Research project

Investigating local determinants of outcome in human tuberculosis

Research groups:
Lead researcher:

Professor Paul Elkington
Other researchers:

Professor Hywel Morgan
Research funder:

Medical Research Council
Status:

Active

Project overview

This project investigates why some TB lesions progress while some regress by utilising single cell sequencing analysis of our 3D cell culture model of infection, along with engineered real-time readouts. Parallel analysis of clinical samples aims to identify new therapeutic targets.

Staff

Lead researcher

Professor Paul Elkington

Director of Inst. for Medical Innovation

Research interests

tuberculosis
immunopathology
diagnosis

Connect with Paul

Email: p.elkington@soton.ac.uk

Other researchers

Professor Hywel Morgan MBE

Professor of Bioelectronics

Connect with Hywel

Email: hm@ecs.soton.ac.uk

Collaborating research institutes, centres and groups

Institute for Life Sciences

We bring together interdisciplinary researchers with expertise across the themes of health and medicine, living systems, disruptive life technologies, and insights through data

IT Innovation

We develop and apply advances in IT technology, working with academic and industrial partners.

Digital Health and Biomedical Engineering

Our group brings together engineers and computer scientists to discover new approaches to diagnose and manage health and medical conditions.

Research outputs

Mycobacterium tuberculosis senses host Interferon-γ via the membrane protein MmpL10

Mohamed Ahmed,

Jared Mackenzie,

Liku Bekele Tezera,

Robert Krause,

Barry Truebody,

Diana Garay Baquero,

Andres Vallejo Pulido,

Katya Govender,

John Adamson,

Hayden Fisher,

Jonathan W. Essex,

Salah Mansour,

Paul Elkington,

Adrie J. C. Steyn,

& Alasdair Leslie

, 2022 , Communications Biology , 5 (1317)

DOI: 10.1038/s42003-022-04265-0

Type: article