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Research project

S Pugh - MRC - MR/M018423/1 - The role of miR-31 in regulating response of colorectal cancer to EGFR inhibition

Staff

Other researchers

Professor Alex Mirnezami

Professor of Surgical Oncology

Professor Gareth Thomas

Professor of Experimental Pathology

Research interests

  • Fibroblast biology and immunology
  • Tumour microenvironment
  • Cancer Immunotherapy

Dr Emre Sayan

Associate Professor

Research interests

  • - The link between EMT and apoptosis/therapy resistance.
  • - Mechanobiology of EMT: How tumour stiffness associates with EMT and creates tumour microenvironment.
  • - How EMT influences non-cancer cells in tumour microenvironment (e.g. T cell recruitment or fibroblast-myofibroblast differentiation).

Collaborating research institutes, centres and groups

Cancer Sciences

Our research works towards improving treatment for patients with cancer.

Research outputs

Systemic chemotherapy with or without cetuximab in patients with resectable colorectal liver metastasis (New EPOC): long-term results of a multicentre, randomised, controlled, phase 3 trial
John Bridgewater,
Siân A. Pugh,
Tom Maishman,
Zina Eminton,
Jane M. Mellor,
Amy Whitehead,
Louise Stanton,
Michael Radford,
Andrea Corkhill,
Gareth Griffiths,
Stephen Falk,
Juan Valle,
Derek O'Reilly,
Ajith K. Siriwardena,
Joanne Hornbuckle,
Myrddin Rees,
Timothy Iveson,
Tamas Hickish,
O. James Garden,
David Cunningham,
Timothy Maughan,
John Primrose,
&
, 2020 , Lancet Oncology , 21 (3) , 398--411
DOI: 10.1016/S1470-2045(19)30798-3
Type: article
The diagnostic accuracy of a single CEA blood test in detecting colorectal cancer recurrence: results from the FACS trial
Bethany Shinkins,
Brian D. Nicholson,
John Primrose,
Rafael Perera,
Timothy James,
Sian Pugh,
& David Mant
, 2017 , PLoS ONE , 12 (3)
DOI: 10.1371/journal.pone.0171810
Type: article
Association between miR-31-3p expression and cetuximab efficacy in patients with KRAS wild-type metastatic colorectal cancer
Sian Pugh,
Raphaele Thiebaut,
John Bridgewater,
Marie-Lise Grisoni,
Karwan Moutasim,
Francis Rousseau,
Gareth Thomas,
Gareth Griffiths,
Francois Liebaert,
John Primrose,
& Pierre Laurent-Puig
, 2017 , Oncotarget
DOI: 10.18632/oncotarget.21291
Type: article
Patterns of progression, treatment of progressive disease and post-progression survival in the New EPOC study
Sian A. Pugh,
Megan Bowers,
Alexandre Ball,
Stephen Falk,
Meg Finch-Jones,
Juan W. Valle,
Derek A. O'Reilly,
Ajith K. Siriwardena,
Joanne Hornbuckle,
Myrddin Rees,
Charlotte Rees,
Tim Iveson,
Tamas Hickish,
Tom Maishman,
Louise Stanton,
Elizabeth Dixon,
Andrea Corkhill,
Mike Radford,
O. James Garden,
David Cunningham,
Tim S. Maughan,
John A. Bridgewater,
& John N. Primrose
, 2016 , British Journal of Cancer , 115 , 420--424
DOI: 10.1038/bjc.2016.208
Type: article
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