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Research project

Ageing Lungs in European Cohorts (ALEC Study)

Project overview

This project aims to improve our understanding of the determinants and risk factors for low lung function, respiratory disability and the development of chronic obstructive lung disease (COPD), through exploitation of information held within existing cohorts and their population–based biobanks. Even though COPD has long been viewed as a predominantly smoking-related disease, more than 30% of people with COPD have never smoked, and there is increasing awareness that other risk profiles must contribute to disease. COPD is a major cause of disease, disability and death in European adults and lung function is a critical objective marker of good lung health, strongly associated with other major chronic diseases (for example, cardiovascular disease) and is a major independent determinant of overall health status (physical and mental health, quality of life, exercise capacity, independent living).

Staff

Lead researcher

Professor John Holloway PhD, FHEA

Associate V-P Interdisciplinary Research

Research interests

  • Human genetics
  • Epigenetics
  • Respiratory Disease

Research outputs

Residential greenness-related DNA methylation changes
Ayoung Jeong,
Ikenna C. Eze,
Danielle Vienneau,
Kees De Hoogh,
Dirk Keidel,
Thomas Rothe,
Luc Burdet,
John W. Holloway,
Debbie Jarvis,
Florian Kronenberg,
Gianfranco Lovison,
Medea Imboden,
& Nicole Probst-hensch
, 2022 , Environment International , 158 , 106945
DOI: 10.1016/j.envint.2021.106945
Type: article
Causal effects of body mass index on airflow obstruction and forced mid-expiratory flow: a Mendelian randomization study taking interactions and age-specific instruments Into consideration toward a life course perspective
Nicole Probst-Hensch,
Ayoung Jeong,
Daiana Stolz,
Marco Pons,
Paola M Soccal,
Robert Bettschart,
Deborah Jarvis,
John W Holloway,
Florian Kronenberg,
Medea Imboden,
Christian Schindler,
& Gianfranco F Lovison
, 2021 , Frontiers in Public Health , 9 , 584955
DOI: 10.3389/fpubh.2021.584955
Type: article
Epigenome-wide association study of lung function level and its change
Medea Imboden,
Matthias Wielscher,
Faisal I. Rezwan,
André F.S. Amaral,
Emmanuel Schaffner,
Ayoung Jeong,
Anna Beckmeyer-Borowko,
Sarah E. Harris,
John M. Starr,
Ian J. Deary,
Claudia Flexeder,
Melanie Waldenberger,
Annette Peters,
Holger Schulz,
Su Chen,
Shadia Khan Sunny,
Wilfried J.J. Karmaus,
Yu Jiang,
Gertraud Erhart,
Florian Kronenberg,
Ryan Arathimos,
Gemma C. Sharp,
Alexander John Henderson,
Yu Fu,
Paivi Piirila,
Kirsi H. Pietiläinen,
Miina Ollikainen,
Åsa Johansson,
Ulf Gyllensten,
Maaike de Vries,
Diana A. van der Plaat,
Kim de Jong,
H. Marike Boezen,
Ian P. Hall,
Martin D. Tobin,
Marjo-Riitta Jarvelin,
John Holloway,
Deborah Jarvis,
& Nicole M. Probst-Hensch
, 2019 , European Respiratory Journal , 54 (1)
DOI: 10.1183/13993003.00457-2019
Type: article
Association of height growth in puberty with lung function
Osama Mahmoud,
Raquel Granell,
Kate Tilling,
Cosetta Minelli,
Judith Garcia-Aymerich,
John W. Holloway,
Adnan Custovic,
Deborah Jarvis,
Jonathan Sterne,
& John Henderson
, 2018 , American Journal of Respiratory and Critical Care Medicine , 198 (12) , 1539--1548
DOI: 10.1164/rccm.201802-0274OC
Type: article
SERPINA1 methylation and lung function in tobacco-smoke exposed European children and adults
Anna Beckmeyer-Borowko,
Medea Imboden,
Faisal I. Rezwan,
Matthias Wielscher,
Andre F.S. Amaral,
Ayoung Jeong,
Emmanuel Schaffner,
Juha Auvinen,
Sylvain Sebert,
Ville Karhunen,
Robert Bettschart,
Alexander Turk,
Marco Pons,
Daiana Stolz,
Florian Kronenberg,
Ryan Arathimos,
Gemma C. Sharp,
Caroline Relton,
Alexander J. Henderson,
Marjo-Riitta Jarvelin,
Deborah Jarvis,
John W. Holloway,
& Nicole M. Probst-Hensch
, 2018 , Respiratory Research , 19 (1) , 1--14
DOI: 10.1186/s12931-018-0850-8
Type: article
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