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Doctor David Tumbarello

Dr David Tumbarello

Lecturer in Biomedical Sciences

Research interests

  • Membrane Trafficking
  • Autophagy
  • Mitochondrial Quality Control

More research

Accepting applications from PhD students.


I obtained my PhD while working in the lab of Prof Chris Turner at SUNY Upstate Medical University in Syracuse, New York investigating the role of focal adhesion proteins during epithelial-mesenchymal transformation and their influence on cytoskeletal rearrangement during cell migration/invasion. Following on from this, I was a postdoctoral fellow with Cancer Research UK at the Cambridge Institute in Cambridge, UK working in the lab of Prof James Brenton investigating the mechanisms of cell-extracellular matrix interactions and their relationship to therapeutic resistance in ovarian cancer. Following on from this, I was a Research Associate at the CIMR in Cambridge, UK working in the lab of Prof Folma Buss interrogating the function of actin motor proteins and associated adaptor proteins in autophagy, a cytoplasmic degradation pathway. More specifically, this work has defined how autophagy receptor specificity towards distinct cargo is coordinated and what determines their individual cellular role. I joined Biological Sciences at the University of Southampton as a Lecturer and Group Leader in Biomedical Sciences in 2014, where our group is interested in investigating areas of endosomal adaptor function, autophagy, and mitochondrial quality control.

Tumbarello Lab Webpage