The Genomic Informatic group, led by Dr Tapper, specialises in identifying novel germline and somatic variants which influence the risk of developing disease and clinical outcomes and how this knowledge can be translated into improved diagnosis, risk prediction and personalised treatment. The group uses a wide range of bioinformatic and statistical techniques to analyse large-scale genetic datasets including next generation sequencing (NGS), genome-wide association studies (GWAS), polygenic risk scores (PRS), Mendelian randomisation, network analysis, data integration and machine learning.
- Long term follow-up of the POSH cohort to determine disease risks for distant, locoregional and new primary disease in young-onset breast cancer patients with known BRCA1/2 mutation status
- Genome-wide association study of outcome after aneurysmal subarachnoid haemorrhage
- Developing a polygenic risk score for pancreatic cancer
- Utilising multiomic data to understand therapy resistance in paediatric rhabdomyosarcomas
- Utilising patient omic information to identify target mechanisms of resistance in sarcomas
- Genomics of food allergy and food allergen sensitisation
Dr Tapper is the Module lead for 'Genomic Technologies and Basic Informatics' and 'Genomic Informatics' for the MSc in Genomics. He delivers lectures for several modules, supervises MSc, PhD and iPhD students and marks their research projects.
Dr Tapper contributes to undergraduate teaching of Medicine (BM5) via his role as the Head of Feild for Genetics and as a Personal Academic tutor. He also supervises and marks third year student projects.