Research project

D Boche ARUK - Impact of Systemic Inflammation due to infection on Microglia Phenotype

Lead researchers:

Professor Delphine Boche
Other researchers:

Emeritus Professor Clive Holmes,

Professor James Nicoll
Research funder

Alzheimers Research UK
Status:

Not active

Staff

Lead researchers

Professor Delphine Boche

Professor of Neuroimmunopathology

Research interests

Neuroimmunology and neurodegeneration
Immunophenotyping immune cells
Human brain pathology

Connect with Delphine

Email: D.Boche@soton.ac.uk

Other researchers

Emeritus Professor Clive Holmes

Connect with Clive

Email: C.Holmes@soton.ac.uk

Professor James Nicoll

Connect with James

Email: J.Nicoll@soton.ac.uk

Research outputs

Systemic infections alter cortical transcriptional signatures in Alzheimer’s disease

Giulia Pegoraro, Lachlan F. MacBean, Adam R. Smith, Darren M. Soanes, Rebecca G. Smith, Jennifer Imm, Joshua Harvey, Morteza Kouhsar, Valentin Laroche, Luke Weymouth, Isabel Castanho, Winston Hide, Laura Palmer, Debra J. Lett, Andrew C. Robinson, Natalie Woodman, Karina McDade, Delphine Boche, Ehsan Pishva & Katie Lunnon, 2026, Neurobiology of Aging, 167, 155-167

DOI: 10.1016/j.neurobiolaging.2026.06.010

Type: article

Acute systemic inflammation exacerbates neuroinflammation in Alzheimer’s Disease: IL-1β drives amplified responses in primed astrocytes and neuronal network dysfunction

Ana Belen Lopez-Rodriguez, Edel Hennessy, Carol Murray, Arshed Nazmi, Hugh J Delaney, Daire Healy, Steven Fagan, Michael Rooney, Erika Stewart, Anouchka Lewis, Niamh de Barra, Philip Scarry, Louise Riggs-Miller, Delphine Boche, Mark Cunnigham & Colm Cunnigham, 2021, Alzheimer's & Dementia, 17(10)

DOI: 10.1002/alz.12341

Type: article

Systemic infection modifies the neuroinflammatory response in late stage Alzheimer’s disease

Sonja Rakic, Yat M.A. Hung, Matthew Smith, Denise So, Hannah Tayler, William Varney, Joe Wild, Scott Harris, Clive Holmes, Seth Love, William Stewart, James Nicoll & Delphine Boche, 2018, Acta Neuropathologica Communications, 6(88)

DOI: 10.1186/s40478-018-0592-3

Type: article

Innate immunity in Alzheimer's disease

Diana K. Franco Bocanegra, James A.R. Nicoll & Delphine Boche, 2017, Journal of Neural Transmission, 20

DOI: 10.1007/s00702-017-1729-4

Type: article

What do we know about the inflammasome in humans?

Jay Amin, Delphine Boche & Sonja Rakic, 2017, Brain Pathology, 27(2), 192-204

DOI: 10.1111/bpa.12479

Type: article

The effect of non-steroidal anti-inflammatory agents on behavioural changes and cytokine production following systemic inflammation: implications for a role of COX-1

J.L. Teeling, C. Cunningham, Tracey A. Newman & V.H. Perry, 2010, Brain, Behavior and Immunity, 24(3), 409-419

DOI: 10.1016/j.bbi.2009.11.006

Type: article

A double dissociation between the effects of sub-pyrogenic systemic inflammation and hippocampal lesions on learning

David J. Sanderson, Colm Cunningham, Robert M.J. Deacon, David M Bannerman, V. Hugh Perry & J. Nicholas P. Rawlins, 2009, Behavioural Brain Research, 201(1), 103-111

DOI: 10.1016/j.bbr.2009.01.038

Type: article