Open menu
View all research projects
Research project

Ageing Lungs in European Cohorts (ALEC Study)

Project overview

This project aims to improve our understanding of the determinants and risk factors for low lung function, respiratory disability and the development of chronic obstructive lung disease (COPD), through exploitation of information held within existing cohorts and their population–based biobanks. Even though COPD has long been viewed as a predominantly smoking-related disease, more than 30% of people with COPD have never smoked, and there is increasing awareness that other risk profiles must contribute to disease. COPD is a major cause of disease, disability and death in European adults and lung function is a critical objective marker of good lung health, strongly associated with other major chronic diseases (for example, cardiovascular disease) and is a major independent determinant of overall health status (physical and mental health, quality of life, exercise capacity, independent living).

Staff

Lead researcher

Professor John Holloway PhD, FHEA

Associate V-P Interdisciplinary Research

Research interests

  • Human genetics
  • Epigenetics
  • Respiratory Disease

Research outputs

A three-generation study on the association of tobacco smoking with asthma
Simone Accordini,
Lucia Calciano,
Ane Johannessen,
Laura Portas,
Bryndis Benediktsdóttir,
Randi Jacobsen Bertelsen,
Lennart Bråbäck,
Anne-elie Carsin,
Shyamali C Dharmage,
Julia Dratva,
Bertil Forsberg,
Francisco Gomez Real,
Joachim Heinrich,
John Holloway,
Mathias Holm,
Christer Janson,
Rain Jögi,
Bénédicte Leynaert,
Andrei Malinovschi,
Alessandro Marcon,
Jesús Martínez-moratalla Rovira,
Chantal Raherison,
José Luis Sánchez-ramos,
Vivi Schlünssen,
Roberto Bono,
Angelo G. Corsico,
Pascal Demoly,
Sandra Dorado Arenas,
Dennis Nowak,
Isabelle Pin,
Joost Weyler,
Deborah Jarvis,
& Cecilie Svanes
, 2018 , International Journal of Epidemiology , 47 (4) , 1106--1117
DOI: 10.1093/ije/dyy031
Type: article
Trans- and inter-generational epigenetic inheritance in allergic diseases
Toril Mørkve Knudsen,
Faisal I. Rezwan,
Yu Jiang,
Wilfried Karmaus,
Cecilie Svanes,
& John W. Holloway
, 2018 , Journal of Allergy and Clinical Immunology , 142 (3) , 765--772
DOI: 10.1016/j.jaci.2018.07.007
Type: article
Zoonotic helminth exposure and risk of allergic diseases: a study of two generations in Norway
Nils Oskar Jõgi,
Cecilie Svanes,
Silver Peeter Siiak,
Erin Logan,
John W. Holloway,
Jannicke Igland,
Ane Johannessen,
Michael Levin,
Francisco Gomez Real,
Vivi Schlunssen,
William G.C. Horsnell,
& Randi J. Bertelsen
, 2018 , Clinical & Experimental Allergy , 48 (1) , 66--77
DOI: 10.1111/cea.13055
Type: article
Systematic review of lung function and COPD with peripheral blood DNA methylation in population based studies
Matthew Machin,
André F.S. Amaral,
Matthias Wielscher,
Faisal I. Rezwan,
Medea Imboden,
Marjo-Riitta Jarvelin,
Ian M. Adcock,
Nicole Probst-Hensch,
John W. Holloway,
Deborah L. Jarvis,
&
, 2017 , BMC Pulmonary Medicine , 17 (54)
DOI: 10.1186/s12890-017-0397-3
Type: article
Back
to top