Project overview
David Phillips Fellowship Award.
The objective of this research is to integrate approaches to the study of autonomously replicating cells in confined environments (here we consider malignancies and surface-attached bacteria). It is proposed that the evolutionary and ecological pressures for growth in these taxonomically very different systems are fundamentally the same, and thus can be addressed within the same experimental and conceptual framework. Processes of interest in tumorigenesis include i) destabilisation if the cancer cell genome, ii) viral-host cell interactions (in certain cancers) and iii) differentiation and death of cancer cells inside tumours. This project will integrate approaches to bacterial and tumour development by studying these processes in 3-dimensional structures in bacterial biofilms.
The objective of this research is to integrate approaches to the study of autonomously replicating cells in confined environments (here we consider malignancies and surface-attached bacteria). It is proposed that the evolutionary and ecological pressures for growth in these taxonomically very different systems are fundamentally the same, and thus can be addressed within the same experimental and conceptual framework. Processes of interest in tumorigenesis include i) destabilisation if the cancer cell genome, ii) viral-host cell interactions (in certain cancers) and iii) differentiation and death of cancer cells inside tumours. This project will integrate approaches to bacterial and tumour development by studying these processes in 3-dimensional structures in bacterial biofilms.
Staff
Lead researchers
Research outputs
Nicholas Barraud, David Schleheck, Janosch Klebensberger, Jeremy S. Webb, Daniel J. Hassett, Scott A. Rice & Staffan Kjelleberg,
2009, Journal of Bacteriology, 191(23), 7333-7342
DOI: 10.1128/JB.00975-09
Type: article
Tim C. R. Conibear, Samuel L. Collins & Jeremy S. Webb,
2009, PLoS ONE, 4(7), e6289
Type: article
David Schleheck, Nicolas Barraud, Frederick M. Ausubel, Janosch Klebensberger, Jeremy S. Webb, Diane McDougald, Scott A. Rice & Staffan Kjelleberg,
2009, PLoS ONE, 4(5), e5513
Type: article
Nicolas Barraud, Michael V. Storey, Zoe P. Moore, Jeremy S. Webb, Scott A. Rice & Staffan Kjelleberg,
2009, Microbial Biotechnology, 2(3), 370-378
Type: article