Chemical Engineering for the Pharmaceutical Sector

Learning Outcomes

Disciplinary Specific Learning Outcomes

Having successfully completed this module you will be able to:

• Evaluate the use of process control, catalysis and reaction to optimise current pharmaceutical processing practices. (Practice);
• Apply and evaluate concepts and limitations of chemical engineering drug processing (Practice)
• Evaluate the effects of uncertainty in the production of pharmaceutical products and devise strategies to mitigate the risks of such uncertainty (Depth)
• Reflect on the sustainability and impact of current and emerging processes. (Emerging technologies);
• Analyse the parameters required for a complete life cycle analysis in the context of water use and energy in pharmaceutical sectors and technology. (Design)
• Assess the impacts of health and safety, with respect to current legal requirements. (Breadth) ;

Subject Specific Practical Skills

Having successfully completed this module you will be able to:

• Select and utilise appropriate chemical engineering tools to model complex Heat and Mass transfer processes. (Design);
• Evaluate the outcomes of risk assessments for a series of case studies of pharmaceutical production processes (Breadth)

Subject Specific Intellectual and Research Skills

Having successfully completed this module you will be able to:

• Select and design unit operations appropriate to the manufacture of specific classes of pharmaceutical products

Knowledge and Understanding

Having successfully completed this module, you will be able to demonstrate knowledge and understanding of:

• Discuss the stages of the formulation process with reference to case studies
• Extend and apply knowledge of design practices to describe the primary operating parameters in current pharmaceutical industries;

UNIT I - INTRODUCTION Development of drugs and pharmaceutical industry; Organic therapeutic agents uses and Economics; Drug Metabolism and Pharmaco Kinetics; Drug Metabolism: Physio Chemical principles; Radioactivity; Pharma kinetic reaction of Drugs on Human bodies. In depth understanding of the environmental and safety aspects processing operations. UNIT II - IMPORTANT UNIT PROCESS AND THEIR APPLICATIONS Chemical conversion processes; Alkylation; Carboxylation; Condensation & Cyclisation; Dehydration; Esterification; Halogenation; Oxidation; Sulfonation; Complex Chemical conversions; Fermentation. UNIT III - MANUFACTURING PRINCIPLES & EMULSIONS Compressed Tablets; Wet granulation - dry granulation or slugging; Direct compression Tablet Presses Formulation; Coating Pills; Capsules; Sustained dosage Forms; Parental Solution; Oral liquids - Injections External preparations - Ointments; Standard of Hygiene and Good Manufacturing practice as per Drugs & Cosmetics Act as amended update. UNIT IV - PHARMACEUTICAL PRODUCTS FORMULATIONS Based on Antipyretic & anti inflammatory, Respiratory, Cardio intestinal & Liver, Hormones, C.N.S Stimulants, Histamine and Anti Histamine, Vitamins and other nutrients, Sedatives, Analgesics. Computational Chemistry and drug analysis UNIT V - MICROBIOLOGICAL & ANIMAL PRODUCTS Antibiotics, Anti Infective, Biological, Hormones, Vitamins and Preservation, Pharmaceutical Analysis, Analytical methods and Tests for various Drugs and Pharmaceuticals, Packing Techniques, Quality Control.

Teaching is by a combination of formal lectures augmented by problem solving sessions

Summative

This is how we’ll formally assess what you have learned in this module.