Phone:: (023) 8059 2438
Email:: P.S.Greulich@soton.ac.uk

Dr Philip Greulich

Lecturer

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Dr Philip Greulich is a Lecturer within Mathematical Sciences at the University of Southampton.

2016- : Lecturer, University of Southampton

2015-2016: Postdoctoral Associate, University of Cambridge, UK

2013-2014: Postdoctoral Fellow, University of Cambridge, UK

2010-2012: Postdoctoral Fellow, University of Edinburgh, UK

2010: PhD in Theoretical Physics, Saarland University, Germany

2006: Diploma in Physics, University of Cologne, Germany

Research

Publications

Teaching

PhD opportunities

Contact

Research interests

My research is in mathematical modelling of biological systems. My current focus is on stochastic modelling of cell dynamics and interactions in multi-cellular environments. To understand the cellular dynamics (e.g. proliferation,differentiation, and mobility), I follow principles of statistical physics, analysing the collective behaviour of cells and resulting emergent phenomena such as pattern formation, ordering, and phase transitions. My approach is data-driven; by comparison of mathematical models and experimental data through Bayesian methods, I infer the underlying biological principles of multicellular systems in diseases, such as cell proliferation/differentiation in cancer and bacterial growth under antibiotic influence.

Particular research interests (modelling):

Stochastic stem cell population dynamics
Bacterial population dynamics
Antibiotic pharmacodynamics
Evolution of drug resistances
Intracellular transport by motor proteins
Actin and microtubule dynamics
Protein synthesis; traffic of ribosomes

Research group

Applied Mathematics

Affiliate research group

Mathematics in Biology and Medicine

Research project(s)

Evolutionary Biology and Ecology

Mathematical Modelling

Molecular and Cellular Biology

Stochastic Processes in Biology

Articles

Frede, J., Greulich, P., Nagy, T., Simons, B. D., & Jones, P. H. (2016). A single dividing cell population with imbalanced fate drives oesophageal tumour growth. Nature Cell Biology, 18(9), 967-978. DOI: 10.1038/ncb3400

Greulich, P., & Simons, B. D. (2016). Dynamic heterogeneity as a strategy of stem cell self-renewal. Proceedings of National Academy of Sciences of the United States of America (PNAS), 113(27), 7509-7514. DOI: 10.17863/CAM.170, 10.1073/pnas.1602779113

Greulich, P., Scott, M., Evans, M. R., & Allen, R. J. (2015). Growth-dependent bacterial susceptibility to ribosome-targeting antibiotics. Molecular Systems Biology, 11(796), 1-11. DOI: 10.15252/msb.20145949

Alcolea, M. P., Greulich, P., Wabik, A., Frede, J., Simons, B. D., & Jones, P. H. (2014). Differentiation imbalance in single oesophageal progenitor cells causes clonal immortalization and field change. Nature Cell Biology, 16, 612-619. DOI: 10.1038/ncb2963

Greulich, P., Ciandrini, L., Romano, M. C., & Allen, R. J. (2012). Mixed population of competing totally asymmetric simple exclusion processes with a shared reservoir of particles. Physical Review E, 85(1), 011142-1 to 011142-11. DOI: 10.1103/PhysRevE.85.011142

Greulich, P., & Santen, L. (2011). Boundary-induced orientation of dynamic filament networks and vesicle agglomerations. Physical Review E: Statistical Physics, Plasmas, Fluids, and Related Interdisciplinary Topics, 84, 060902-1. [060902].

Greulich, P., & Santen, L. (2010). Active transport and cluster formation on 2D networks. European Physical Journal E, 32, 191-208.

Greulich, P., & Schadschneider, A. (2009). Disordered driven lattice gases with boundary reservoirs and Langmuir kinetics. Physical Review E, 79, 031107-1 - 031107-14. [031107]. DOI: 10.1103/PhysRevE.79.031107

Greulich, P., & Schadschneider, A. (2008). Phase diagram and edge effects in the ASEP with bottlenecks. Physica A: Statistical Mechanics and its Applications, 387(8-9), 1972-1986. DOI: 10.1016/j.physa.2007.11.037

Greulich, P., & Schadschneider, A. (2008). Single-bottleneck approximation for driven lattice gases with disorder and open boundary conditions. Journal of Statistical Mechanics: Theory and Experiment, N/A, N/A. [P04009].

Greulich, P., Basu, A., Garai, A., Chowdhury, D., Nishinari, K., & Tripathy, T. (2007). Intra-cellular traffic: bio-molecular motors on filamentary tracks. The European Physical Journal B: Condensed Matter and Complex Systems, 64, 593-600. DOI: 10.1140/epjb/e2008-00073-5

Greulich, P., Garai, A., Nishinari, K., Schadschneider, A., & Chowdhury, D. (2007). Intracellular transport by single-headed kinesin KIF!A: Effects of single-motor mechanochemistry and steric interactions. Physical Review E, 75, N/A. [041905]. DOI: 10.1103/PhysRevE.75.041905

Letter/Editorial

Greulich, P., Waclaw, B., & Allen, R. J. (2012). Mutational Pathway Determines Whether Drug Gradients Accelerate Evolution. Physical Review Letters, 109, 088101-1 to 088101-5.

Other University of Southampton sites

MATH1054 Academic Supervisor (Winter 2016/17)

Dr. Greulich is currently taking PhD students for projects in mathematical biology, related to cancer and stem cells (fully funded for 3 years).

Dr Philip Greulich
Building 54 Mathematical Sciences University of Southampton Highfield Southampton SO17 1BJ

Room Number:54/11003

Telephone:(023) 8059 2438
Email:P.S.Greulich@soton.ac.uk

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