Research project

Dr Vince O'Connor MRC TSE Highlight

Lead researchers:

Professor Vincent O'connor
Other researchers:

Emeritus Professor Hugh Perry
Research funder:

Medical Research Council
Status:

Not active

Staff

Lead researchers

Professor Vincent O'connor

Professor of Neurochemistry

Research interests

Molecular mechanism of synaptic function and dysfunction
Synaptic degeneration
Genetic models of synaptic and neuronal dysfunction

Connect with Vincent

Email: V.M.OConnor@soton.ac.uk

Other researchers

Emeritus Professor Hugh Perry MA, DPhil, FMedSci

Connect with Hugh

Email: V.H.Perry@soton.ac.uk

Research outputs

Analysis of the hippocampal proteome in ME7 prion disease reveals a predominant astrocytic signature and highlights the brain-restricted production of clusterin in chronic neurodegeneration

Ayodeji A Asuni, Bryony Gray, Joanne Bailey, Paul Skipp, V Hugh Perry & Vincent O'Connor, 2014, The Journal of Biological Chemistry, 289(7), 4532-4545

DOI: 10.1074/jbc.M113.502690

Type: article

Brain region specific pre-synaptic and post-synaptic degeneration are early components of neuropathology in prion disease

Zuzana Šišková, Richard A. Reynolds, Vincent O'Connor & V. Hugh Perry, 2013, PLoS ONE, 8(1)

DOI: 10.1371/journal.pone.0055004

Type: article

The role of activity in synaptic degeneration in a protein misfolding disease, prion disease

Matteo Caleo, Laura Restani, Eleonora Vannini, Zuzana Siskova, Hussain Al-Malki, Ruth Morgan, Vincent O'Connor & V Hugh Perry, 2012, PLoS ONE, 7(7), e41182

DOI: 10.1371/journal.pone.0041182

Type: article

The role of microglia in synaptic stripping and synaptic degeneration: a revised perspective

V. Hugh Perry & Vincent O'Connor, 2010, ASN Neuro, 2(5), e00047-[11pp]

DOI: 10.1042/AN20100024

Type: article

Morphological and functional abnormalities in mitochondria associated with synaptic degeneration in prion disease

Zuzana Sisková, Don Joseph Mahad, Carianne Pudney, Graham Campbell, Mark Cadogan, Ayodeji Asuni, Vincent O'Connor & Victor Hugh Perry, 2010, The American Journal of Pathology, 177(3), 1411-1421

DOI: 10.2353/ajpath.2010.091037

Type: article

Reactive hypertrophy of synaptic varicosities within the hippocampus of prion-infected mice

Zuzana Sisková, Nik K Sanyal, Adam Orban, Vincent O'Connor & V Hugh Perry, 2010, Biochemical Society Transactions, 38(2), 471-475

DOI: 10.1042/BST0380471

Type: article

Synaptopathy: dysfunction of synaptic function?

Nils Brose, Vincent O'Connor & Paul Skehel, 2010, Biochemical Society Transactions, 38(2), 443-444

DOI: 10.1042/BST0380443

Type: article