Natural products biosynthesis: a complex cascade of catalytic steps in vitamin B6 biosynthesis is characterised by structures or reaction intermediates in the large PLP syntase complexEdit
Bacterial biofilms: understanding of RedOx regulated phosphodiesterase activity in dispersal of biofilms to address chronic infections
We explore how molecular interactions between proteins and small molecules, defined at atomic resolution, govern biochemical output and in turn control cell behaviour.
We develop environmentally sustainable approaches to chemical manufacture that minimise chemical waste, improve product velocity and reduce the need to isolate intermediates.