About
Ivo Tews uses crystallography to study molecular interactions. Particular intrests are in large dynamic macromolecular complexes and time resolved techniques that are applied in immunology, developing novel cancer therapies, and in enzymology.
As chair of the CCP4 project he is involved in software development and use of AI for modern crystallography. He is engaged in then national Digital Reserach Infrastructure (DRI), charinig integrated computing for molecular biology in DRI-IMB, and in synchrotron science at the Diamond Light Source and the European Synchtrotron Radiation Facilty.
Research
Research groups
Research interests
- Cancer immunology, where a structure based approach to rational drug development is applied for novel cancer therapies.
- Natural products biosynthesis to study vitamin B6 biosynthesis by the large PLP syntase complex.
- Bacterial biofilms: understanding of RedOx regulated phosphodiesterase activity in dispersal of biofilms to address chronic infections.
Research projects
Active projects
Researchers:
Researchers:
Sponsor: Cancer Research UK
Completed projects
Researchers:
Researchers:
Sponsor: Science And Technology Facilities Council
Sponsor: Medical Research Council
Researchers:
Researchers:
Sponsor: Cancer Research UK
Researchers:
Sponsor: Wessex Medical Research
Publications
81 publications
Page 8 of 9
Ivo Tews, Felix Findeisen, Irmgard Sinning, Anita Schultz, Joachim E Schultz & Jürgen U Linder,
2005, Science, 308(5724), 1020-1023
Type: article
Christian Schlieker, Ivo Tews, Bernd Bukau & Axel Mogk,
2004, FEBS Letters, 578(3), 351-356
Type: article
Götz Hofhaus, Jeung Eun Lee, Ivo Tews, Beate Rosenberg & Thomas Lisowsky,
2003, European Journal of Biochemistry, 270(7), 1528-1535
Type: article
Edward D Lowe, Ivo Tews, Kin Yip Cheng, Nick R Brown, Sheraz Gul, Martin E M Noble, Steven J Gamblin & Louise N Johnson,
2002, Biochemistry, 41(52), 15625-15634
DOI: 10.1021/bi0268910
Type: article
S. Sato, I. Tews & R. J.M. Wilson,
2000, International Journal for Parasitology, 30(4), 427-439
Type: article
Ivo Tews, Anke C. Terwisscha Van Scheltinga, Anastassis Perrakis, Keith S. Wilson & Bauke W. Dijkstra,
1997, Journal of the American Chemical Society, 119(34), 7954-7959
DOI: 10.1021/ja970674i
Type: article
C. E. Vorgias, A. Perrakis & I. Tews,
1996, Annals of the New York Academy of Sciences, 799, 190-192
Type: article
Ivo Tews, A. Perrakis, A. Oppenheim, Z. Dauter, K. S. Wilson & C. E. Vorgias,
1996, Nature Structural Biology, 3(7), 638-648
Type: article
Ivo Tews, Renauld Vincentelli & Constantin E. Vorgias,
1996, Gene, 170(1), 63-67
Type: article
A Perrakis, I Tews, Z Dauter, A B Oppenheim, I Chet, K S Wilson & C E Vorgias,
1994, Structure, 2(12), 1169-1180
Type: article
Biography
Prizes
- David Blow Prize (2011)
- PD, venia legendi (2011)
- David Blow Prize (2011)
- PD, venia legendi (2011)