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Research project

TISuMR: Integrated Tissue Slice Culture and NMR Metabolomics – A Novel Approach Towards Systemic

  • Research groups:
  • Lead researcher:
    Professor Marcel Utz
  • Research funder:
    European Union
  • Status:
    Not active

Project overview

This international collaboration, led by Southampton, aims to provide a radically new technological platform for the integrated culture and NMR observation of liver tissue slices, with the immediate objective to elucidate the mechanism of liver damage by cholestasis.

Staff

Lead researcher

Professor Marcel Utz

Professorial Fellow-Research

Research interests

  • Integration of microfluidic lab-on-a-chip technology with NMR spectroscopy and imaging;
  • Behaviour of complex materials.

Collaborating research institutes, centres and groups

Magnetic Resonance

Our main focus is finding ways to extend the timescale over which magnetic resonance can be made.

Research outputs

Fully automated characterization of protein-peptide binding by microfluidic 2D NMR
Marek Plata,
Manvendra Sharma,
Marcel Utz,
& Jörn M. Werner
, 2022 , Journal of the American Chemical Society , 145 (5) , 3204–3210
DOI: 10.1021/jacs.2c13052
Type: article
Synergies between hyperpolarized NMR and microfluidics: a review
James Eills,
William G Hale,
& Marcel Utz
, 2021 , Progress in Nuclear Magnetic Resonance Spectroscopy
DOI: 10.1016/j.pnmrs.2021.09.001
Type: review
Kinetic investigation of a cucurbit[7]uril-based pseudo[6]rotaxane system by microfluidic nuclear magnetic resonance
Yibin Sun,
Hongxun Fang,
Xujing Lin,
Xiuxiu Wang,
Ganyu Chen,
Xinchang Wang,
Zhongqun Tian,
Liulin Yang,
Marcel Utz,
& Xiaoyu Cao
, 2021 , Chemistry , 2021 (3) , 948–956
DOI: 10.31635/ccschem.021.202100773
Type: article
Microfluidic platform for serial mixing experiments with in operando nuclear magnetic resonance spectroscopy
Marek Plata,
William G Hale,
Manvendra Sharma,
Jorn Werner,
& Marcel Utz
, 2021 , Lab on a Chip , 21 (8) , 1598--1603
DOI: 10.1039/D0LC01100B
Type: article
Time-resolved non-invasive metabolomic monitoring of a single cancer spheroid by microfluidic NMR
Bishnubrata Patra,
Manvendra Sharma,
William G Hale,
& Marcel Utz
, 2021 , Scientific Reports , 11 (1)
DOI: 10.1038/s41598-020-79693-1
Type: article
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