Research project

Core Capability for Chemistry Research in Southampton - Brown - EPSRC

Lead researchers:

Professor Richard Brown
Other researchers:

Professor Gill Reid
Research funder:

EPSRC
Status:

Not active

Staff

Lead researchers

Professor Richard Brown

Professor of Organic Chemistry

Research interests

Organic synthesis
Total synthesis of natural products
Asymmetric synthesis

Connect with Richard

Email: R.C.Brown@soton.ac.uk

Other researchers

Professor Gill Reid

PROFESSOR OF CHEMISTRY

Research interests

Synthetic inorganic chemistry
Design and synthesis of new macrocyclic and multidentate ligands involving donor atoms from G…
Coordination chemistry with s-, p-, d- and f-block metal ions

Connect with Gill

Email: G.Reid@soton.ac.uk

Research outputs

Cellular activity upregulation of the thermolabile p53 cancer mutant Y220C by small molecule indazole derivatives

Raniya Khadiullina, Vitaly Chasov, Elvina Gilyazova, Damir Davletshin, Regina Mirgayazova, Rimma Mingaleeva, Joseph Richard Stephenson Clarke, Matthias G.J. Baud & Emil Bulatov, 2025, Cell Death and Discovery, 11(1)

DOI: 10.1038/s41420-025-02781-6

Type: article

Photocyclisations of o-iodobenzyl-indanonesand tetralones infer the intermediacyof triplet aryl cations

Marian Elise Powderly, Toby Lindup, Edward Henry Jackman, Mark Light, Julien Legros, Isabelle Chataigner & David C. Harrowven, 2025, ChemComm

DOI: 10.1039/D5CC05185A

Type: article

Methyl on the bridge: 2-methyl propellane as precursor for 1,3-substituted 2-methylated bicyclo[1.1.1]pentanes"

Sean R. Verschaeve, Mariana Gomes Manso, Tibo Van Eeckhoorn, Mark E. Light & Bruno Linclau, 2025, Chemistry - A European Journal

DOI: 10.1002/chem.202502396

Type: article

In pursuit of larger lipophilicity enhancement: an investigation of sugar deoxychlorination

2025, Organic & Biomolecular Chemistry, 23(11), 2586-2589

DOI: 10.1039/D5OB00037H

Type: article

Practicable syntheses of electroluminescent ionic 2,2′-bifluorenes

Edward H. Jackman, Oliver J. Ward, Yi Li, Katie L. Court, Robert C. Carroll, Simon J. Coles, Stephen P. Beeby, Isabelle Chataigner, Julien Legros & David C. Harrowven, 2024, European Journal of Organic Chemistry, 27(48)

DOI: 10.1002/ejoc.202400976

Type: article

De Novo enantioselective synthesis of hexafluorinated d-glucose

Sébastien Depienne, Clement Q Fontenelle, Mark Light, Kristof Van Hecke & Bruno Linclau, 2024, Journal of Organic Chemistry, 89(19), 14291-14304

DOI: 10.1021/acs.joc.4c01724

Type: article

Exploring 2-sulfonylpyrimidine warheads as acrylamide surrogates for targeted covalent inhibition: a BTK story

Ruxandra Moraru, Beatriz Valle-Argos, Annabel Minton, Lara Buermann, Suyin Pan, Thomas E. Wales, Raji E. Joseph, Amy H. Andreotti, Jonathan C. Strefford, Graham Packham & Matthias G.J. Baud, 2024, Journal of Medicinal Chemistry, 67(16), 13572-13593

DOI: 10.1021/acs.jmedchem.3c01927

Type: article