Research
Research groups
Research interests
- Examining the profile of neuroinflammation in Dementia with Lewy bodies
- Permeability of the blood-brain barrier in Alzheimer’s disease (PEBBAL) measured using dynamic contrast-enhanced MRI
- Diagnostic biomarkers of gut microbiome-associated phenotypes predictive of healthy aging and neurodegenerative disease (BIO-AGE)
- Use of electronic patient records to explore clinical features and outcomes in Dementia with Lewy bodies
Current research
Dr Amin’s research interests focus on the role of inflammation in Dementia with Lewy bodies, Alzheimer’s disease and other neurodegenerative conditions. This includes exploration of the role of cerebral inflammatory markers in post-mortem brain tissue, and peripheral inflammatory markers using techniques such as multiplex immunoassay and flow cytometry.
Clinically, Dr Amin’s interests are in improving quality of life and outcomes in people living with dementia, and their carers.
Dr Amin is also principal investigator for several commercial and non-commercial clinical trials at the Memory Assessment and Research Centre in Southampton. These include drug trials testing novel agents in Alzheimer’s disease, Dementia with Lewy bodies and Mild Cognitive Impairment
Research projects
Completed projects
Publications
Supervision
Current PhD Students
Teaching
Lead for Psychiatry/Addictions module for BM5 Year 2, University of Southampton
External roles and responsibilities
Biography
Dr Amin is an Associate Professor in Psychiatry of Older Age within Medicine at the University of Southampton. His research focus is on the role of inflammation in Dementia with Lewy bodies, Alzheimer’s disease and other neurodegenerative conditions. He is principal investigator for several commercial and non-commercial clinical trials in dementia and mild cognitive impairment at the Memory Assessment and Research Centre in Southampton.
Dr Amin graduated from medical school at Southampton in 2007 and completed his foundation programme training within Wessex. He undertook an NIHR Academic Clinical Fellowship between 2009-2012, following which he was awarded an Alzheimer’s Research UK Clinical Research Fellowship. His PhD project explored the role of inflammation in Dementia with Lewy bodies and Alzheimer’s disease, using both patient cohorts and post-mortem human brain tissue. Dr Amin joined the specialist medical register for Old Age Psychiatry after completing his higher clinical training in 2018.
In 2019 Dr Amin was appointed to his current role as Associate Professor in Psychiatry of Older Age for the University of Southampton. He is also an honorary consultant in Old Age Psychiatry at Southern Health NHS Foundation Trust, where he conducts memory clinics including providing a tertiary service for people with Dementia with Lewy bodies or Parkinson’s disease dementia.