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Research project

Investigating local determinants of outcome in human tuberculosis

Research groups:

Lead researcher:

Professor Paul Elkington

Other researchers:

Professor Hywel Morgan

Research funder:

Medical Research Council

Status:

Active

Project overview

This project investigates why some TB lesions progress while some regress by utilising single cell sequencing analysis of our 3D cell culture model of infection, along with engineered real-time readouts. Parallel analysis of clinical samples aims to identify new therapeutic targets.

Staff

Lead researcher

Professor Paul Elkington

Professor Paul Elkington

Professor of Respiratory Medicine

Research interests

tuberculosis
immunopathology

Connect with Paul

Email: p.elkington@soton.ac.uk

Other researchers

HM

Professor Hywel Morgan MBE

Director of Inst for Life Sciences (Int)

Connect with Hywel

Email: hm@ecs.soton.ac.uk

Collaborating research institutes, centres and groups

IT Innovation

We develop and apply advances in IT technology, working with academic and industrial partners.

Research outputs

Mycobacterium tuberculosis senses host Interferon-γ via the membrane protein MmpL10

Mohamed Ahmed,

Jared Mackenzie,

Liku Bekele Tezera,

Robert Krause,

Barry Truebody,

Diana Garay Baquero,

Andres Vallejo Pulido,

Katya Govender,

John Adamson,

Hayden Fisher,

Jonathan W. Essex,

Salah Mansour,

Paul Elkington,

Adrie J. C. Steyn,

& Alasdair Leslie

, 2022 , Communications Biology , 5 (1317)

DOI: 10.1038/s42003-022-04265-0

Type: article

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