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Research project: The potential use of medicinal honey in managing benign bladder pathologies

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Interstitial cystitis/painful bladder syndrome (IC/PBS) is a distressing condition that affects many women. Mast cell accumulation and activation is a feature of (IC/PBS).

Current treatment options are suboptimal. A comparable situation pertains with long-term indwelling catheters, where biofilm build-up and infections are common. Our preliminary studies demonstrate that honey is well tolerated by in vitro organ culture models and that dilute honey inhibits mast cell degranulation. The aim of this on-going project is to lay the evidential and intellectual basis for moving towards clinical trials of topical honey as a treatment for (IC/PBS) and/or as a preventive against the sequelae of long term catheter usage by describing the distribution of mast cells in human bladders, measuring products of mast cell activation in urine and applying honey preparations to bladder-derived mast cell populations.

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