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Professor Raimund Ober MPhil, PhD

Professor of Imaging and Biomedical Engineering

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The Ober laboratory is run jointly with the laboratory of Professor Sally Ward. The research is directed towards taking a highly interdisciplinary approach to generate effective therapeutics for autoimmunity and cancer. This involves a combination of antibody/protein engineering, fluorescence microscopy and in vivo studies in mouse models of disease

Raimund Ober is a Professor of Imaging and Biomedical Engineering in the Centre for Cancer Immunology. His research interests relate to the development and application of engineering principles to problems in molecular/cellular biology, cancer therapeutics and immunology.

Of particular interest is the development of new microscopy techniques and, more specifically, single molecule microscopy approaches. His theoretical and experimental investigations of the classical resolution problem showed that there is no resolution limit in a microscope, but that distances well below those estimated by Rayleigh’s criterion can be resolved.

He has pioneered the development of a new microscopy modality, multifocal plane microscopy, to enable the study of fast cellular transport processes in three dimensions. Using microscopy and other techniques, his research group and collaborators investigate the dynamics and transport of new therapeutics and their interactions with their target proteins in a cellular context; for example, engineered antibodies that target tumour cells. The main areas of application are cancer biology and immunology, autoimmunity, etc. They also have studied the molecular basis for the transport of therapeutic agents to specific subcellular compartments and related questions in pharmacokinetics.

Qualifications

‘Vordiplom in Mathematik’, ‘Zwischenpruefung in Physik’, Tuebingen University, Germany, 1982
Certificate of Advanced Study in Mathematics, Cambridge University, UK, 1984
M.Phil. in Operations Research and Control Engineering, Department of Engineering, Cambridge University, 1985
PhD, Department of Engineering, Cambridge University, UK, 1987

Appointments held

1987-1990: Research Fellowship at Girton College, Cambridge, UK and Department of Engineering, Cambridge University, UK

1990-1993: Assistant Professor, Programs in Mathematical Sciences, Center for Engineering Mathematics, University of Texas at Dallas

1993-1997: Associate Professor with tenure, Programs in Mathematical Sciences and Department of Electrical Engineering, University of Texas at Dallas

1996-: Adjunct Faculty Appointment, University of Texas Southwestern Medical Center, Dallas

1997-1998: Full Professor with tenure, Programs in Mathematical Sciences and Department of Electrical Engineering, University of Texas at Dallas

1999-2014: Full Professor with tenure, Department of Electrical Engineering, University of Texas at Dallas

2005-2014: Member, Graduate Program in Biomedical Engineering, University of Texas Southwestern Medical Center at Dallas

2008-2014: Member, Faculty of Department of Molecular and Cell Biology, University of Texas at Dallas

2010-2014: Member, Faculty of Department of Bioengineering, University of Texas at Dallas

2014-2018: Full Professor, Department of Biomedical Engineering and Department of Cellular and Molecular Medicine, Texas A&M University

2018-current: Professor of Imaging and Biomedical Engineering, Centre for Cancer Immunology, University of Southampton

Research interests

The Ober laboratory is run jointly with the laboratory of Professor Sally Ward.

The research is directed towards taking an interdisciplinary approach to generate effective therapeutics for autoimmunity and cancer. This involves a combination of antibody/protein engineering, fluorescence microscopy and in vivo studies in mice.

Research group

Cancer Sciences

Affiliate research group

Centre for Cancer Immunology

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Wellcome Trust

Scheme: Joint Investigator Award
Title: Defining the Fc receptor-mediated trafficking of IgG-antigen complexes in macrophages
Role on Project: Co-Principal Investigator
Joint Principal Investigators:  Raimund Ober PhD and E. Sally Ward PhD.
Period: June 2018 – June 2025

Cancer Research UK

Scheme: Drug Discovery Committee – Biotherapeutics Drug Discovery Programme Award
Title: Next generation antibody-drug conjugates for cancer therapy
Role on Project: Co-Principal Investigator
Joint Principal Investigators: Raimund Ober PhD and E. Sally Ward PhD.
Period: February 2019 – February 2024

Professor Raimund Ober
Centre for Cancer Immunology
Faculty of Medicine (MP 127)
University of Southampton

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