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The University of Southampton
Medicine

Research project: BREATHE4T (Breathing REtraining for Asthma Trial of Home Exercises for Teenagers)

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A multi-disciplinary programme of work funded by the NIHR RfPB (National Institute of Health Research, Research for Patient Benefit), started in August 2019. We will repurpose and optimise the adult BREATHE breathing retraining intervention for young people (aged 12-17 years) with asthma and then assess its acceptability as preparatory work for a Phase III definitive study.

The study will last 2 years with 3 phases as described below:

Objectives:

  • Phase 1 (months 1-6) - Intervention planning:

Behavioural analysis to identify key, adolescent specific, behavioural issues, needs and challenges that the intervention must address, drawing on literature, qualitative interviews and consultation with study Patient and Public Involvement (PPI) panels.

  • Stage 2 (months 6-12) – Intervention development:

To develop and optimise the breathing retraining intervention, using feedback from iterative qualitative research with young people with asthma and active involvement of PPI panels.

  • Stage 3: (months 12-24):

Trialling of breathing retraining intervention in real-life context to evaluate acceptability and feasibility in practice. A total of 116 young people with asthma will be randomised to the intervention or control and reassessed after 6 months. Key objectives: assess acceptability, uptake, success in collecting follow up data and variance in asthma-related outcome measures.

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