The University of Southampton

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Phone:: (023) 8120 5081
Email:: S.Pender@soton.ac.uk

Dr Sylvia L.F. Pender BSc (Hons), PhD

Associate Professor in Mucosal Immunology,

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Dr Sylvia L.F. Pender is Associate Professor Reader in Mucosal Immunology, within Medicine at the University of Southampton.

The new way to make a difference

As a mucosal immunologist, her research based on how the mucosal immune and innate responses of the host can make the disease get better. She was one of the first to discover the involvement of matrix metalloproteinase in mucosal tissue inflammation in inflammatory bowel disease. Her current research shows new functions of MMPs and the related proteins which play important roles in anti-microbial infection, metabolic syndrome and aging disease such as osteoporosis.

Dr Pender has played a leading role in the protease field and is author of more than 50 journal articles on this topic. She is onthe editorial board of the World Journal of Gastroenterology and International Scholar Research Network – Inflammation. She is also an EU FP7 grant evaluator.

She is currently the Adjunct Associate Professor at International Medical University in Malaysia. She was a VC award winner in 2010 for promoting internationalization in the University. She is also a Global Partnership Award winner in 2013 for enhancing international research collaboration and partnership in Singapore, Malaysia and Hong Kong.

Qualifications

BSc.(Hons), Biochemical Sciences, University of Keele 1992
PhD, University of London 1996 (with an Overseas Research Scholarship award)

Appointments held

Research Fellow St Bartholomew’s and the Royal London School of Medicine and Dentistry, University of London. 1995

Non-clinical Lecturer, University of Southampton 2000

Senior Lecturer, University of Southampton 2005

Associate Professor (Reader) in Mucosal Immunology, University of Southampton 2009

Adjunct Associate Professor, International Medical University in Malaysia 2015 -2016

Research

Responsibilities

Publications

Teaching

Contact

Research interests

Sylvia’s research interest is based on the excessive production of matrix metalloproteinases (MMPs) contributes to the pathogenesis of many gut diseases as well as many diseases in other organs (i.e eye, heart, joint, lung, skin). The regulation of these enzymes can be governed by the inappropriate activation of the immune system. When myofibroblasts are stimulated with pro-inflammatory cytokines such as TNF-α and IL-1ß, MMP production is increased and mucosal ulceration ensues. Most importantly, the synthetic inhibitors of MMPs can inhibit the T cell-mediated tissue injury.

Current research extends the mechanistic studies of the immuno-regulatory response of tissue remodelling in a variety of disease states and organs, primarily those of the gut and the nose. Two EU FP7 funded collaborative research projects “IBDase” and "IPODD" were awarded to Sylvia’s research group in 2008. The two consortia involves twenty-one European research groups from different disciplines, including genetics, biochemistry, molecular biology, mucosal immunology, microbiology, and translational medicine, brought together to address the pathogenesis of inflammatory bowel diseases in patients and animal models with a focus on proteases and protease inhibitors.

Studies focus on the preclinical and clinical trials based on the results obtained from IBDase and IPODD. That includes:

Role of MMP-12 in the pathogenesis of IBD.
Stress induce relapse colitis
Antimicrobial activity of MMPs

Current research themes focus on:

Nutrition, metabolism, ageing and immunity in gut health
Anti-inflammatory effects of HDac inhibitor in IBD
Role of protease inhibitor in tissue restitution
Early detection of inflammation associated colorectal cancer
The role of bacteria in the formation of nasal polyps

Academic unit(s)

Clinical and Experimental Sciences Academic Units

Affiliate academic unit(s)

Infection and Immunity Research group

Postgraduate student supervision

MDs supervised to completion 2

PhDs supervised to completion 3

Current

Stephen Hayes (RCS ENT Surgical Research Fellow; PhD)

Serena Martelli (VC/A*STAR student; PhD)

Tim Biggs (ENT Surgical Research Fellow; PhD)

Ali Salamat (RCS ENT Surgical Research Fellow, PhD)

Faculty of Medicine

Associate Director International (2012-2014) – to assist the Associate Dean International & Enterprise in developing internationalization and global engagements

FINE group member to promote International research partnership

International Student Advisor to offer pastoral support to all international students in the Faculty

Member of Postgraduate Research Program Committee to oversee student matters related to international students

Home Office license holder

University of Southampton

University of Southampton Internationalization Forum (USIF), organizing committee member

WiSET Steering Committee member

VC's award winner in 2010 for promoting internationalization in the University of Southampton and

Global Partnership Award winner in 2013 to enhance international research collaborations.

National and International responsibilities

EU grant evaluator

Academic Editors-in-chief, Editorial Board, World Journal of Gastroenterology

Editor Board, International Scholar Research Network - Inflammation

Articles

Dryden, M., Cooke, J., Salib, R., Holding, R., Pender, S., & Brooks, J. (2017). Hot topics in reactive oxygen therapy: antimicrobial and immunological mechanisms, safety and clinical applications. Journal of Global Antimicrobial Resistance.

Chen, S-Y., Huang, M-T., Pender, S. L. F., Ruslin, M., Chou, H-H., & Ou, K-L. (2017). The application of silver nano-particles on developing potential treatment for chronic rhinosinusitis: Antibacterial action and cytotoxicity effect on human nasal epithelial cell model. Materials Science and Engineering C. DOI: 10.1016/j.msec.2017.03.189

Kared, H., Martelli, S., Ng, T. P., Pender, S. L. F., & Larbi, A. (2016). CD57 in human natural killer cells and T-lymphocytes. Cancer Immunology Immunotherapy, 1-12. DOI: 10.1007/s00262-016-1803-z

Dryden, M., Cooke, J., Salib, R., Holding, R., Pender, S., & Brooks, J. (2016). Hot hopics in Reactive Oxygen therapy: antimicrobial and 2 immunological mechanisms, safety, and clinical applications. Journal of Global Antimicrobial Resistance, 1-9.

Biancheri, P., Di Sabatino, A., Rescigno, M., Giuffrida, P., Fornasa, G., Tsilingiri, K., ... Corazza, G. (2015). Abnormal thymic stromal lymphopoietin expression in the duodenal mucosa of patients with coeliac disease. Gut. DOI: 10.1136/gutjnl-2014-308876

Martelli, S., Pender, S. L., & Larbi, A. (2015). Compartmentalization of immunosenescence: a deeper look at the mucosa. Biogerontology, 1-18. DOI: 10.1007/s10522-015-9628-2

Hayes, S. M., Howlin, R., Johnston, D. A., Webb, J. S., Clarke, S. C., Stoodley, P., ... Salib, R. J. (2015). Intracellular residency of Staphylococcus aureus within mast cells in nasal polyps: A novel observation. Journal of Allergy and Clinical Immunology, 135(6), 1648-1651. DOI: 10.1016/j.jaci.2014.12.1929

Jurk, D., Wilson, C., Passos, J. F., Oakley, F., Correia-Melo, C., Greaves, L., ... von Zglinicki, T. (2014). Chronic inflammation induces telomere dysfunction and accelerates ageing in mice. Nature Communications, 2(4172). DOI: 10.1038/ncomms5172

Cleynen, I., Vazeille, E., Artieda, M., Verspaget, H. W., Szczypiorska, M., Bringer, M. A., ... Darfeuille-Michaud, A. (2014). Genetic and microbial factors modulating the ubiquitin proteasome system in inflammatory bowel disease. Gut, 63(8), 1265-1274. DOI: 10.1136/gutjnl-2012-303205

Biancheri, P., Pender, S. L. F., Ammoscato, F., Giuffrida, P., Sampietro, G., Ardizzone, S., ... Di Sabatino, A. (2013). The role of interleukin 17 in Crohn's disease-associated intestinal fibrosis. Fibrogenesis & Tissue Repair, 6. DOI: 10.1186/1755-1536-6-13

Motterle, A., Xiao, Q., Kiechl, S., Pender, S. L. F., Morris, G. E., Willeit, J., ... Ye, S. (2012). Influence of matrix metalloproteinase- 12 on fibrinogen level. Atherosclerosis, 220(2), 351-354. DOI: 10.1016/j.atherosclerosis.2011.11.003

Edwards, A. J. P., & Pender, S. L. F. (2011). Histone deacetylase inhibitors and their potential role in inflammatory bowel diseases. Biochemical Society Transactions, 39(4), 1092-1095.

Vazeille, E., Bringer, M-A., Gardarin, A., Chambon, C., Becker-Pauly, C., Pender, S. L. F., ... Darfeuille-Michaud, A. (2011). Role of meprins to protect ileal mucosa of Crohn's disease patients from colonization by adherent-invasive E. coli. PLoS ONE, 6(6), e21199. DOI: 10.1371/journal.pone.0021199

Di Sabatino, A., Battista, N., Biancheri, P., Rapino, C., Rovedatti, L., Astarita, G., ... Corazza, G. R. (2011). The endogenous cannabinoid system in the gut of patients with inflammatory bowel disease. Mucosal Immunology, 4(5), 574-583. DOI: 10.1038/mi.2011.18

Gordon, J. N., Prothero, J. D., Thornton, C. A., Pickard, K. M., Di Sabatino, A., Goggin, P. M., ... Macdonald, T. T. (2009). CC-10004 but not thalidomide or lenalidomide inhibits lamina propria mononuclear cell TNF-alpha and MMP-3 pr with inflammatory bowel disease. Journal of Crohn's and Colitis, 3(3), 175-182. DOI: 10.1016/j.crohns.2009.03.001

Di Sabatino, A., Saarialho-Kere, U., Buckley, M. G., Gordon, J. N., Biancheri, P., Rovedatti, L., ... Pender, S. L. F. (2009). Stromelysin-1 and macrophage metalloelastase expression in the intestinal mucosa of Crohn’s disease patients treated with infliximab. European Journal of Gastroenterology & Hepatology, 21(9), 1049-1055. DOI: 10.1097/MEG.0b013e3283293d0f

Di Sabatino, A., Jackson, C. L., Pickard, K. M., Buckley, M., Rovedatti, L., Leakey, N. A., ... Pender, S. L. F. (2009). Transforming growth factor beta signalling and matrix metalloproteinases in the mucosa overlying Crohn's disease strictures. Gut, 58(6), 777-789. DOI: 10.1136/gut.2008.149096

Pender, S. L. F. (2008). Do metalloproteinases contribute to tissue destruction or remodeling in the inflamed gut? Inflammatory Bowel Diseases, 14(S2), S136-S137. DOI: 10.1002/ibd.20630

Gordon, J. N., Pickard, K. M., Di Sabatino, A., Prothero, J. D., Pender, S. L. F., Goggin, P. M., & MacDonald, T. T. (2008). Matrix metalloproteinase-3 production by gut IgG plasma cells in chronic inflammatory bowel disease. Inflammatory Bowel Disease, 14(2), 195-203. DOI: 10.1002/ibd.20302

Di Sabatino, A. D., Pender, S. L. F., Jackson, C. L., Prothero, J. D., Gordon, J. N., Picariello, L., ... MacDonald, T. T. (2007). Functional modulation of Crohn's disease myofibroblasts by anti-tumor necrosis factor antibodies. Gastroenterology, 133(1), 137-149. DOI: 10.1053/j.gastro.2007.04.069

Kruidenier, L., MacDonald, T. T., Collins, J. E., Pender, S. L., & Sanderson, I. R. (2006). Myofibroblast matrix metalloproteinases activate the neutrophil chemoattractant CXCL7 from intestinal epithelial cells. Gastroenterology, 130(1), 127-136. DOI: 10.1053/j.gastro.2005.09.032

Pender, S. L. F., Li, C. K. F., Di Sabatino, A., MacDonald, T. T., & Buckley, M. G. (2006). Role of macrophage metalloelastase in gut inflammation. [Issue: Inflammatory Bowel Disease: Genetics, Barrier Function, Immunologic Mechanisms and Microbial]. Annals of the New York Academy of Sciences, 1072, 386-388. DOI: 10.1196/annals.1326.019

Pender, S. L-F., Chance, V., Whiting, C. V., Buckley, M., Edwards, M., Pettipher, R., & MacDonald, T. T. (2005). Systemic administration of the chemokine macrophage inflammatory protein 1? exacerbates inflammatory bowel disease in a mouse model. Gut, 54(8), 1114-1120. DOI: 10.1136/gut.2004.052779

Salmela, M. T., Pender, S. L. F., Karjalainen-Lindsberg, M. L., Puolakkainen, P., MacDonald, T. T., & Saarialho-Kere, U. (2004). Collagenase-1 (MMP-1), matrilysin-1 (MMP-7), and stromelysin-2 (MMP-10) are expressed by migrating enterocytes during intestinal wound healing. Scandinavian Journal of Gastroenterology, 39(11), 1095-1104. DOI: 10.1080/00365520410003470

Li, C. K. F., Pender, S. L. F., Pickard, K. M., Chance, V., Holloway, J. A., Huett, A., ... MacDonald, T. T. (2004). Impaired immunity to intestinal bacterial infection in stromelysin-1 (matrix metalloproteinase-3)-deficient mice. Journal of Immunology, 173(8), 5171-5179.

Pender, S. L. F., & MacDonald, T. T. (2004). Matrix metalloproteinases and the gut - new roles for old enzymes. Current Opinion in Pharmacology, 4(6), 546-550. DOI: 10.1016/j.coph.2004.06.005

Pender, S. L. F., Croucher, P. J., Mascheretti, S., Prothero, J. D., Fisher, S. A., MacDonald, T. T., ... Ye, S. (2004). Transmission disequilibrium test of stromelysin-1 gene variation in relation to Crohn's disease. Journal of Medical Genetics, 41(9), e112. DOI: 10.1136/jmg.2004.023572

Mimura, T., Bateman, A. C., Lee, R. L., Johnson, P. A., McDonald, P. J., Talbot, I. C., ... Pender, S. L. F. (2004). Up-regulation of collagen and tissue inhibitors of matrix metalloproteinase in colonic diverticular disease. Diseases of the Colon & Rectum, 47(3), 371-378. DOI: 10.1007/s10350-003-0050-5

Monteleone, G., Holloway, J., Salvati, V. M., Pender, S. L-F., Fairclough, P. D., Croft, N., & MacDonald, T. T. (2003). Activated STAT4 and a functional role for IL-12 in human Peyer's patches. Journal of Immunology, 170(1), 300-307.

Pender, S. L. F., Braegger, C., Günther, U., Monteleone, G., Meuli, M., Schuppan, D., & MacDonald, T. T. (2003). Matrix metalloproteinases in necrotising enterocolitis. Pediatric Research, 54(2), 160-164. DOI: 10.1203/01.PDR.0000072326.23442.C3

Shek, F. W-T., Benyon, R. C., Walker, F. M., McCrudden, P. R., Pender, S. L. F., Williams, E. J., ... Iredale, J. P. (2002). Expression of transforming growth factor-?1 by pancreatic stellate cells and its implications for matrix secretion and turnover in chronic pancreatitis. The American Journal of Pathology, 160(5), 1787-1798. DOI: 10.1016/S0002-9440(10)61125-X

Shek, F. W-T., Benyon, R. C., Walker, F. M., McCrudden, P. R., Pender, S. L. F., Williams, E. J., ... Iredale, J. P. (2002). Expression of transforming growth factor-ß1 by pancreatic stellate cells and its implications for matrix secretion and turnover in chronic pancreatitis. The American Journal of Pathology, 160(5), 1787-1798.

Salmela, M. T., MacDonald, T. T., Black, D., Irvine, B., Zhuma, T., Saarialho-Kere, U., & Pender, S. L. F. (2002). Upregulation of matrix metalloproteinases in a model of T cell mediated tissue injury in the gut: analysis by gene array and in situ hybridisation. Gut, 51(4), 540-547.

Jones, C. A., Vance, G. H., Power, L. L., Pender, S. L. F., MacDonald, T. T., & Warner, J. O. (2001). Costimulatory molecules in the developing human gastrointestinal tract: a pathway for fetal allergen priming. Journal of Allergy and Clinical Immunology, 108(2), 235-241. DOI: 10.1067/mai.2001.117178

Monteleone, G., Pender, S. L. F., Wathen, N. C., & MacDonald, T. T. (2001). Interferon-alpha drives T cell-mediated immunopathology in the intestine. European Journal of Immunology, 31(8), 2247-2255. DOI: 10.1002/1521-4141(200108)31:8<2247::AID-IMMU2247>3.0.CO;2-4

Shaida, A., Kenyon, G., Devalia, J., Davies, R. J., MacDonald, T. T., & Pender, S. L. F. (2001). Matrix metalloproteinases and their inhibitors in the nasal mucosa of patients with perennial allergic rhinitis. Journal of Allergy and Clinical Immunology, 108(5), 791-796. DOI: 10.1067/mai.2001.119024

Salmela, M. T., Pender, S. L. F., Reunala, T., MacDonald, T., & Saarialho-Kere, U. (2001). Parallel expression of macrophage metalloelastase (MMP-12) in duodenal and skin lesions of patients with dermatitis herpetiformis. Gut, 48(4), 496-502.

Monteleone, G., Pender, S. L. F., Alstead, E., Hauer, A. C., Lionetti, P., & MacDonald, T. T. (2001). Role of interferon ? in promoting T helper cell type 1 responses in the small intestine in coeliac disease. Gut, 48(3), 425-429.

Pender, S. L. F., Quinn, J. J., Sanderson, I. R., & MacDonald, T. T. (2000). Butyrate upregulates stromelysin-1 production by intestinal mesenchymal cells. American Journal of Physiology. Gastrointestinal and Liver Physiology, 279(5), G918-G924.

Nagata, S., McKenzie, C., Pender, S. L. F., Bajaj-Elliott, M., Fairclough, P. D., Walker-Smith, J. A., ... MacDonald, T. T. (2000). Human Peyer's patch T cells are sensitized to dietary antigen and display a Th cell type 1 cytokine profile. Journal of Immunology, 165(9), 5315-5321.

Heuschkel, R. B., MacDonald, T. T., Monteleone, G., Bajaj-Elliott, M., Smith, J. A., & Pender, S. L. (2000). Imbalance of stromelysin-1 and TIMP-1 in the mucosal lesions of children with inflammatory bowel disease. Gut: an International Journal of Gastroenterology and Hepatology, 47(1), 57-62. DOI: 10.1136/gut.47.1.57

Pender, S. L., Salmela, M. T., Monteleone, G., Schnapp, D., McKenzie, C., Spencer, J., ... MacDonald, T. T. (2000). Ligation of alpha4ss1 integrin on human intestinal mucosal mesenchymal cells selectively Up-regulates membrane type-1 matrix metalloproteinase and confers a migratory phenotype. The American Journal of Pathology, 157(6), 1955-1962.

MacDonald, T. T., Monteleone, G., & Pender, S. L. (2000). Recent developments in the immunology of inflammatory bowel disease. Scandinavian Journal of Immunology, 51(1), 2-9. DOI: 10.1046/j.1365-3083.2000.00658.x

Monteleone, G., MacDonald, T. T., Wathen, N. C., Pallone, F., & Pender, S. L. F. (1999). Enhancing lamina propria Th1 cell responses with interleukin 12 produces severe tissue injury. Gastroenterology, 117(5), 1069-1077. DOI: 10.1016/S0016-5085(99)70391-4

Pender, S. L., McKenzie, C., Shaida, A., & MacDonald, T. T. (1999). Regulation of matrix metalloproteinases in human intestinal mucosa. Annals of the New York Academy of Sciences, 878, 581-582. DOI: 10.1111/j.1749-6632.1999.tb07733.x

MacDonald, T. T., Bajaj-Elliott, M., & Pender, S. L. F. (1999). T cells orchestrate intestinal mucosal shape and integrity. Immunology Today, 20(11), 505-510. DOI: 10.1016/S0167-5699(99)01536-4

Pender, S. L., Fell, J. M., Chamow, S. M., Ashkenazi, A., & MacDonald, T. T. (1998). A p55 TNF receptor immunoadhesin prevents T cell-mediated intestinal injury by inhibiting matrix metalloproteinase production. Journal of Immunology, 160(8), 4098-4103.

Bajaj-Elliott, M., Poulsom, R., Pender, S. L., Wathen, N. C., & MacDonald, T. T. (1998). Interactions between stromal cell--derived keratinocyte growth factor and epithelial transforming growth factor in immune-mediated crypt cell hyperplasia. Journal of Clinical Investigation, 102(8), 1473-1480. DOI: 10.1172/JCI2792.

MacDonald, T. T., & Pender, S. L. F. (1998). Proteolytic enzymes in inflammatory bowel disease. Inflammatory Bowel Diseases, 4(2), 157-164. DOI: 10.1002/ibd.3780040211

Pender, S. L., & MacDonald, T. T. (1998). Regulation of matrix metalloproteinase production in human fetal intestinal mesenchymal cells by cytokines and the bacterial superantigen Staphylococcus aureus enterotoxin B. Annals of the New York Academy of Sciences, (859), 188-191.

Pender, S. L., Breese, E. J., Gunther, U., Howie, D., Wathen, N. C., Schuppan, D., & MacDonald, T. T. (1998). Suppression of T cell-mediated injury in human gut by interleukin 10: role of matrix metalloproteinases. Gastroenterology, 115(3), 573-583. DOI: 10.1016/S0016-5085(98)70136-2

Bajaj-Elliott, M., Pender, S. L., Poulsom, R., & Macdonald, T. T. (1998). Upregulation of keratinocyte growth factor during T-cell immunity in the gut mucosa. Annals of the New York Academy of Sciences, (859), 184-187.

Pender, S. L., Tickle, S. P., Docherty, A. J., Howie, D., Wathen, N. C., & MacDonald, T. T. (1997). A major role for matrix metalloproteinases in T cell injury in the gut. Journal of Immunology, 158(4), 1582-1590.

Pender, S. L., Lionetti P, P., Murch, S. H., Wathan, N., & MacDonald, T. T. (1996). Proteolytic degradation of intestinal mucosal extracellular matrix after lamina propria T cell activation. Gut: an International Journal of Gastroenterology and Hepatology, 39(2), 284-290. DOI: 10.1136/gut.39.2.284

Thomas, R., Schurmann, G., Lionetti, P., Pender, S. L. F., & MacDonald, T. T. (1996). T cell receptor V beta expression in human intestine: regional variation in postnatal intestine and biased usage in fetal gut. Gut: an International Journal of Gastroenterology and Hepatology, 38(2), 190-195. DOI: 10.1136/gut.38.2.190

Book Chapters

MacDonald, T. T., & Pender, S. L. F. (2004). Mechanisms of tissue injury. In R. B. Sartor, & W. J. Sandborn (Eds.), Inflammatory Bowel Diseases. Sixth Edition. (pp. 163-178). United States, US: Saunders.

Pender, S. L. F. (1998). Lamina propria T cells. In T. T. MacDonald (Ed.), Chemical Immunology: Mucosal T cells. (pp. 103-117). (Chemical Immunology and Allergy; Vol. 71). Basel, CH: Karger. DOI: 10.1159/000058721

Lionetti, P., Pender, S. L. F., & MacDonald, T. T. (1995). Relationship between the extent of mucosal T cell and macrophage activation and mucosal damage. In S. Auricchio, & A. Ferguson (Eds.), Mucosal Immunity and the Gut Epithelium: Interactions in Health and Disease. (pp. 84-89). (Dynamic Nutrition Research; Vol. 4). Karger.

BM4 and BM5. Deliver lectures in Inflammatory Bowel Disease symposium, introduces basic immunological aspects of gut inflammation.

BM4 Graduate group facilitator.

All International students.

Provides pastoral support in the Faculty, organizes social gatherings and buddy system for all PGR, PTG and UG students in role of International Student Advisor.

Received a VC’s award in 2010 for promoting internationalization in the University of Southampton.

Dr Sylvia L.F. Pender
Faculty of Medicine, University of Southampton, Building 85, Life Sciences Building, Highfield Campus, Southampton, SO171BJ

Room Number:SGH//MP813

Telephone:(023) 8120 5081
Email:S.Pender@soton.ac.uk

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