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The University of Southampton
Chemistry
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(023) 8059 9369
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est@soton.ac.uk

Dr Eugen Stulz PhD

Associate Professor in Bio-organic and Materials Chemistry

Dr Eugen Stulz's photo

Dr Eugen Stulz is Associate Professor in Bio-organic and Materials Chemistry with a focus on DNA chemistry and nanomaterials for biological/medicinal and energy applications.

Always expect the unexpected (JKMS)

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Eugen Stulz graduated from the University of Bern (Switzerland) in 1994, where he subsequently studied for a Ph.D. under the supervision of Prof. Christian J. Leumann. His thesis was concerned with the evaluation of artificial nucleases based on zirconium(iv) complexes and sponsored from the Basel Chemical Industry. In 1999, he moved to Cambridge (UK) as a Swiss National Science Foundation (SNSF) Postdoctoral fellow to the group of Prof. Jeremy K. M. Sanders, working in the field of supramolecular chemistry and dynamic combinatorial libraries using phosphine-substituted porphyrins. During this time, he also held a part-time teaching position at Anglia Polytechnic University, and an SNSF Advance Research position. In 2003, he moved to the University of Basel (Switzerland) as a Lecturer and started his independent research in the field of DNA bio-nanotechnology. In 2006, he was appointed Lecturer in Chemistry at the University of Southampton, promoted Senior Lecturer in 2010 and Associate Professor in 2014.

Eugen has been author of several invited review articles (CEJ; CSR; Acc. Chem. Res.), invited book chapter contributions (Struct. Bond.; Porphyrin Handbook), and has been invited editor of a special theme issue on DNA nanotechnology in CSR in 2011. In 2003 he was also awarded the SYNTHESIS/SYNLETT Journal Award by Thieme, Germany. A Wiley book on DNA nanotechnology was published in 2015, which was co-edited with Guido Clever (Dortmund). Eugen Stulz also featured several times in the Swiss Radio (SRF 1), on local TV (ITV Meridian special edition; ITV Meridian News), in professional reviews (KTN; Chem. World; EPSRC Mass Spectrometry Centre Swansea; DLS) and in the Vietnamese press. He has been invited lecturer in Trieste (2013) and invited professor in Bordeaux (2015).

Our UG project and PhD students regularly win prizes for their work, most notably the Roscoe Medal at Set for Britain 2010, NanoKTN prize, Merck poster prize, John Mellor project prize, and EPSRC Award for Young Scientists. The work of the UG project students often leads to publications.

 

 

 

 

 

Molecular Diognostics and Therapeutics
Click on image to enlarge

The general research interests in the Stulz group are concerned with supramolecular chemistry, bio-nanotechnology, medicinal chemistry, nanoparticles and microfluidics.

We are mainly exploring the use of modified DNA in a number of applications, ranging from electronics over gene expression to novel platform technologies in health care. The research is highly interdisciplinary, and reaches into materials science, nanotechnology, analytical science, and into biological / medicinal sciences. We have reviewed the recent progress in the use of modified DNA in Chem. Soc. Rev. 2011, in Chem. Eur. J. 2012 and in Acc Chem Res 2017.

In addition, we are investigating in the synthesis of silver nanoprisms for energy applications. We have shown that Ag-NPs can successfully be embedded in a polymer matrix and coated onto glass windows, thus forming an IR-light blocking layer to create more energy efficient windows. One of our main themes is now to develop 3D-printed flow-through reactors for continuous flow reactor synthesis of Ag-NPs, which can also be applied to other nanoparticles (e.g. liposomes). The costs of a device is now as low as £5.

 

Research keywords

DNA nanotechnology, DNA nanoarchitectonics, supramolecular chemistry, DNA origami, porphyrins, nucleotide therapeutics

Research grants

2014-2018 A*STAR ARAP and UoS “Development of a modular DNAorigami based cell targeting system for cancer therapy”; E. Stulz, P. L Bigliardi (CRUSAR/IMB Singapore), M. Bigliardi-Qi (IMB Singapore), B. Rout, Brendan Burkett (ICES Singapore). (£90k)                    

2013-2015 Marie Skłodowska-Curie IEF “Functional DNA nanomaterials”. (€231k)

2012-2017 BBSRC sLoLa “Extending the Boundaries of Nucleic Acid Chemistry”; E. Stulz, K. Fox, A. Tavassoli; Oxford: T. Brown (PI), A. Turberfield, J. Mellor, R. Klose, E. Fodor, A. Kapanidis. (£4.2M)

2012-2016 A*STAR ARAP and UoS “Chemically Tagged DNA probes for sensing of DNA methylation biomarkers using Lab-on-a-chip; E. Stulz, M. K. Park (IME Singapore). (£85k)

2012-2015 EU Interreg “A-I Chem Channel” D.C. Harrowven, R.C.D. Brown, B. Linclau, R.J. Whitby, R. Raja, E. Stulz, P.A. Gale. (£614k)

2012-2013 USRG NanoScience “Validation of structure and theoretical model of chemically modified DNA”; E. Stulz, S. Khalid. (£15k)

2011-2013 Leverhulme Trust “Sizing forensic nucleotide repeat sequences with nanopores”; E. Stulz, S. Howorka (UCL). (£113k)

2010-2012 EPSRC “Feasibility Account: DNA nano-biotechnology”; E. Stulz, A. Turberfield (Oxford). (£252k)

2008-2012 BBSRC DTA “G-quadruplexes stabilised by porphyrins”. (£84k)

2008-2011 EPSRC “Molecular Software and Hardware for Programmed Chemical Synthesis”; E. Stulz, A. Turberfied (Oxford), R. O’Reilly (Warwick). (£271k)

2007-2010 EPSRC CASE DTA with ATDbio, “FRET-Analysis of DNA using conformationally restricted metal complexes”. (£63k)

2007-2010 EPSRC “Software-controlled assembly of oligomers”; E. Stulz, A. Turberfied (Oxford), R. O’Reilly (Warwick). (£203k)

PhD Students:

Lauren L. Entwistle (née Sargisson) - Development of a modular DNA-origami based cell targeting system for cancer therapy (University PGR Scholarship / A*STAR ARAP Singapore)

D. Andrea Cristaldi - 3D printed continuous flow reactors for nanomaterial synthesis (EPSRC Centre for Doctoral Training in Energy Storage and its Applications)

Ane Gutierrez Aguirregabiria - LNA-DNA chimeras targeting IRES for in vivo manipulation and monitoring of gene expression for imaging and cancer therapy (Hilary Marsden IfLS PhD Studentship / University PGR Scholarship)

Christina Xyrafaki - Determining surface oriented SRCD signatures of proteins on DNA origami ti (Diamond Light Source / UoS EPSRC CASE)

Ting Shi - Targeting cMYC using modified DNA

 

Affiliated University of Southampton Research groups:

Bioengineering Science.

Institute for Life Sciences.

 

Other affiliated research groups:

Prof. Xunli Zhang

https://www.southampton.ac.uk/engineering/about/staff/xz1f06.page

Dr Mark J Coldwell

https://www.southampton.ac.uk/engineering/about/staff/xz1f06.page

Prof. Graham Packham

https://www.southampton.ac.uk/medicine/about/staff/gpackham.page

Dr Tilman Sanchez-Elsner

https://www.southampton.ac.uk/medicine/about/staff/tse1v07.page

Research group

Chemical Biology, Diagnostics and Therapeutics

Research project(s)

Stulz: DNA bio-nanotechnology

DNA bio-nanotechnology

Stulz: Chemistry-Biology-Medicine interface

Chemistry-Biology-Medicine interface.

Stulz: DNA origami

DNA Origami.

Stulz: Flow through reactors

Flow through reactors.

Member of the Institute for Life Sciences.

Invited member of the EPSRC Peer Review College.

Member of the BBSRC Pool of Experts.

Invited member of Diamond Light Source B23 Steering Committee.

Invited member of Diamond Light Source Peer Review Panel (Soft Matter).

Invited member Editorial Board Cogent Chemistry, Cogent OA Publishers, Taylor & Francis.

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Key Publications

Articles

Book Chapter

Review

Module Coordinator:
CHEM3004 Organic Materials Chemistry
CHEM6093 Materials Chemistry

Lecturer:
CHEM2001 Organic Reaction Mechanisms
NATS2002 Editing Life
CHEM6145 Supramolecular Chemistry of Functional Molecules and Materials

Tutor:
CHEM1031 Fundamentals of Organic Chemistry I
CHEM1032 Fundamentals of Organic Chemistry II
CHEM2001 Organic Reaction Mechanisms
CHEM2005 Aspects of Organic Synthesis

Demonstrator:
CHEM1031  Yr1_L5 lab

Advisor/examiner/assessor:
CHEM6102 Chemistry Placement

Examiner:
CHEM6140 Advanced chemistry – distance learning

Assessor:
CHEM3012 Chemistry Research Project 
CHEM6089 Advanced Research Project for MChem Students

Supervisor/Examiner:
CHEM6090 Chemistry Research Project and Dissertation

Supervisor/Assessor:
CHEM6142 MSc Research Project Instrumental Analytical Chemistry 

 

 

Dr Eugen Stulz
Chemistry University of Southampton Highfield Southampton SO17 1BJ

Room Number: 30/5028

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