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Research project

Ageing Lungs in European Cohorts (ALEC Study)

Project overview

This project aims to improve our understanding of the determinants and risk factors for low lung function, respiratory disability and the development of chronic obstructive lung disease (COPD), through exploitation of information held within existing cohorts and their population–based biobanks. Even though COPD has long been viewed as a predominantly smoking-related disease, more than 30% of people with COPD have never smoked, and there is increasing awareness that other risk profiles must contribute to disease. COPD is a major cause of disease, disability and death in European adults and lung function is a critical objective marker of good lung health, strongly associated with other major chronic diseases (for example, cardiovascular disease) and is a major independent determinant of overall health status (physical and mental health, quality of life, exercise capacity, independent living).


Lead researcher

Professor John Holloway PhD, FHEA

Associate V-P Interdisciplinary Research

Research interests

  • Human genetics
  • Epigenetics
  • Respiratory Disease
Connect with John

Research outputs

Ayoung Jeong, Ikenna C. Eze, Danielle Vienneau, Kees De Hoogh, Dirk Keidel, Thomas Rothe, Luc Burdet, John W. Holloway, Debbie Jarvis, Florian Kronenberg, Gianfranco Lovison, Medea Imboden & Nicole Probst-hensch, 2021, Environment International, 158, 106945
Type: article
Nicole Probst-Hensch, Ayoung Jeong, Daiana Stolz, Marco Pons, Paola M Soccal, Robert Bettschart, Deborah Jarvis, John W Holloway, Florian Kronenberg, Medea Imboden, Christian Schindler & Gianfranco F Lovison, 2021, Frontiers in Public Health, 9, 584955
Type: article
Medea Imboden, Matthias Wielscher, Faisal I. Rezwan, André F.S. Amaral, Emmanuel Schaffner, Ayoung Jeong, Anna Beckmeyer-Borowko, Sarah E. Harris, John M. Starr, Ian J. Deary, Claudia Flexeder, Melanie Waldenberger, Annette Peters, Holger Schulz, Su Chen, Shadia Khan Sunny, Wilfried J.J. Karmaus, Yu Jiang, Gertraud Erhart, Florian Kronenberg, Ryan Arathimos, Gemma C. Sharp, Alexander John Henderson, Yu Fu, Paivi Piirila, Kirsi H. Pietiläinen, Miina Ollikainen, Åsa Johansson, Ulf Gyllensten, Maaike de Vries, Diana A. van der Plaat, Kim de Jong, H. Marike Boezen, Ian P. Hall, Martin D. Tobin, Marjo-Riitta Jarvelin, John Holloway, Deborah Jarvis & Nicole M. Probst-Hensch, 2019, European Respiratory Journal, 54(1)
Type: article
Anna Beckmeyer-Borowko, Medea Imboden, Faisal I. Rezwan, Matthias Wielscher, Andre F.S. Amaral, Ayoung Jeong, Emmanuel Schaffner, Juha Auvinen, Sylvain Sebert, Ville Karhunen, Robert Bettschart, Alexander Turk, Marco Pons, Daiana Stolz, Florian Kronenberg, Ryan Arathimos, Gemma C. Sharp, Caroline Relton, Alexander J. Henderson, Marjo-Riitta Jarvelin, Deborah Jarvis, John W. Holloway & Nicole M. Probst-Hensch, 2018, Respiratory Research, 19(1), 1-14
Type: article
Toril Mørkve Knudsen, Faisal I. Rezwan, Yu Jiang, Wilfried Karmaus, Cecilie Svanes & John W. Holloway, 2018, Journal of Allergy and Clinical Immunology, 142(3), 765-772
Type: article