Professor Stephen Holgate CBE, BSc, MB BS, MD, DSc, FRCP, FRCP (Edin), FRCPath, FIBMS, FSB, CSc (Hon), FMedSci
Medical Research Council Clinical Professor of Immunopharmacology and Honorary Consultant Physician, Honorary Visiting Research Professorship, University of Melbourne, Australia,Honorary Visiting Professorship in Translational Medicine, University of Manchester

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Professor Stephen Holgate is Medical Research Council Clinical Professor of Immunopharmacology and Honorary Consultant Physician within Medicine at the University of Southampton.
Stephen Holgate is Medical Research Council Clinical Professor of Immunopharmacology at the Faculty of Medicine, Southampton, UK. After completing his medical training in London he spent 2 years at Harvard Medical School to acquire skills in allergic disease mechanisms. On returning to Southampton in 1980, he set up a research group focused on the mechanisms of asthma. He has utilized many approaches to study this disease including epidemiology, genetics, pathology, microbiology and immunology, pharmacology and experimental medicine. This research has informed guidelines on asthma management and has identified and validated novel therapeutic targets. Notable research contributions include the role of mast cells and their mediators in asthma and allied disorders, the regulation and pharmacology of mast cells, placing inflammation at the core of asthma pathophysiology, uncovering the role of respiratory viruses, allergens and pollutants in asthma exacerbation, the discovery of defects in innate immune responses in asthmatic airways, mechanisms of airway wall remodelling and the discovery of novel asthma susceptibility genes such as ADAM33.
His current research focuses on stratified medicine, the role of the epithelium in orchestrating asthma and the evolution of asthma across the lifecourse. His work has resulted in over 980 peer reviewed publications (H index 133), 60 Book editorships, 453 Book Chapters and Reviews, 48 Editorials, 76 Official and Government Reports. He holds an MRC programme grant focused on the pathogenesis of asthma.
He is a Past President of the British Society of Allergy and Clinical Immunology and British Thoracic Society, was Chair of the MRC Population and Systems Medicine Board (PSMB). Stephen is Chair of Main Panel A (Medicine, Health and Life Sciences) of the UK Research Excellence Framework 2014, Chairs the UK National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs), the British Lung Foundation Research Committee, the Hazardous Substances Advisory Committee (HSAC), and from 2014, will join the Science and Innovation Strategy Board of the Natural Environment Research Council (NERC). He is Chair of the European Respiratory Society Scientific Committee, Treasurer of the World Allergy Organization and Member of the Medical Science Committee of Science Europe. In 2003 he cofounded of Synairgen a publically quoted respiratory drug development company with a particular focus on lung antiviral defense in asthma, COPD and severe viral infections.
Qualifications
BSc Biochemistry (Class I), London University (1968)
MB BS, Medicine/Surgery, London University (Charing Cross Hospital Medical School) (1971)
MD, Asthma Research, London University (1979)
DSc, Inflammatory Basis of Asthma, University of Southampton (1991)
MRCP (UK), Royal College of Physicians (1973)
FRCP, Royal College of Physicians of London (1984)
FRCP (Edin), Royal College of Physicians of Edinburgh (1995)
FMedSci, Foundation Fellow, Academy of Medical Sciences (1997)
FSB, Biological Society, (1999)
FRCPath, Royal College of Pathologists, (1999)
FIBMS, Institute of Biomedical Science, (2009)
CSci (Hon), Science Council, (2009)
Postgraduate Fellowships
MRCP (UK), Royal College of Physicians (1973)
FRCP, Royal College of Physicians of London (1984)
FRCP (Edin), Royal College of Physicians of Edinburgh (1995)
FMedSci, Foundation Fellow, Academy of Medical Sciences (1997)
FSB, Biological Society, (1999)
FRCPath, Royal College of Pathologists, (1999)
FBMS, Institute of Biomedical Science, (2009)
CSci (Hon), Science Council, (2009)
Honours and Distinctions
1978 Medical Research Council Dorothy Temple Cross & Wellcome Trust Travel Fellowship
1990 Philip Ellman Lecturer, Royal College of Physicians
President, British Society of Allergy and Clinical Immunology (BSACI) (to 1993)
1991 Hurst Brown Visiting Professorship, University of Toronto, Canada
Altounyan Lecture, British Thoracic Society
1992 Cournand Lecture, European Respiratory Society
1993 James-Parkinson Memorial Lecture, Society of Occupational Medicine
Thomas Young Medal, St George's Hospital, London
Royal College of Physicians Graham Bull Prize for Clinical Research
1994 Lilly Lecture, Royal College of Physicians of Edinburgh
CIBA Foundation Lecture, Science Festival, Edinburgh
Jack Pepys Lecture, British Society for Allergy and Clinical Immunology
Scientific Achievement Award, International Association of Allergy and Clinical Immunology,
Stockholm
1995 Robert Cooke Memorial Lecture, American Academy of Allergy and Immunology
Visiting Professor, Ontario Thoracic Society, Canada
Rhône-Poulenc Rorer World Health Award ($20,000)
1996 Honorary Fellow, South African Pulmonology Society
Priscilla Piper Memorial Lecturer, Royal College of Surgeons
Honorary Member, Nordic Society of Allergology
Evening Discourse, Royal Institution of Great Britain
Visiting Professor, Vanderbilt University, USA
1997 Visiting Professor, Harvard University, Boston, USA
1998 Visiting Professor, University of Rochester USA
Brian Sproule Lecture, University of Alberta, Canada
1999 King Faisal International Prize in Medicine (Gold Medal, $200,000)
Medal for Scientific Achievement, Rijksuniversity, Gent, Belgium
Ranked No.8 in UK Citations in Biomolecular Subjects (ISI), 1990-2000
2000 Lumleian Lecture, Royal College of Physicians
Robert Cooke Memorial Lecture, American Academy of Allergy, Asthma and Immunology
Honorary Member, Germany Society for Pulmonology
Alec Sehon Distinguished Professorship in Allergy, University of Manitoba, Canada
2001 Visiting Professor, Yale University School of Medicine
The Honorary Fellow Award, American Academy of Allergy, Asthma & Immunology
Visiting Professor, Harvard Medical School, Boston, USA
Czech Republic Medical Society Medal for Scientific Achievement, Prague
Overseas Fellow, Polish Academy of Science
ISI Most Highly Cited Researcher for Publications 1980-2011
Visiting Professor, Thomas Jefferson Medical College, Philadelphia, USA
2002 Visiting Professor, University of Cincinnati Medical Center, USA
Norman Sterrie Lecture, University of Minnesota, USA
Highly Cited Researcher (Original Member, Highly Cited Researchers database, ISI)
2003 Sir William Osler Lecture, Association of Physicians of GB and Ireland
Ellison-Cliffe Medal, Royal Society of Medicine
GB West Memorial Lecture, European Histamine Research Society
Scientific Achievement Award, International Association of Asthmology (Interasma)
2004 Visiting Professor, University of Michigan, Ann Arbor, USA
Visiting Professor, Wake Forest University, Winston-Salem, N Carolina, USA
Health and Life Sciences Gold Medal, Rijksuniversity, Gent, Belgium
Honorary Member, Association of Physicians of Great Britain and Ireland
Honorary Fellow, American College of Asthma, Allergy and Immunology (ACAAI)
Honorary Member, Biochemical Society
British Pharmacological Society Quintiles Prize in Immunopharmacology
Hospital Doctor Academic Medicine Team of the Year Award
2005 Overseas Member, American Association of Physicians (AAP)
Visiting Professor, University of British Columbia, Canada
Visiting Professor, UCSF and the Sandler Asthma Foundation, USA
Sir Anthony Dawson lecture, Royal London and St Bartholomew’s Hospitals
2006 The Huxley Lecture, Imperial College, London
Burns Lecture, RCP Glasgow
Honorary Member, DGAKI (German Society of Allergy and Clinical Immunology)
President of the British Thoracic Society
2007 Visiting Professor, John Hopkins Bloomberg School of Public Health, Baltimore, USA
Visiting Professor Harvard Medical School, Boston and Ohio State, University, Ohio, USA
BMA Medical Book of the Year Award for Allergy 3rd edition
Royal Society of Medicine Book Commendation for Allergy 3rd edition
2008 Paul Ehrlich Award for Research, European Academy of Allergy, Asthma and Clinical
Immunology
Honorary Visiting Professorship, University of Manchester (renewed 2012)
2009 Opening Plenary Lecture, Keystone Conference on Asthma and Allergy
Honorary Fellowship of the Institute of Biomedical Science
Council of the Academy of Medical Sciences
Honorary Chartered Scientist (CSci), Science Council
Almroth Wright Lecture, Imperial College
2010 David W Talmage Lectureship, Aspen Allergy Jack Selner Conference, Colorado, USA
Jeffrey Drazen Visiting Professor, Harvard Medical School, US
2011 Commander of the Order of the British Empire (Queen’s New Year Honours List)
Honorary Life Membership of the Primary Care Respiratory Society UK
2nd Most cited European author 1998-2009 in Respiratory Research
Senior Investigator, National Institute for Health Research (NIHR)
2012 Miegunyah Distinguished Visiting Fellowship, University of Melbourne
American Thoracic Society (ATS) Recognition Award for Scientific Accomplishments (first time award was made outside N America)
Alain De Weck Honorary Lecture, VI World Asthma and COPD Forum, NY, USA
2013 Honorary Visiting Research Professorship, University of Melbourne, Australia
Longdagen Lecture 2013, Longdagen Scientific Conference, Utrecht, Netherlands
The Annual Wade Lecture, Faculty of Medicine University of Southampton
2014 The K Frank Austen Visiting Professor, Harvard University, USA
Keynote lecture, Keystone Conference on Biologics
Appointments held
House Physician, Charing Cross Hospital, London, 1971-2
Senior House Officer (Neurology), National Hospital for Nervous Diseases,
London, 1972-3
Senior House Officer (Respiratory Medicine & Cardiology), Brompton Hospital, London, 1973-4
Registrar (General Medicine), General Infirmary, Salisbury & Southampton General Hospital, 1974-5
Lecturer and Honorary Senior Registrar in Medicine, Southampton General and Western Hospitals, 1975-80
MRC and Wellcome Trust Overseas Research Fellow, Harvard University, Boston, USA, 1978-80
Lecturer in Medicine and Honorary Senior Registrar, University of Southampton Hospitals, 1975-80
Senior Lecturer, Reader then Professor of Medicine and Hon Consultant Physician, Southampton University Hospitals, 1980-6
MRC Clinical Professor of Medicine and Honorary Consultant Physician, Southampton University and Foundation Trust, 1987-present