Professor Raimund Ober MPhil, PhD
Professor of Imaging and Biomedical Engineering
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The Ober laboratory is run jointly with the laboratory of Professor Sally Ward. The research is directed towards taking a highly interdisciplinary approach to generate effective therapeutics for autoimmunity and cancer. This involves a combination of antibody/protein engineering, fluorescence microscopy and in vivo studies in mouse models of disease
Raimund Ober is a Professor of Imaging and Biomedical Engineering in the Centre for Cancer Immunology. His research interests relate to the development and application of engineering principles to problems in molecular/cellular biology, cancer therapeutics and immunology.
Of particular interest is the development of new microscopy techniques and, more specifically, single molecule microscopy approaches. His theoretical and experimental investigations of the classical resolution problem showed that there is no resolution limit in a microscope, but that distances well below those estimated by Rayleigh’s criterion can be resolved.
He has pioneered the development of a new microscopy modality, multifocal plane microscopy, to enable the study of fast cellular transport processes in three dimensions. Using microscopy and other techniques, his research group and collaborators investigate the dynamics and transport of new therapeutics and their interactions with their target proteins in a cellular context; for example, engineered antibodies that target tumour cells. The main areas of application are cancer biology and immunology, autoimmunity, etc. They also have studied the molecular basis for the transport of therapeutic agents to specific subcellular compartments and related questions in pharmacokinetics.
Qualifications
‘Vordiplom in Mathematik’, ‘Zwischenpruefung in Physik’, Tuebingen University, Germany, 1982
Certificate of Advanced Study in Mathematics, Cambridge University, UK, 1984
M.Phil. in Operations Research and Control Engineering, Department of Engineering, Cambridge University, 1985
PhD, Department of Engineering, Cambridge University, UK, 1987
Appointments held
1987-1990: Research Fellowship at Girton College, Cambridge, UK and Department of Engineering, Cambridge University, UK
1990-1993: Assistant Professor, Programs in Mathematical Sciences, Center for Engineering Mathematics, University of Texas at Dallas
1993-1997: Associate Professor with tenure, Programs in Mathematical Sciences and Department of Electrical Engineering, University of Texas at Dallas
1996-: Adjunct Faculty Appointment, University of Texas Southwestern Medical Center, Dallas
1997-1998: Full Professor with tenure, Programs in Mathematical Sciences and Department of Electrical Engineering, University of Texas at Dallas
1999-2014: Full Professor with tenure, Department of Electrical Engineering, University of Texas at Dallas
2005-2014: Member, Graduate Program in Biomedical Engineering, University of Texas Southwestern Medical Center at Dallas
2008-2014: Member, Faculty of Department of Molecular and Cell Biology, University of Texas at Dallas
2010-2014: Member, Faculty of Department of Bioengineering, University of Texas at Dallas
2014-2018: Full Professor, Department of Biomedical Engineering and Department of Cellular and Molecular Medicine, Texas A&M University
2018-current: Professor of Imaging and Biomedical Engineering, Centre for Cancer Immunology, University of Southampton