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Research project

D Boche ARUK - Impact of Systemic Inflammation due to infection on Microglia Phenotype

Staff

Lead researcher

Professor Delphine Boche

Professor of Neuroimmunopathology

Research interests

  • Neuroimmunology and neurodegeneration
  • Immunophenotyping immune cells
  • Human brain pathology
Other researchers

Emeritus Professor Clive Holmes

Professor James Nicoll

Research outputs

Acute systemic inflammation exacerbates neuroinflammation in Alzheimer’s Disease: IL-1β drives amplified responses in primed astrocytes and neuronal network dysfunction
Ana Belen Lopez-Rodriguez,
Edel Hennessy,
Carol Murray,
Arshed Nazmi,
Hugh J Delaney,
Daire Healy,
Steven Fagan,
Michael Rooney,
Erika Stewart,
Anouchka Lewis,
Niamh de Barra,
Philip Scarry,
Louise Riggs-Miller,
Delphine Boche,
Mark Cunnigham,
& Colm Cunnigham
, 2021 , Alzheimer's & Dementia , 17 (10)
DOI: 10.1002/alz.12341
Type: article
Systemic infection modifies the neuroinflammatory response in late stage Alzheimer’s disease
Sonja Rakic,
Yat M.A. Hung,
Matthew Smith,
Denise So,
Hannah Tayler,
William Varney,
Joe Wild,
Scott Harris,
Clive Holmes,
Seth Love,
William Stewart,
James Nicoll,
& Delphine Boche
, 2018 , Acta Neuropathologica Communications , 6 (88)
DOI: 10.1186/s40478-018-0592-3
Type: article
Innate immunity in Alzheimer's disease
Diana K. Franco Bocanegra,
James A.R. Nicoll,
& Delphine Boche
, 2017 , Journal of Neural Transmission , 20
DOI: 10.1007/s00702-017-1729-4
Type: article
What do we know about the inflammasome in humans?
Jay Amin,
Delphine Boche,
& Sonja Rakic
, 2017 , Brain Pathology , 27 (2) , 192--204
DOI: 10.1111/bpa.12479
Type: article
The effect of non-steroidal anti-inflammatory agents on behavioural changes and cytokine production following systemic inflammation: implications for a role of COX-1
J.L. Teeling,
C. Cunningham,
Tracey A. Newman,
& V.H. Perry
, 2010 , Brain, Behavior and Immunity , 24 (3) , 409--419
DOI: 10.1016/j.bbi.2009.11.006
Type: article
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