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Professor Diana Eccles

Professor Diana Eccles

Dean of Medicine

Research interests

  • Genetic predispostion to cancer
  • Cancer susceptibility variant interpetation and clinical application
  • Patient communication to optimise shared decision making

More research


Diana Eccles graduated in Medicine from Manchester University in 1983, her clinical training is in general medicine, oncology and clinical genetics and she has worked and trained in Manchester, Edinburgh and Southampton. Her research background is in molecular genetics and genetic epidemiology, her doctoral thesis investigated the molecular genetics of ovarian cancer working in the MRC Human Genetics Unit in Edinburgh, she was awarded her MD in 1992. Previous roles at UoS include Director of the Southampton Clinical Trials Unit (2009-2014) and Head of Cancer Sciences (2015-2018). She contributes to national and international scientific evaluations and peer review including currently the UKRI REF evaluation panel (Main panel A, SP1), MRC CARP (chair) and Research Council of Norway Centres of Excellence panel. Her research focuses on genetic predispostion to cancer and management of hereditary breast cancer She is CI of the UK Prospective study of Outcomes in Sporadic versus Hereditary breast cancer (POSH study) and Co-CI of CanGene-CanVar CRUK Catalyst programme (2019-2024) to improve the interpretation and clinical translation of genetic variants in cancer predisposition genes.