Dr Amin’s research interests focus on the role of inflammation in Lewy body dementia, Alzheimer’s disease, and other neurodegenerative conditions. This includes exploration of the role of cerebral inflammatory markers in post-mortem human brain tissue, and peripheral inflammatory markers using techniques such as multiplex immunoassay and flow cytometry.
Clinically, Dr Amin’s interests are in improving the quality of life and outcomes of people living with dementia, and their carers. Dr Amin is principal investigator for several commercial and non-commercial clinical trials at the Memory Assessment and Research Centre in Southampton (marctrials.org). These include drug trials testing novel agents in Alzheimer’s disease, Dementia with Lewy bodies and Mild Cognitive Impairment.
- Developing our understanding of the role of inflammation in Lewy body dementia and Alzheimer's disease, including how it affects disease progression.
- Undertaking cohort studies exploring clinical outcomes in dementia.
- Undertaking clinical trials testing novel treatments in dementia.
- Examining the role of inflammation on clinical progression in Dementia with Lewy bodies (funded by the Lewy Body Society).
- Examining the role of blood-brain barrier permeability and inflammation on clinical progression in Alzheimer's disease (funded by Alzheimer's Society).
- Combination treatment for dementia with Lewy Bodies and Parkinson's disease dementia (COBALT, funded by NIHR HTA grant).
- Determining the profile of cerebral T cells in Dementia with Lewy bodies (funded by University of Southampton Research Management Committee).
- Development of a structured deprescribing intervention for people with dementia or mild cognitive impairment in primary care (STOP-DEM, funded by NIHR ARC Wessex).
2019-2023: Lead for psychiatry teaching in the nervous system module in BM5 Year 2, University of Southampton.
2023-current: Lead for psychiatry in BMedSc research module, University of Southampton.
External roles and responsibilities
Dr Amin is an Associate Professor in Psychiatry of Older Age within Medicine at the University of Southampton. His research focus is on the role of inflammation in Lewy body dementia, Alzheimer’s disease and other neurodegenerative conditions. He is principal investigator for several commercial and non-commercial clinical trials in dementia and mild cognitive impairment at the Memory Assessment and Research Centre in Southampton (marctrials.org).
Dr Amin graduated from medical school at Southampton in 2007 and completed his foundation programme training within Wessex. He undertook an NIHR Academic Clinical Fellowship between 2009-2012, following which he was awarded an Alzheimer’s Research UK Clinical Research Fellowship. His PhD project explored the role of inflammation in Dementia with Lewy bodies and Alzheimer’s disease, using both patient cohorts and post-mortem human brain tissue. Dr Amin joined the specialist medical register for Old Age Psychiatry after completing his higher clinical training in 2018.
In 2019 Dr Amin was appointed to his current role as Associate Professor in Psychiatry of Older Age for the University of Southampton. He is also an honorary consultant in Old Age Psychiatry at Southern Health NHS Foundation Trust, where he conducts memory clinics including providing a tertiary service for people with Dementia with Lewy bodies or Parkinson’s disease dementia.