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Research project

Developing immunostimulatory antibodies to deliver agonism without toxicity

Staff

Lead researchers

Professor Aymen Al-Shamkhani

Professor in Immunology
Research interests
  • Cancer Immunotherapy
  • Immunobiology of costimulatory receptors
  • Immunostimulatory antibodies
Connect with Aymen

Email: A.Al-Shamkhani@soton.ac.uk

Other researchers

Professor Jonathan Essex

Professor
Research interests
  • Molecular simulations of biological systems
  • Computer aided drug discovery
  • Method development in molecular simulations
Connect with Jonathan

Email: J.W.Essex@soton.ac.uk

Professor Mark Cragg

Professor in Experimental Cancer Biology
Research interests
  • Antibody biology
  • Antibody engineering
  • Cancer Immunotherapy
Connect with Mark

Email: M.S.Cragg@soton.ac.uk

Professor Stephen Beers

Professor of Immunology & Immunotherapy
Connect with Stephen

Email: S.A.BEERS@soton.ac.uk

Professor Peter Johnson CBE MD FRCP FMedSci

Professor of Medical Oncology
Connect with Peter

Email: johnsonp@soton.ac.uk

Dr Ali Roghanian PhD, FHEA

Associate Professor
Research interests
  • Cancer immunotherapy
  • Monoclonal antibodies
  • Cellular therapies (e.g., CAR T and iNKT cells)
Connect with Ali

Email: A.Roghanian@soton.ac.uk

Professor Ivo Tews

Professor
Research interests
  • Natural products biosynthesis: a complex cascade of catalytic steps in vitamin B6 biosynthesis is characterised by structures or reaction intermediates in the large PLP syntase complexEdit
  • Bacterial biofilms: understanding of RedOx regulated phosphodiesterase activity in dispersal of biofilms to address chronic infections
  • Cancer immunology: together with Cancer Immunology at Southampton we use a structure based apporach in developing novel cancer therapie
Connect with Ivo

Email: Ivo.Tews@soton.ac.uk

Collaborating research institutes, centres and groups

Research outputs