Research project

Investigation of novel adjunctive therapies to improve treatment success in paediatric middle ear infection (otitis media)

Lead researchers:

Professor Saul Faust
Other researchers:

Professor Rami J. Salib,

Professor Jeremy Webb
Research funder:

Sparks Children's Medical Research Charity
Status:

Not active

Project overview

Innovation and patient benefit grant from Spark’s Children’s medical Research Charity.

Staff

Lead researchers

Professor Saul Faust MBBS, PhD, FRCPCH, FFPM(Hon), FHEA, OBE

Professor Paediatric Immunology & Infect

Connect with Saul

Email: s.faust@soton.ac.uk

Other researchers

Professor Rami J. Salib BMedSci, BMBS, DLO, FRCS, FRCS(ORL-HNS), PhD

Professor of Rhinology

Research interests

1- Elucidation of mechanisms of disease resistance in Staphylococcus aureus-mediated chronic rhinosinusitis. 2- Use of the nose to develop novel biomarkers to enable early detection and monitoring of dementia (collaboration with the Carare Research Group). 3- Characterisation of the sinonasal microbiome and its diversity in adult Primary Ciliary Dyskinesia, and its impact on upper airway disease severity (collaboration with the PCD Group).

Connect with Rami J.

Email: R.J.Salib@soton.ac.uk

Professor Jeremy Webb

Professor of Microbiology

Research interests

Microbial biofilms and their control
Adaptive biology and evolution of microorganisms
Biofilm-associated infection

Connect with Jeremy

Email: J.S.Webb@soton.ac.uk

Research outputs

Cephalosporin-NO-donor prodrug PYRRO-C3D shows β-lactam-mediated activity against Streptococcus pneumoniae biofilms

Raymond Allan, Michael J. Kelso, Ardeshir Rineh, Nageshwar R. Yepuri, Martin Feelisch, Odel Soren, Sanjita Brito-Mutunayagam, Rami Salib, Paul Stoodley, Stuart C. Clarke, Jeremy Webb, Luanne Hall-Stoodley & Saul Faust, 2017, Nitric Oxide, 65, 43-49

DOI: 10.1016/j.niox.2017.02.006

Type: article