) 8120 6559
Email:
bashir@soton.ac.uk

Professor Bashir A Lwaleed PhD, FRCPath, PGCAP, FHEA, CBiol FSB, FIBMS

Professor

Professor Bashir A Lwaleed's photo

Professor Bashir Lwaleed is Professor of Experimental Pathology, Director of Post Graduate Research, and PhD and DClinP Programmes Lead within the School of Health Sciences at the University of Southampton.

I am a Fellow of the Royal College of Pathologists (FRCPath) since 2008 and have held a PhD in haematology since 1998. I am also a Fellow of the Institute of Biomedical Sciences, a Chartered and Fellow of the Society of Biologist, a Member of the British Society for Haematology, the British Society of Haemostasis and Thrombosis.

My academic origins lie in academic and clinical haematology, first in Libya, then in the UK, my career subsequently becoming entirely academic. This adds up to more than 27 years of experience in university healthcare environments.

My research studentship and postdoctoral career has been within the research community of Southampton University Medical School. In 1999 I moved departments from Haematology to Urology at Southampton University Hospitals, research activity later extending to collaboration with Portsmouth University. In 2004 I joined Health Sciences, with a remit to raise the basic and translational research profile of the group as well as expanding its teaching programme. I am an experienced communicator with >155 publications and research presentations, across disciplinary boundaries, from haematology to cancer cell biology and urinary bladder pathologies.

An extension of this interest in communication is the collaborative links forged with academic departments in Brazil, China and South Africa as well as Europe. My research interactions include links to industry with contributions to diagnostic kit development and three patent applications; two published, one filed pending publication.

I have guest-edited issues of the journal Seminars in Thrombosis and Hemostasis. I also act as the Editor-in-Charge for the journal of Advances in Haematology and have written editorials and contributed a haematological chapter for a neonatology book. I serve on the editorial board of a number of international journals and review for several journals/publishers and major charitable and governmental grant-awarding bodies.

Research interests

I undertake collaborative research with the following groups:

  1. Faculty of Pharmacy and Biomedical Sciences, University of Portsmouth, Portsmouth, UK
  2. Clinical and Toxicological Department, Faculty of Pharmacy, Federal University of Minas Gerais, Brazil
  3. Institute of Molecular Sciences, University of Paris-Sud, Orsay, France
Research interest

I have multiple interests in basic, clinical and translational research in the following areas:

Bladder pathology
The bladder wall is continually stretching and relaxing. In chronic catheterization with continual drainage this motility is absent. We hope to determine whether cyclical stretching per se is important for bladder health. The work is funded by the Stuart Halley Trust and involves measuring cytokines present in blood and urine. From subjects with and without indwelling catheters.

Medicinal chemistry of honey
Building on work investigating the effects of honey products on cell physiology and wound healing, we have turned our attention to its potential as an intravesical therapeutic agent for interstitial cystitis/painful bladder syndrome, a perplexing disorder for which there is no very satisfactory remedy.

Pre-eclampsia
Pre-eclampsia is a major cause of maternal mortality. It is associated with increased intravascular coagulation and fibrin deposition. We have recently demonstrated that elevated plasma coagulation factor VII can help distinguish between women with Pre-eclampsia and women with a normal pregnancy.

Inflammation and cancer
Blood coagulation activation is an established complication of cancer. Despite advances in our understanding of the biology of cancer, the available diagnostic and prognostic tests for most of the common solid malignancies remain of limited value. One focus of active investigation in this area is the measurement of the procoagulant TF both as a potential marker and as a key to understanding some aspects of cancer biology.

Multidrug resistance
Multidrug resistance (MDR) is a potentially serious influence on cancer treatment and should feature in the design and application of therapeutic regimens. MDR cancer cell lines contain more Tissue Factor (TF) than parental cells which links to my other coagulopathy interests. The flipping of membrane phospholipid asymmetry is common to TF expression by monocytes, MDR in epithelial cancers and apoptosis. We have pursued this theme in experimental studies on co-expression of TF and P-Glycoprotein and the role of the nuclear envelope in drug resistance.

Infertility
Human semen spontaneously coagulates and then wholly liquefies in a way that bears similarity to blood coagulation and fibrinolysis. This process may play a major role in aiding sperm capacitation. However, the molecular basis for it remains poorly understood. Human semen is known to contain a large amount of TF associated with vesicular products of the prostate gland (prostasomes). Our work has resulted in the discovery of a number of key haemostatic factors in human semen. We have also studied the role of prostasomes, with their burden of bioactive membrane proteins in angiogenesis, using in vitro models to link with cancer progression and their role as vehicles for antioxidant delivery, important in dietary cancer chemoprevention.

Phd research

Past supervision includes 1 post-doctoral research fellow, 8 MD students, 2 MSc students, 1 MRes student, 10 medical students and 3 biomedical sciences graduate students.

Currently I supervise 1 PhD student and 1 Doctorate in Clinical Practice (DClinP) student.

Research group

Fundamental Care and Safety

Research project(s)

The role of bladder stretching in maintaining bladder health during long-term catheterisation

The potential use of medicinal honey in managing benign bladder pathologies

The effect of honey on parameters of wound healings: In vitro angiogenesis assays

Circulating haemostatic factors and pro-coagulant microparticles in pre-eclampsia

Cancer and drug resistance

I have managed the new BSc [Hons] in Healthcare Science programme for the two years of its existence, ensuring that space allocation, physical resources and logistic support were in place.
Recently I have become a Health Sciences representative on the University Senate.

I work closely with and hold memberships of several professional bodies, including representing the School at the Registration Council for Clinical Physiologists (incorporating the Professional Bodies Education Committee and Higher Education and Institution Modernising Scientific Careers) and the Council of Healthcare Science in higher education. I sit on a British Society for Haematology Science Sub-committee, influencing national strategy development and delivery. I also serve on the Thrombosis Committee of University Hospital Southampton NHS Foundation Trust (UHS).

I have performed editorial functions for the journals named elsewhere in this profile. I serve on the editorial reviewing board of a number of publishers and grant-awarding bodies.

Reaching out from the school, I also undertake voluntary translating work, facilitating doctor-patient communication within the hospital and represent the in-house Islamic community at the Multi-Faith Centre at UHS.

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Articles

Book Chapter

  • Lwaleed, B. A., & Kazmi, R. (1970). An overview of haemostasis. In M. Hall, A. Noble, & S. Smith (Eds.), A Foundation for Neonatal Care: A Multi-disciplinary Guide Oxford, UK: Radcliffe Publishing.

Conferences

Letters/Editorials

I am Programme and Admissions Leads for the BSc [Hons] in Healthcare Science course. I lead and teach on several modules and I am responsible for student placements outside of Health Sciences. I also teach on a number of other programmes internally and externally at both undergraduate and postgraduate levels.

Professor Bashir A Lwaleed
Health Sciences Student Office University of Southampton Highfield Southampton SO17 1BJ

Room Number: SGH/AA84/MP11

Facsimile: (023) 8120 6922

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