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Project overview

Chest infections are a common reason for people to see their GP. Most such infections are caused by viruses and don’t need antibiotics. However, it can be difficult to tell the difference between viral and bacterial infections. Many patients are therefore prescribed antibiotics unnecessarily. Overuse of antibiotics is leading to a crisis of ‘antibiotic resistance’, where antibiotics no longer work for some infections.

FebriDx® is a new single-use, hand-held test that uses a ‘finger-prick’ of blood, and within 10 minutes, provides a result that can help clinicians decide whether an infection is likely to be caused by a virus or bacteria (https://www.febridx.com/Home/Europe)
In this ‘feasibility’ study, we would like to see whether FebriDx could be used to safely guide antibiotic treatment and reduce the number of antibiotics prescribed in general practice. We would also like to explore how easy to use the FebriDx test is, and what staff and patients think of the test, in order to help us design a larger future study.

Data will be collected in GP practices from patients presenting with chest infections who agree to undergo testing with FebriDx®. We will also undertake optional follow-up interviews with staff and patients.
Aims1) Explore the possibility of using FebriDx to safely reduce the use of antibiotics for chest infections in primary care.2) Explore how feasible it would be to do a large research study in the future using FebriDx in GP practices, and how we should design this study.
Co-Principal Investigators: Dr Christopher Wilcox
https://www.southampton.ac.uk/medicine/about/staff/cw8g15.page
Professor Nick Francis
Co-applicants: Dr Tristan Clark, Professor Paul Little, Dr Ingrid Muller, Dr Beth Stuart, Dr Nazrul Islam, Dr Taeko Becque

Funder: NIHR School for Primary Care Research (Project 633)
Duration: 3 October 2022 - 2 October 2023

Contact: prefix@soton.ac.uk
This study is being conducted by the Primary Care Research Centre.
https://www.southampton.ac.uk/primarycare

Staff

Lead researcher

Professor Nick Francis

Clinical Professor of Primary Care Res

Research interests

  • Infections in primary care
  • Antimicrobial stewardship

Connect with Nick

Other researchers

Professor Tristan Clark

Professor of Infectious Diseases

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Professor Paul Little

Professor in Primary Care Research

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Doctor Ingrid Muller BSc, MSc, PhD, CPsychol, FHEA

Associate Professor

Research interests

  • Self-management of long-term conditions
  • Behavioural health interventions

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Doctor Nazrul Islam MBBS, MSc, MPH, PhD

Associate Professor

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Doctor Taeko Becque

Senior Clinical Trials Statistician

Research interests

  • Medical statistics
  • Randomised trials

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