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Research project

D Boche ARUK - Impact of Systemic Inflammation due to infection on Microglia Phenotype

Staff

Lead researcher

Professor Delphine Boche

Professor of Neuroimmunopathology

Research interests

  • Delphine serves on a range of neuroscience research projects focusing on neuroinflammation and neurodegeneration.
  • Her main research interest is to develop a greater understanding of the role of neuroinflammation in relation with ageing, neurological diseases and systemic inflammation, using the approaches of human brain analysis. Her research focuses on microglia, the immune cells of the brain, where she has developed protocols to immunophenotype microglia in humans using markers relating to a specific function allowing us to investigate the role of these cells in different neurological conditions.
  • Her work is located at the junction between clinical neurodegenerative disease, human neuropathology and experimental neuroscience where she has developed an expertise in neuroimmunopathology
Other researchers

Emeritus Professor Clive Holmes

Collaborating research institutes, centres and groups

Clinical Neurosciences

Examining how clinical and environmental factors can affect brain development.

Research outputs

Acute systemic inflammation exacerbates neuroinflammation in Alzheimer’s Disease: IL-1β drives amplified responses in primed astrocytes and neuronal network dysfunction
Ana Belen Lopez-Rodriguez,
Edel Hennessy,
Carol Murray,
Arshed Nazmi,
Hugh J Delaney,
Daire Healy,
Steven Fagan,
Michael Rooney,
Erika Stewart,
Anouchka Lewis,
Niamh de Barra,
Philip Scarry,
Louise Riggs-Miller,
Delphine Boche,
Mark Cunnigham,
& Colm Cunnigham
, 2021 , Alzheimer's & Dementia , 17 (10)
DOI: 10.1002/alz.12341
Type: article
Systemic infection modifies the neuroinflammatory response in late stage Alzheimer’s disease
Sonja Rakic,
Yat M.A. Hung,
Matthew Smith,
Denise So,
Hannah Tayler,
William Varney,
Joe Wild,
Scott Harris,
Clive Holmes,
Seth Love,
William Stewart,
James Nicoll,
& Delphine Boche
, 2018 , Acta Neuropathologica Communications , 6 (88)
DOI: 10.1186/s40478-018-0592-3
Type: article
Innate immunity in Alzheimer's disease
Diana K. Franco Bocanegra,
James A.R. Nicoll,
& Delphine Boche
, 2017 , Journal of Neural Transmission , 20
DOI: 10.1007/s00702-017-1729-4
Type: article
What do we know about the inflammasome in humans?
Jay Amin,
Delphine Boche,
& Sonja Rakic
, 2017 , Brain Pathology , 27 (2) , 192--204
DOI: 10.1111/bpa.12479
Type: article
The effect of non-steroidal anti-inflammatory agents on behavioural changes and cytokine production following systemic inflammation: implications for a role of COX-1
J.L. Teeling,
C. Cunningham,
Tracey A. Newman,
& V.H. Perry
, 2010 , Brain, Behavior and Immunity , 24 (3) , 409--419
DOI: 10.1016/j.bbi.2009.11.006
Type: article
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