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Research project

Investigating local determinants of outcome in human tuberculosis

Project overview

This project investigates why some TB lesions progress while some regress by utilising single cell sequencing analysis of our 3D cell culture model of infection, along with engineered real-time readouts. Parallel analysis of clinical samples aims to identify new therapeutic targets.


Lead researcher

Professor Paul Elkington

Professor of Respiratory Medicine

Research interests

  • tuberculosis
  • immunopathology

Connect with Paul

Other researchers

Professor Hywel Morgan MBE

Director of Inst for Life Sciences (Int)

Connect with Hywel

Collaborating research institutes, centres and groups

Research outputs

Mohamed Ahmed,
Jared Mackenzie,
Robert Krause,
Barry Truebody,
Katya Govender,
John Adamson,
Salah Mansour,
Adrie J. C. Steyn,
& Alasdair Leslie
, 2022 , Communications Biology , 5 (1317)
Type: article
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