About
Ivo Tews uses crystallography to study molecular interactions. Particular intrests are in large dynamic macromolecular complexes and time resolved techniques that are applied in immunology, developing novel cancer therapies, and in enzymology.
As chair of the CCP4 project he is involved in software development and use of AI for modern crystallography. He is engaged in then national Digital Reserach Infrastructure (DRI), charinig integrated computing for molecular biology in DRI-IMB, and in synchrotron science at the Diamond Light Source and the European Synchtrotron Radiation Facilty.
Research
Research groups
Research interests
- Cancer immunology, where a structure based approach to rational drug development is applied for novel cancer therapies.
- Natural products biosynthesis to study vitamin B6 biosynthesis by the large PLP syntase complex.
- Bacterial biofilms: understanding of RedOx regulated phosphodiesterase activity in dispersal of biofilms to address chronic infections.
Research projects
Active projects
Researchers:
Researchers:
Sponsor: Cancer Research UK
Completed projects
Researchers:
Researchers:
Sponsor: Science And Technology Facilities Council
Sponsor: Medical Research Council
Researchers:
Researchers:
Sponsor: Cancer Research UK
Researchers:
Sponsor: Wessex Medical Research
Publications
81 publications
Page 3 of 9
Sam Horrell, Danny Axford, Nicholas E. Devenish, Ali Ebrahim, Michael A. Hough, Darren A. Sherrell, Selina L.S. Storm, Ivo Tews, Jonathan A.R. Worrall & Robin L. Owen,
2021, JoVE Journal, 2021(168), 1
DOI: 10.3791/62200
Type: article
Yu-Ming Cai, Andrew Hutchin, Jack Craddock, Martin A Walsh, Jeremy S. Webb & Ivo Tews,
2020, Scientific Reports, 10(1), 1-12
Type: article
Muchaala Yeboah, Charys Papagregoriou, Des C. Jones, Hak Chan, Guangan Hu, Justine McPartlan, Christopher Mockridge, Ivo Tews, Martin Glennie, Stephen Thirdborough, Mark Cragg & Ali Roghanian,
2020, JCI Insight, 5(18)
Type: article
Marina Lučić, Dimitri A. Svistunenko , Michael T. Wilson, Amanda K. Chaplin, Bradley Davy, Ali Ebrahim, Danny Axford, Takehiko Tosha, Hiroshi Sugimoto, Shigeki Owada, Florian S. N Dworkowski, Ivo Tews, Robin L. Owen, Michael A. Hough & Jonathan A. R. Worrall,
2020, Angewandte Chemie International Edition, 59(48), 21656–21662
Type: article
Xiaojie Yu, H. T.Claude Chan, Hayden Fisher, Christine A. Penfold, Jinny Kim, Tatyana Inzhelevskaya, C. Ian Mockridge, Ruth R. French, Patrick J. Duriez, Leon R. Douglas, Vikki English, J. Sjef Verbeek, Ann L. White, Ivo Tews, Martin J. Glennie & Mark S. Cragg,
2020, Cancer Cell, 37(6), 850-866.e7
Type: article
Jeremy Webb, Dom Bellini, Andrew Hutchin, Odel Soren, Ivo Tews & Martin A. Walsh,
2020
Type: bookChapter
Selina L S Storm, Adam D Crawshaw, Nicholas E Devenish, Rachel Bolton, David R Hall, Ivo Tews & Gwyndaf Evans,
2020, IUCrJ, 7(Part 1), 129-135
Type: article
John H. Beale, Rachel Bolton, Stephen A. Marshall, Emma V. Beale, Stephen B. Carr, Ali Ebrahim, Tadeo Moreno-Chicano, Michael A. Hough, Jonathan A.R. Worrall, Ivo Tews & Robin L. Owen,
2019, Journal of Applied Crystallography, 52(Pt 6), 1385-1396
Type: article
Maria Victoria Humbert, Alexandra Jackson, Christian M. Orr, Ivo Tews & Myron Christodoulides,
2019, Scientific Reports, 9(1), 1-14
Type: article
Greta Reintjes, Halina E. Tegetmeyer, Miriam Bürgisser, Sandi Orlić, Ivo Tews, Mikhail Zubkov, Daniela Voß, Oliver Zielinski, Christian Quast, Frank Oliver Glöckner, Rudolf Amann, Timothy G. Ferdelman & Bernhard M. Fuchs,
2019, Applied and Environmental Microbiology, 85(14), 1-14
DOI: 10.1128/AEM.00184-19
Type: article
Biography
Prizes
- David Blow Prize (2011)
- PD, venia legendi (2011)
- David Blow Prize (2011)
- PD, venia legendi (2011)