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The University of Southampton
Biological Sciences

Research project: DNA sequence recognition by small molecules

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We are using the footprinting technique with natural and synthetic DNA substrates to study the sequence selectivity of novel DNA binding small molecules.

Many natural and synthetic ligands bind to DNA and recognize sequences of between 2-4 base pairs. We are using the footprinting technique with natural and synthetic DNA substrates to study the sequence selectivity of various natural and synthetic DNA fragments. Since the footprinting technique is limited by the sequences that are present in any given restriction fragment we have devised novel methods for assessing sequence selectivity and have designed synthetic DNA fragments which contain all possible tetranucleotide sequences and all symmetrical hexanucleotide sequences.

Related research groups

Molecular and Cellular Biosciences

Key Publications

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