Publications

Ashton, James J., et al. "16S sequencing and functional analysis of the fecal microbiome during treatment of newly diagnosed pediatric inflammatory bowel disease." Medicine, vol. 96, no. 26, 2017, e7347.

This study utilised 16S rRNA sequencing to analyse faecal microbiome changes in children undergoing treatment for newly diagnosed inflammatory bowel disease (IBD), revealing significant microbial composition shifts associated with disease activity and treatment response.

Seaby, Eleanor G., et al. "A gene pathogenicity tool 'GenePy' identifies missed biallelic diagnoses in the 100,000 Genomes Project." Genetics in Medicine, vol. 26, no. 4, 2024, p. 101073.

The authors introduced 'GenePy', a tool designed to assess gene pathogenicity, which successfully identified previously overlooked biallelic diagnoses in the 100,000 Genomes Project, enhancing diagnostic accuracy in genomic medicine.

Gasparetto, Marco, et al. "An Umbrella Review of the Effectiveness of Digital Technologies for the Management of Inflammatory Bowel Disease." Available at SSRN 4740403, 2024.

This umbrella review evaluated the efficacy of various digital technologies in managing IBD, concluding that digital interventions can improve patient outcomes through enhanced disease monitoring and patient engagement.

Ashton, James J., et al. "Analysis and hierarchical clustering of blood results before diagnosis in paediatric inflammatory bowel disease." Inflammatory Bowel Diseases, vol. 26, no. 3, 2020, pp. 469-475.

By analysing and hierarchically clustering pre-diagnostic blood results, this study identified distinct biomarker patterns that could facilitate earlier detection of paediatric IBD.

Ashton, James J., et al. "Analysis and interpretation of the human microbiome." Inflammatory Bowel Diseases, vol. 22, no. 7, 2016, pp. 1713-1722.

The paper discusses methodologies for analysing and interpreting human microbiome data, emphasizing the importance of understanding microbial contributions to IBD pathogenesis.

Ashton, James J., and R. Mark Beattie. "Anti‐TNF therapy and intestinal resections in Crohn's disease—are we just delaying the inevitable?" Alimentary Pharmacology & Therapeutics, vol. 50, no. 7, 2019.

The authors debate whether anti-TNF therapy in Crohn's disease merely postpones the need for surgical intervention, suggesting a need for strategies that modify disease progression.

Brooks-Warburton, Johanne, et al. "Artificial intelligence and inflammatory bowel disease: practicalities and future prospects." Frontline Gastroenterology, vol. 13, no. 4, 2022, pp. 325-331.

This article explores the application of artificial intelligence in IBD management, highlighting current practical uses and potential future developments in personalised care.

Ashton, James J., et al. "Beyond bedside measures of malnutrition in paediatric Crohn's disease–Should we be thinking of sarcopenia." Clinical Nutrition, vol. 39, no. 6, 2020, pp. 1639-1642.

The study advocates for assessing sarcopenia, or muscle loss, in paediatric Crohn's disease patients, suggesting it may be a more sensitive indicator of malnutrition than traditional bedside measures.

Ashton, James J., et al. "Bioelectrical spectroscopy impedance phase angle is not associated with nutritional status in a stable cohort of paediatric inflammatory bowel disease patients." Clinical Nutrition ESPEN, vol. 44, 2021, pp. 276-281.

Research findings indicate that bioelectrical impedance phase angle does not correlate with nutritional status in stable paediatric IBD patients, questioning its utility as a nutritional assessment tool in this population.

Ashton, James J., et al. "Challenges in chronic paediatric disease during the COVID-19 pandemic: diagnosis and management of inflammatory bowel disease in children." Archives of Disease in Childhood, vol. 105, no. 7, 2020, p. 706.

This article discusses the difficulties encountered in diagnosing and managing paediatric IBD during the COVID-19 pandemic, including delays in diagnosis and modifications to treatment protocols.

Barnes, Claire, et al. "Children and young people with inflammatory bowel disease attend less school than their healthy peers." Archives of Disease in Childhood, vol. 105, no. 7, 2020, pp. 671-676.

This study found that children and adolescents with inflammatory bowel disease (IBD) have higher rates of school absenteeism compared to their healthy counterparts, highlighting the need for supportive educational interventions.

Mossotto, Enrico, et al. "Classification of paediatric inflammatory bowel disease using machine learning." Scientific Reports, vol. 7, no. 1, 2017, p. 2427.

The authors developed a machine learning model to classify paediatric IBD subtypes, achieving high accuracy and demonstrating the potential of computational approaches in disease diagnosis.

Ashton, James J., et al. "Colectomy in pediatric ulcerative colitis: a single center experience of indications, outcomes, and complications." Journal of Pediatric Surgery, vol. 51, no. 2, 2016, pp. 277-281.

This retrospective study analysed indications, outcomes, and complications of colectomy in children with ulcerative colitis, providing insights into surgical decision-making and patient prognosis.

Takahashi, Shinichi, et al. "De novo and rare mutations in the HSPA1L heat shock gene associated with inflammatory bowel disease." Genome Medicine, vol. 9, 2017, p. 29.

The research identified novel mutations in the HSPA1L gene linked to IBD, suggesting a potential role of heat shock proteins in disease pathogenesis.

Ashton, James J., et al. "Deleterious genetic variation across the NOD signaling pathway is associated with reduced NFKB signaling transcription and upregulation of alternative inflammatory transcripts in pediatric inflammatory bowel disease." Inflammatory Bowel Diseases, vol. 28, no. 6, 2022, pp. 912-922.

The study found that harmful variations in the NOD signalling pathway correlate with decreased NFKB transcription and increased expression of alternative inflammatory pathways in paediatric IBD patients.

Ashton, James J., et al. "Endoscopic and histological assessment of paediatric inflammatory bowel disease over a 3-year follow-up period." Journal of Pediatric Gastroenterology and Nutrition, vol. 66, no. 3, 2018, pp. 402-409.

Over a three-year follow-up, discrepancies between endoscopic and histological assessments in paediatric IBD were observed, emphasising the importance of comprehensive evaluation methods.

Ashton, James J., et al. "Endoscopic versus histological disease extent at presentation of paediatric inflammatory bowel disease." Journal of Pediatric Gastroenterology and Nutrition, vol. 62, no. 2, 2016, pp. 246-251.

This study compared endoscopic and histological disease extents at diagnosis in paediatric IBD patients, finding significant differences that could impact disease classification and management.

Mossotto, Enrico, et al. "Evidence of a genetically driven metabolomic signature in actively inflamed Crohn’s disease." Scientific Reports, vol. 12, no. 1, 2022, p. 14101.

The authors identified a metabolomic signature associated with active inflammation in Crohn’s disease, suggesting a genetic basis for metabolic alterations in the disease.

Ashton, James J., et al. "Exclusive enteral nutrition in Crohn's disease: evidence and practicalities." Clinical Nutrition, vol. 38, no. 1, 2019, pp. 80-89.

This review discusses the evidence supporting exclusive enteral nutrition as a treatment for Crohn's disease and provides practical guidance for its implementation.

Andreoletti, Gaia, et al. "Exome analysis of patients with concurrent pediatric inflammatory bowel disease and autoimmune disease." Inflammatory Bowel Diseases, vol. 21, no. 6, 2015, pp. 1229-1236. 

Exome sequencing of paediatric patients with both IBD and autoimmune diseases revealed shared genetic variants, indicating potential common pathways in their pathogenesis.

Coelho, Tracy, et al. "Expression profile of the matricellular protein periostin in paediatric inflammatory bowel disease." Scientific Reports, vol. 11, no. 1, 2021, p. 6194.

The study examined periostin expression in paediatric IBD patients, finding elevated levels that may contribute to disease pathology and serve as a potential biomarker.

Ashton, James J., and R. Mark Beattie. "Faecal Calprotectin: What Does This Mean for the Paediatric Inflammatory Bowel Disease Phenotype?" Journal of Pediatric Gastroenterology and Nutrition, vol. 66, no. 4, 2018, e115.

The authors discuss the implications of faecal calprotectin levels in paediatric IBD, suggesting its utility in assessing disease phenotype and monitoring inflammation.

Mossotto, Enrico, et al. "GenePy—a score for estimating gene pathogenicity in individuals using next-generation sequencing data." BMC Bioinformatics, vol. 20, 2019, p. 254.

The paper introduces 'GenePy', a scoring system designed to estimate gene pathogenicity from next generation sequencing data, aiding in the interpretation of genetic variants.

Coelho, Tracy, et al. "Genes implicated in thiopurine-induced toxicity: Comparing TPMT enzyme activity with clinical phenotype and exome data in a paediatric IBD cohort." Scientific Reports, vol. 6, 2016, p. 34658.

This research compares TPMT enzyme activity with clinical phenotypes and exome data to identify genes associated with thiopurine toxicity in paediatric IBD patients.

Ashton, James J., et al. "Genetic sequencing of pediatric patients identifies mutations in monogenic inflammatory bowel disease genes that translate to distinct clinical phenotypes." Clinical and Translational Gastroenterology, vol. 11, no. 2, 2020, e00129.

 Genetic sequencing in paediatric IBD patients uncovered mutations in monogenic disease genes, correlating with specific clinical phenotypes and informing personalised treatment approaches.

Ashton, James J., et al. "Growth failure is rare in a contemporary cohort of paediatric inflammatory bowel disease patients." Acta Paediatrica, vol. 110, no. 1, 2021, pp. 326-334.

The study reports that growth failure is uncommon in modern pediatric IBD cohorts, likely due to improved disease management and nutritional support.

Ashton, James J., et al. "Ileal transcriptomic analysis in paediatric Crohn's disease reveals IL17- and NOD-signalling expression signatures in treatment-naïve patients and identifies epithelial cells driving differentially expressed genes." Journal of Crohn's and Colitis, vol. 15, no. 5, 2021, pp. 774-786.

This study conducted transcriptomic analysis on ileal tissue from treatment-naïve paediatric Crohn's disease patients, identifying significant upregulation of genes involved in IL17, NOD, and Oncostatin-M signalling pathways. The findings suggest that specific epithelial cell subsets expressing antimicrobial genes may drive these differential expression patterns, contributing to disease pathogenesis.

Coelho, Tracy, et al. "Immuno-genomic profiling of patients with inflammatory bowel disease: a systematic review of genetic and functional in vivo studies of implicated genes." Inflammatory Bowel Diseases, vol. 20, no. 10, 2014, pp. 1813-1819.

This systematic review examines genetic and functional in vivo studies related to inflammatory bowel disease (IBD), highlighting key genes implicated in disease pathogenesis. The findings underscore the complex genetic architecture of IBD and the importance of integrating genomic data to understand disease mechanisms.

Coelho, Tracy, et al. "Immunological profiling of paediatric inflammatory bowel disease using unsupervised machine learning." Journal of Pediatric Gastroenterology and Nutrition, vol. 70, no. 6, 2020, pp. 833-840.

The study employs unsupervised machine learning to analyse immunological data from paediatric IBD patients, identifying distinct immune profiles associated with different disease subtypes. These insights may inform personalised therapeutic strategies in paediatric IBD management.

Ashton, James J., et al. "Impact of COVID-19 on diagnosis and management of paediatric inflammatory bowel disease during lockdown: a UK nationwide study." Archives of Disease in Childhood, vol. 105, no. 12, 2020, pp. 1186-1191. 

This nationwide UK study assesses the effects of the COVID-19 lockdown on the diagnosis and management of paediatric IBD, revealing delays in diagnosis and alterations in treatment approaches. The findings highlight the need for adaptive healthcare strategies during pandemics to ensure timely care for chronic conditions.

Maclean, Abbie, et al. "Impact of COVID-19 on the diagnosis, assessment and management of children with inflammatory bowel disease in the UK: implications for practice." BMJ Paediatrics Open, vol. 4, no. 1, 2020, e000786.

 The article discusses the challenges and adaptations in diagnosing and managing paediatric IBD during the COVID-19 pandemic in the UK. It emphasizes the importance of maintaining essential services and developing contingency plans to support affected children during such crises.

Klomberg, Renz CW, et al. "Improved Clinical Outcomes With Early Anti-Tumour Necrosis Factor Alpha Therapy in Children With Newly Diagnosed Crohn’s Disease: Real-world Data from the International Prospective PIBD-SETQuality Inception Cohort Study." Journal of Crohn's and Colitis, vol. 18, no. 5, 2024, pp. 738-750.

This international cohort study demonstrates that early initiation of anti-TNFα therapy in children with newly diagnosed Crohn's disease leads to improved clinical outcomes. The findings support the consideration of early biologic intervention to optimize disease management in paediatric patients.

Ashton, James J., and R. Mark Beattie. "Improving remission rates in newly diagnosed paediatric ulcerative colitis." The Lancet Gastroenterology & Hepatology, vol. 2, no. 12, 2017, pp. 838-839.

The authors discuss strategies to enhance remission rates in children newly diagnosed with ulcerative colitis, emphasizing the importance of early and effective therapeutic interventions. They advocate for personalised treatment approaches to achieve better disease control.

Ashton, James J., et al. "Incidence and prevalence of paediatric inflammatory bowel disease continues to increase in the south of England." Journal of Pediatric Gastroenterology and Nutrition, vol. 75, no. 2, 2022, e20-e24.

This study reports a continued rise in both incidence and prevalence of paediatric IBD in the south of England. The increasing trend underscores the need for enhanced healthcare resources and research to address the growing burden of paediatric IBD.

Ashton, James J., et al. "Increased prevalence of anti‐TNF therapy in paediatric inflammatory bowel disease is associated with a decline in surgical resections during childhood." Alimentary Pharmacology & Therapeutics, vol. 49, no. 4, 2019, pp. 398-407.

The research indicates that the heightened use of anti-TNF therapy in paediatric IBD correlates with a reduction in the need for surgical interventions during childhood. This suggests that biologic treatments may alter the disease course, reducing surgical requirements.

Ashton, James J., et al. "Inflammatory bowel disease: long-term therapeutic challenges." Expert Review of Gastroenterology & Hepatology, vol. 13, no. 11, 2019, pp. 1049-1063.

The article reviews the long-term therapeutic challenges in managing IBD, including issues related to treatment efficacy, safety, and patient adherence. It highlights the need for ongoing research to develop more effective and sustainable treatment strategies.

Ashton, James J., and R. Mark Beattie. "Inflammatory bowel disease: recent developments." Archives of Disease in Childhood, vol. 109, no. 5, 2024, pp. 370-376. 

This review summarises recent advancements in the understanding and management of paediatric IBD, covering topics such as novel therapeutic agents, biomarkers, and insights into disease pathogenesis. The authors emphasise the importance of translating these developments into clinical practice.

Ashton, James J., et al. "Infliximab at diagnosis: Moving towards personalisation in paediatric inflammatory bowel disease." Gut, vol. 71, no. 1, 2022, pp. 2-3. 

The authors discuss the potential benefits of initiating infliximab therapy at the time of diagnosis in paediatric IBD patients, suggesting that early biologic intervention may lead to improved outcomes. They advocate for a personalised approach to treatment decisions.

Ashton, James J., et al. "Intestinal inflammation and extraintestinal disease: understanding dynamic risk." Gastroenterology, 2024.

This article explores the relationship between intestinal inflammation in IBD and the development of extraintestinal manifestations, analysing dynamic risk factors. The findings aim to inform comprehensive management strategies addressing both intestinal and extraintestinal aspects of the disease.

Ashton, James J., et al. "Is the incidence of paediatric inflammatory bowel disease still increasing?" Archives of Disease in Childhood, vol. 103, no. 11, 2018, pp. 1093-1094.

The correspondence questions whether the incidence of paediatric IBD continues to rise, suggesting that recent data indicate a plateau in new cases. The authors call for ongoing surveillance to monitor trends and inform healthcare planning.

Cheng, Guo, et al. "Moving from GWAS signals to rare functional variation in inflammatory bowel disease through application of GenePy2 as a potential DNA biomarker." medRxiv, 2024.04.19.24306093, 2024.

This study introduces GenePy2.0, a weighted variant burden score applied to the UK Biobank phase 2 cohort to explore potential genomic biomarkers for inflammatory bowel disease (IBD). The findings suggest that GenePy2.0 effectively detects deleterious variations associated with IBD, highlighting its promise as a tool for genomic biomarker discovery.

Christodoulou, Katja, et al. "Next generation exome sequencing of paediatric inflammatory bowel disease patients identifies rare and novel variants in candidate genes." Gut, vol. 62, no. 7, 2013, pp. 977-984.

 This study utilises exome sequencing to identify rare and novel genetic variants in paediatric IBD patients, uncovering potential candidate genes associated with disease susceptibility. The findings enhance the understanding of the genetic architecture of paediatric IBD and may inform future diagnostic and therapeutic strategies.

Green, Zachary, et al. "NIMBUS study protocol: a single-centre feasibility study of non-invasive monitoring with bowel ultrasound in paediatric inflammatory bowel disease." BMJ Open, vol. 13, no. 12, 2023, e078675.

 The NIMBUS study outlines a protocol to assess the feasibility of using bowel ultrasound as a non-invasive monitoring tool for paediatric IBD. If successful, this approach could reduce the need for invasive procedures and improve disease monitoring in children.

Ashton, James J., et al. "NOD2 in Crohn’s disease—unfinished business." Journal of Crohn's and Colitis, vol. 17, no. 3, 2023, pp. 450-458.

This article reviews the role of NOD2 mutations in Crohn's disease, discussing their impact on disease pathogenesis and clinical outcomes. The authors highlight the need for further research to fully elucidate the mechanisms by which NOD2 influences disease and to develop targeted therapies.

Gavin, Joan, et al. "Nutritional support in paediatric Crohn's disease: outcome at 12 months." Acta Paediatrica, vol. 107, no. 1, 2018, pp. 156-162.

The study evaluates the outcomes of nutritional support strategies in children with Crohn's disease over a 12-month period. Results indicate that appropriate nutritional interventions can lead to significant improvements in growth parameters and disease activity.

Green, Zachary, et al. "Paediatric inflammatory bowel disease: an update on current practice." Paediatrics and Child Health, 2024.

This article provides an updated overview of current practices in the diagnosis and management of paediatric IBD, incorporating recent advancements in the field. The authors discuss emerging therapies, diagnostic tools, and the importance of a multidisciplinary approach to care.

Ashton, James J., et al. "Paediatric inflammatory bowel disease: improving early diagnosis." Archives of Disease in Childhood, vol. 103, no. 4, 2018, pp. 307-308.

 The authors discuss strategies to enhance early diagnosis of paediatric IBD, emphasising the importance of awareness among healthcare providers and the use of appropriate diagnostic tools. Early detection is crucial for initiating timely treatment and improving patient outcomes.

Ashton, James J., et al. "Paediatric inflammatory bowel disease—brief update on current practice." Paediatrics and Child Health, vol. 28, no. 11, 2018, pp. 507-514. 

This brief update summarises key aspects of current practice in managing paediatric IBD, including diagnostic criteria, treatment options, and the role of multidisciplinary care. The authors highlight recent developments and ongoing challenges in the field.

Gavin, Joan, et al. "Patient, parent and professional perception of the use of maintenance enteral nutrition in Paediatric Crohn's Disease." Acta Paediatrica, vol. 107, no. 12, 2018, pp. 2199-2206.

The study explores the perspectives of patients, parents, and healthcare professionals on the use of maintenance enteral nutrition in managing paediatric Crohn's disease. Findings reveal varying levels of acceptance and highlight the need for clear communication and support to optimize adherence.

Ashton, James J., and R. Mark Beattie. "Personalised therapy for inflammatory bowel disease." The Lancet, vol. 393, no. 10182, 2019, pp. 1672-1674. 

The authors advocate for personalised therapy approaches in IBD, emphasizing the potential benefits of tailoring treatment based on individual patient characteristics, including genetic, environmental, and microbial factors. Personalised therapy aims to improve efficacy and reduce adverse effects.

Ashton, James J., et al. "Personalising medicine in inflammatory bowel disease—current and future perspectives." Translational Pediatrics, vol. 8, no. 1, 2019, pp. 56-69.

This review discusses the current state and future directions of personalised medicine in IBD, focusing on the integration of genomic, transcriptomic, and microbiome data to inform individualized treatment strategies. The authors highlight the challenges and opportunities in implementing personalised approaches in clinical practice.

Coelho, Tracy, et al. "Pharmacogenomic assessment of genes implicated in thiopurine metabolism and toxicity in a UK cohort of pediatric patients with inflammatory bowel disease." Inflammatory Bowel Diseases, 2024, izae126.

 The study investigates the pharmacogenomics of thiopurine metabolism in paediatric IBD patients, identifying genetic variants associated with drug toxicity and response. The findings support the potential for pharmacogenomic testing to guide personalised thiopurine therapy and improve safety.

Green, Zachary, and James J. Ashton. "Prediction in Inflammatory Bowel Disease—Do the Answers Lie in Big Clinical Data?" Alimentary Pharmacology & Therapeutics, vol. 60, no. 11-12, 2024, pp. 1609-1610. 

The authors discuss the potential of big clinical data to improve prediction models in IBD, enabling better disease stratification and personalised treatment approaches. They highlight the importance of data integration and advanced analytics in harnessing the full potential of clinical data.

Ashton, James J., et al. "Prediction of Crohn’s disease stricturing phenotype using a NOD2-derived genomic biomarker." Inflammatory Bowel Diseases, vol. 29, no. 4, 2023, pp. 511-521. 

This study identifies a genomic biomarker derived from NOD2 variants that predicts the development of a stricturing phenotype in Crohn's disease patients. The biomarker may aid in early risk stratification and inform treatment decisions to prevent disease complications.

Ashton, James J., et al. "Presenting phenotype of paediatric inflammatory bowel disease in Wessex, Southern England 2010–2013." Acta Paediatrica, vol. 104, no. 8, 2015, pp. 831-837.

 The research characterizes the presenting phenotypes of paediatric IBD patients in Wessex, Southern England, between 2010 and 2013. The findings provide insights into disease patterns and may inform regional healthcare planning and resource allocation.

Green, Zachary, et al. "Recent developments in the assessment and management of inflammatory bowel disease in childhood: a narrative review." Translational Pediatrics, vol. 12, no. 10, 2023, pp. 1853-1865.

This narrative review focuses on recent advancements in diagnosing and managing paediatric inflammatory bowel disease (IBD), highlighting improved outcomes such as reduced surgical rates and better growth preservation. The authors discuss the integration of personalised therapy, sustainable healthcare practices, and enhanced treatment access as key areas for future optimization in paediatric IBD care

Coelho, Tracy, et al. "Reply: Predicting Adverse Events to Thiopurines in IBD: Are We a Step Closer?" Inflammatory Bowel Diseases, vol. 30, no. 10, 2024, pp. 1928-1930.

In this correspondence, the authors respond to discussions on predicting adverse events to thiopurine therapy in inflammatory bowel disease (IBD). They emphasize the importance of pharmacogenomic assessments to enhance patient safety and treatment efficacy.

Ashton, James J., et al. "Rising incidence of paediatric inflammatory bowel disease (PIBD) in Wessex, Southern England." Archives of Disease in Childhood, vol. 99, no. 7, 2014, pp. 659-664. 

This study reports a significant increase in the incidence of paediatric inflammatory bowel disease in Wessex, Southern England, over recent years. The findings highlight the need for enhanced healthcare resources and awareness to manage the growing patient population.

Stafford, Imogen S., et al. "Supervised machine learning classifies inflammatory bowel disease patients by subtype using whole exome sequencing data." Journal of Crohn's and Colitis, vol. 17, no. 10, 2023, pp. 1672-1680. 

The authors employ supervised machine learning techniques to classify inflammatory bowel disease patients into subtypes based on whole exome sequencing data. This approach demonstrates potential for improving diagnostic accuracy and personalised treatment strategies.

Green, Zachary, et al. "Sustained Increase in Paediatric Inflammatory Bowel Disease Incidence Across the South West United Kingdom Over the Last 10 Years." Inflammatory Bowel Diseases, 2024, izad302. 

This research documents a continuous rise in paediatric inflammatory bowel disease incidence in the Southwest UK over a decade. The study underscores the importance of ongoing surveillance and resource allocation to address this public health concern.

Bethell, George S., et al. "Temporal trends in ileoanal pouch surgery for paediatric onset ulcerative colitis in England from 1997 to 2015 using hospital episode statistics." Journal of Pediatric Surgery, vol. 57, no. 2, 2022, pp. 257-260. 

Analysing hospital episode statistics, the study examines trends in ileoanal pouch surgeries for paediatric-onset ulcerative colitis in England between 1997 and 2015. The findings reveal evolving surgical practices and outcomes over the study period.

Noble, Alexandra, et al. "The circulating methylome in childhood-onset inflammatory bowel disease." Journal of Crohn's and Colitis, 2024, jjae157. 

This study investigates the circulating methylome profiles in children with inflammatory bowel disease, identifying potential epigenetic biomarkers. The results suggest avenues for non-invasive diagnostics and insights into disease pathogenesis.

Ashton, James J., et al. "The genetics of the human leucocyte antigen region in inflammatory bowel disease." Alimentary Pharmacology & Therapeutics, vol. 50, no. 8, 2019, pp. 885-900. 

The authors review the role of the human leucocyte antigen (HLA) region in the genetic susceptibility to inflammatory bowel disease. They discuss associations between specific HLA alleles and disease subtypes, contributing to understanding disease mechanisms

Marino, Luise V., et al. "The impact of national lockdown on nutritional status of children with inflammatory bowel disease." Journal of Human Nutrition and Dietetics, vol. 34, no. 4, 2021, pp. 656-659. 

This study assesses the effects of a national lockdown on the nutritional status of children with inflammatory bowel disease. Findings indicate that lockdown measures may have adversely affected nutritional outcomes, highlighting the need for targeted interventions during such periods.

Ashton, James J., et al. "The importance of high-quality ‘big data’ in the application of artificial intelligence in inflammatory bowel disease." Frontline Gastroenterology, vol. 14, no. 3, 2023, pp. 258-262.

The authors discuss the critical role of high-quality big data in developing and applying artificial intelligence solutions for inflammatory bowel disease. They emphasise data accuracy, standardisation, and comprehensive datasets as essential components for successful AI integration.

Bethell, George S., et al. "The influence of the introduction of biologic agents on surgical intervention in paediatric inflammatory bowel disease." Journal of Pediatric Gastroenterology and Nutrition, vol. 75, no. 3, 2022, pp. 308-312.

This research evaluates how the introduction of biologic therapies has impacted surgical intervention rates in paediatric inflammatory bowel disease. The study finds a correlation between increased biologic use and reduced surgical procedures, suggesting improved disease management.

Ashton, James J., et al. "The Pediatric Crohn Disease Morbidity Index (PCD-MI): Development of a Tool to Assess Long-Term Disease Burden Using a Data-Driven Approach." Journal of Pediatric Gastroenterology and Nutrition, vol. 77, no. 1, 2023, pp. 70-78.

The authors develop the Paediatric Crohn Disease Morbidity Index, a tool designed to assess long-term disease burden in children with Crohn's disease. Utilizing a data-driven approach, the index aims to facilitate comprehensive patient evaluations and inform treatment strategies.

Ashton, James, et al. "Therapeutic options for children and young people with moderate-to-severe ulcerative colitis." Frontline Gastroenterology, vol. 15, no. 5, 2024, pp. 387-394.

This article reviews current therapeutic options for paediatric patients with moderate-to-severe ulcerative colitis, including pharmacological and surgical interventions. The authors discuss treatment efficacy, safety profiles, and considerations for personalised care plans.

Ashton, James J., et al. "Transition services for paediatric inflammatory bowel disease: a multicentre study of practice in the United Kingdom." Journal of Pediatric Gastroenterology and Nutrition, vol. 73, no. 2, 2021, pp. 251-258.

Investigating transition services for paediatric inflammatory bowel disease across multiple centres in the UK, this study identifies variations in practice and areas for improvement. The findings advocate for standardised protocols to ensure seamless transition to adult care.

Ashton, James J., and R. Mark Beattie. "Treatment of active Crohn’s disease with an ordinary food-based diet that replicates exclusive enteral nutrition." Gastroenterology, vol. 157, no. 4, 2019, pp. 1160-1161.

 The authors explore the efficacy of a regular food-based diet designed to replicate the benefits of exclusive enteral nutrition in treating active Crohn's disease. Preliminary findings suggest this approach may offer a palatable and practical alternative for patients.

Ashton, James J., et al. "Therapeutic options for children and young people with moderate-to-severe ulcerative colitis." Frontline Gastroenterology, vol. 15, no. 5, 2024, pp. 387-394. 

This article reviews current therapeutic strategies for managing moderate-to-severe ulcerative colitis in paediatric patients. It discusses the efficacy and safety profiles of various treatments, including biologics and small molecules, to guide clinical decision-making.

Ashton, James J., et al. "TTC7A variants previously described to cause enteropathy are observed on a single haplotype and appear non-pathogenic in pediatric inflammatory bowel disease patients." Journal of Clinical Immunology, vol. 40, 2020, pp. 245-247. 

This study investigates TTC7A variants previously linked to enteropathy and finds them present on a single haplotype in paediatric inflammatory bowel disease patients. The findings suggest these variants may be non-pathogenic in this context, challenging prior assumptions.

Ashton, James J., et al. "Using machine learning to impact on long-term clinical care: principles, challenges, and practicalities." Pediatric Research, vol. 93, no. 2, 2023, pp. 324-333.

The authors discuss the application of machine learning in long-term clinical care, focusing on its principles, challenges, and practical considerations. They highlight the potential of machine learning to enhance patient outcomes through personalised medicine.

Auth, Marcus Karl-Heinz, et al. "Variation in access and prescription of vedolizumab and ustekinumab in paediatric patients with inflammatory bowel disease: a UK-wide study." Archives of Disease in Childhood, vol. 108, no. 12, 2023, pp. 994-998. 

This UK-wide study examines the variation in access and prescription of vedolizumab and ustekinumab among paediatric inflammatory bowel disease patients. The findings reveal disparities in treatment availability, underscoring the need for standardised care protocols.