Research project

J A Ratnayaka: Study of molecular mechanisms driving RPE dysfunction in patients from different stages of AMD

Lead researchers:

Dr Arjuna Ratnayaka
Research funder:

Macular Disease Society
Status:

Not active

Staff

Lead researchers

Dr Arjuna Ratnayaka

Associate Professor

Connect with Arjuna

Email: J.Ratnayaka@soton.ac.uk

Research outputs

A high fat "Western-style" diet induces AMD-like features in Wildtype mice

Eloise Keeling, Savannah A Lynn, Yen Min Koh, Jenny A Scott, Aaron Kendall, Maureen Gatherer, Anton Page, Felino R Cagampang, Andrew J Lotery & J Arjuna Ratnayaka, 2022, Molecular Nutrition & Food Research, 66(11), e2100823

DOI: 10.1002/mnfr.202100823

Type: article

Serial block face scanning electron microscopy reveals novel organizational details of the retinal pigment epithelium

J Arjuna Ratnayaka & Eloise Keeling, 2022, Neural Regeneration Research, 17(3), 569-571

DOI: 10.4103/1673-5374.321002

Type: article

Challenges in studying geographic atrophy (GA) age-related macular degeneration: the potential of a new mouse model with GA-like features

J. Arjuna Ratnayaka & Andrew Lotery, 2020, Neural Regeneration Research, 15(5), 863-864

DOI: 10.4103/1673-5374.268972

Type: article

Oxidative stress and dysfunctional intracellular traffic linked to an unhealthy diet results in impaired cargo transport in the Retinal Pigment Epithelium (RPE)

Eloise Keeling, David Chatelet, David Johnston, Anton Page, David Tumbarello, Andrew Lotery & J. Arjuna Ratnayaka, 2019, Molecular Nutrition & Food Research, 63(15)

DOI: 10.1002/mnfr.201800951

Type: article

Modelling Sorsby’s Fundus Dystrophy using patient-derived iPSC-RPE

Jennifer Dewing, David RG Christensen, Heidi Hongisto, Jennifer Scott, Ben Jenkins, Angela Cree, Heli Skottman, J. Arjuna Ratnayaka & Andrew Lotery, 2019, Investigative Ophthalmology & Visual Science, 60

Type: conference

A lasered mouse model of retinal degeneration displays progressive outer retinal pathology providing insights into early geographic atrophy

Paul Ibbett, Srinivas V. Goverdhan, Elena Pipi, Joe Kirit Chouhan, Eloise Keeling, Elizabeth M. Angus, Jenny Scott, Maureen Gatherer, Anton Page, Jessica Teeling, Andrew Lotery & J. Arjuna Ratnayaka, 2019, Scientific Reports, 9

DOI: 10.1038/s41598-019-43906-z

Type: article