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Research project

Investigating local determinants of outcome in human tuberculosis

Project overview

This project investigates why some TB lesions progress while some regress by utilising single cell sequencing analysis of our 3D cell culture model of infection, along with engineered real-time readouts. Parallel analysis of clinical samples aims to identify new therapeutic targets.


Lead researcher

Professor Paul Elkington

Director of Inst. for Medical Innovation

Research interests

  • tuberculosis
  • immunopathology
  • diagnosis
Connect with Paul
Other researchers

Professor Hywel Morgan MBE

Professor of Bioelectronics
Connect with Hywel

Collaborating research institutes, centres and groups

Research outputs

Mohamed Ahmed, Jared Mackenzie, Liku Bekele Tezera, Robert Krause, Barry Truebody, Diana Garay Baquero, Andres Vallejo Pulido, Katya Govender, John Adamson, Hayden Fisher, Jonathan W. Essex, Salah Mansour, Paul Elkington, Adrie J. C. Steyn & Alasdair Leslie, 2022, Communications Biology, 5(1317)
Type: article