About
Dr Amin’s research interests focus on the role of inflammation in Lewy body dementia, Alzheimer’s disease, and other neurodegenerative conditions. This includes exploration of the role of cerebral inflammatory markers in post-mortem human brain tissue, and peripheral inflammatory markers using techniques such as multiplex immunoassay and flow cytometry.
Clinically, Dr Amin’s interests are in improving quality of life and outcomes in people living with dementia, and their carers. Dr Amin is principal investigator for several commercial and non-commercial clinical trials at the Memory Assessment and Research Centre (MARC) in Southampton. These include drug trials testing novel agents in Alzheimer’s disease, Dementia with Lewy bodies and Mild Cognitive Impairment. He also leads a tertiary memory clinic service based within MARC.
Research
Research groups
Research interests
- Developing our understanding of the role of inflammation in Lewy body dementia and Alzheimer's disease, including how it affects disease progression.
- Undertaking cohort studies exploring biomarkers and clinical outcomes in dementia.
- Undertaking clinical trials testing novel treatments in dementia.
Current research
- Lewy body dementia doctoral training network (LBD-DTN, funded by the Alzheimer's Society).
- Examining the role of inflammation on clinical progression in dementia with Lewy bodies (funded by the Lewy Body Society).
- Examining the role of blood-brain barrier permeability and inflammation on clinical progression in Alzheimer's disease (funded by Alzheimer's Society).
- Combination treatment for dementia with Lewy Bodies and Parkinson's disease dementia (COBALT, funded by NIHR HTA).
- Determining the profile of cerebral T cells in Dementia with Lewy bodies (funded by University of Southampton Research Management Committee).
Research projects
Active projects
Completed projects
Publications
Teaching
2019-2023: Lead for psychiatry teaching in the nervous system module in BM5 Year 2, University of Southampton.
2023-current: Psychiatry field lead for the BM5 Year 3 research project module, University of Southampton.
External roles and responsibilities
Biography
Dr Amin is an Associate Professor in Psychiatry of Older Age within Medicine at the University of Southampton. His research focus is on the role of inflammation in Lewy body dementia, Alzheimer’s disease and other neurodegenerative conditions. He is principal investigator for several commercial and non-commercial clinical trials in dementia and mild cognitive impairment at the Memory Assessment and Research Centre in Southampton.
Dr Amin graduated from medical school at Southampton in 2007 and completed his foundation programme training within Wessex. He undertook an NIHR Academic Clinical Fellowship between 2009-2012, following which he was awarded an Alzheimer’s Research UK Clinical Research Fellowship. His PhD project explored the role of inflammation in dementia with Lewy bodies and Alzheimer’s disease, using patient cohorts and post-mortem human brain tissue. Dr Amin joined the specialist medical register for Old Age Psychiatry after completing his higher clinical training in 2018.
In 2019, Dr Amin was appointed to his current role as Associate Professor in Psychiatry of Older Age for the University of Southampton. He is also an honorary consultant in Old Age Psychiatry at Hampshire and Isle of Wight Healthcare NHS Foundation Trust, where he leads a tertiary memory clinic service.
Prizes
- Alzheimer's Research UK Clinical Research Fellowship (2014)
- Alzheimer's Research UK Clinical Research Fellowship (2014)
- Mohsen Naguib Prize (2017)