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Research project

Mechanisms of long-range retrograde signal propogation - Deinhardt - BBSRC

Staff

Lead researcher

Professor Katrin Deinhardt

Professor

Research interests

  • Our research is focused on cellular and molecular neurobiology. Fascinated by the beautiful but complicated shape of individual neurons, we study the complex intracellular logistics required to form, maintain and remodel these cells throughout life.Neurons extend processes that cover vast territories, which allow them to directly connect with cells distant from the soma. Our research interest is to understand how neurons integrate the different extracellular cues that they receive at distinct parts of the cell in time and space to maintain and adapt their structure and connectivity. To this end, we investigate the interplay of short- and long-range trafficking and signalling, and how these events ultimately converge to initiate changes in neuronal morphology and physiology in health and neurodegeneration.
  • Lab webpage
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Collaborating research institutes, centres and groups

Neuroscience

We work on national and global priorities of health and well-being, underpinning research in neuroscience, and age-related neurodegenerative diseases, including Alzheimer’s.

Research outputs

Quantitative and correlative extreme ultraviolet coherent imaging of mouse hippocampal neurons at high resolution
Peter Baksh,
Michal Odstrčil,
Magdalena Miszczak,
Charles Pooley,
Richard Chapman,
Adam Wyatt,
Emma Springate,
John Chad,
Katrin Deinhardt,
Jeremy G. Frey,
& William Brocklesby
, 2020 , Science Advances , 6 (18)
DOI: 10.1126/sciadv.aaz3025
Type: article
A 5′ UTR GGN repeat controls localisation and translation of a potassium leak channel mRNA through G-quadruplex formation
Connor Maltby,
James Schofield,
Steven Houghton,
Ita O'Kelly,
Mariana Vargas-Caballero,
Katrin Deinhardt,
& Mark Coldwell
, 2020 , Nucleic Acids Research , 48 (17) , 9822--9839
DOI: 10.1093/nar/gkaa699
Type: article
Co-culture of murine neurons using a microfluidic device for the study of Tau misfolding propagation
Grace Hallinan,
Dianne Lopez,
Mariana Vargas-caballero,
Jonathan West,
& Katrin Deinhardt
, 2020 , Bio-protocol , 10 (16)
DOI: 10.21769/BioProtoc.3718
Type: article
A primate-specific short GluN2A-NMDA receptor isoform is expressed in the human brain
Mariana Vargas-Caballero,
Hannah, Kate Warming,
Chrysia-Maria Pegasiou,
Aleksandra, Paulina Pitera,
Hanna Kariis,
Steven Houghton,
Ksenia Kurbatskaya,
Aminul Ahmed,
Paul Grundy,
Girish V. Vajramani,
Diederik Bulters,
Xavier Altafaj,
& Katrin Deinhardt
, 2019 , Molecular Brain , 12 (1) , 1--8
DOI: 10.1186/s13041-019-0485-9
Type: article
Proteomic approaches to dissect neuronal signalling pathways
Heather Bowling,
Shruti Nayak,
& Katrin Deinhardt
, 2019
DOI: 10.1007/978-3-030-15950-4_27
Type: bookChapter
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