Bioinformatics Research Facility (BIO-R)

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About the Bioinformatics Research Facility (BIO-R)

The Bioinformatics Research Facility (BIO-R) is based in the Faculty of Medicine’s Somers building at the hospital campus. The BIO-R serves as a centralised resource for providing expert bioinformatics consulting and data analysis solutions. Investigators from within and outside the Faculty of Medicine on both grant-funded and chargeback-based projects for the analysis of large-scale biological datasets produced by high-throughput ‘omics’ experiments can use the service.
The BIO-R’s mission is to build and maintain an infrastructure that provides access to bioinformatics expertise to enable research, enhance impact, and serve as a collaborative research hub.

  • provides a core team of skilled bioinformaticians, with up-to-date training and the latest data analysis methods
  • provides a milestone-led, and sustainable service delivery model to provide users with workplans for data processing and analytical delivery
  • facilitates access to state-of-the-art high-performance computing through the IRIDIS infrastructure, and relevant software packages and pipelines
  • contributes to the educational portfolio of the faculty, providing training to users at all levels of expertise (including external clients)

Technical specification

  • Single-cell omics analysis (ScRNA-seq, scATAC-seq, etc.)
  • Spatial transcriptomics (10x Visium, CosMx, GeoMx etc.)
  • RNA-seq analysis (QC, normalized gene expression, differential gene expression, pathway analysis,GSEA,Transcript quantifiation, Alternate Splicing)
  • Small RNA-seq analysis (e.g. miRNAs, circRNAs, eRNAs, etc.)
  • ChIP-seq/ATAC-seq analysis (e.g. QC, peak calling, differential binding)
  • Variant calling from long and short read sequencing data
  • Epigenomics Analysis (DNA methylation)
  • TCRseq/BCRseq Analysis

Contact Us

Contact us

Somers Building, University of Southampton, University Hospital Southampton, Tremona Road,Southampton, SO16 6YD, United Kingdom
We’re open Monday to Friday 09:00 to 17:00 UK time.

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