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Research project

Growth and development of bacterial 3-dimensional structures - A multidisciplinary approach.

  • Lead researcher:
    Professor Jeremy Webb
  • Research funder:
    Biotechnology & Biological Sciences Research Council
  • Status:
    Not active

Project overview

David Phillips Fellowship Award.
The objective of this research is to integrate approaches to the study of autonomously replicating cells in confined environments (here we consider malignancies and surface-attached bacteria). It is proposed that the evolutionary and ecological pressures for growth in these taxonomically very different systems are fundamentally the same, and thus can be addressed within the same experimental and conceptual framework. Processes of interest in tumorigenesis include i) destabilisation if the cancer cell genome, ii) viral-host cell interactions (in certain cancers) and iii) differentiation and death of cancer cells inside tumours. This project will integrate approaches to bacterial and tumour development by studying these processes in 3-dimensional structures in bacterial biofilms.

Staff

Lead researcher

Professor Jeremy Webb

Professor of Microbiology

Research interests

  • Microbial biofilms and their control
  • Adaptive biology and evolution of microorganisms
  • Biofilm-associated infection

Research outputs

Down-regulation of DNA mismatch repair enhances initiation and growth of neuroblastoma and brain tumour multicellular spheroids
Samuel L. Collins,
Rodolphe Hervé,
C.W. Keevil,
Jeremy P. Blaydes,
& Jeremy S. Webb
, 2011 , PLoS ONE , 6 (12) , e28123
DOI: 10.1371/journal.pone.0028123
Type: article
Risk of red queen dynamics in pneumococcal vaccine strategy
Johanna M.C. Jefferies,
Stuart Clarke,
Jeremy S. Webb,
& Alex R. Kraaijeveld
, 2011 , Trends in Microbiology , 19 (8) , 377--381
DOI: 10.1016/j.tim.2011.06.001
Type: article
Role of mutation in pseudomonas aeruginosa biofilm development.
Tim C. R. Conibear,
Samuel L. Collins,
& Jeremy S. Webb
, 2009 , PLoS ONE , 4 (7) , e6289
DOI: 10.1371/journal.pone.0006289
Type: article
Nitric oxide-mediated dispersal in single- and multi-species biofilms of clinically and industrially relevant microorganisms
Nicolas Barraud,
Michael V. Storey,
Zoe P. Moore,
Jeremy S. Webb,
Scott A. Rice,
& Staffan Kjelleberg
, 2009 , Microbial Biotechnology , 2 (3) , 370--378
DOI: 10.1111/j.1751-7915.2009.00098.x
Type: article
Nitric oxide signaling in pseudomonas aeruginosa biofilms mediates phosphodiesterase activity, decreased cyclic Di-GMP levels, and enhanced dispersal
Nicholas Barraud,
David Schleheck,
Janosch Klebensberger,
Jeremy S. Webb,
Daniel J. Hassett,
Scott A. Rice,
& Staffan Kjelleberg
, 2009 , Journal of Bacteriology , 191 (23) , 7333--7342
DOI: 10.1128/JB.00975-09
Type: article