Project overview
We propose that miRNAs play a critical role in the regulation of skeletal stem cell fate and function. We will determine the role of miRNAs in the maintenance of stem phenotype or enhancement of bone stem cell differentiation and mechanisms involved including cytoskeletal or epigenetic changes. We have recently shown that defined nanotopographies are capable of robustly regulating SSC fate in the absence of chemical cues. We will therefore use custom designed nanotopographies to control SSC phenotype (for instance, to induce osteogenesis or maintain SSC numbers) and examine how miRNAs affect stem cell responses through modulation of epigenetic, biochemical and biomechanical processes. This study will facilitate our understanding of the mechanisms involved in the regulation of skeletal stem cell fate and function.
Staff
Lead researcher
Research outputs
Michael Glinka,
, 2021
Type: bookChapter
C. Black,
M. C. de Andres,
L.J. White,
F.M. Savi,
O. Bas,
S. Saifzadeh,
J. Henkel,
A. Zannettino,
S. Gronthos,
M.A. Woodruff,
D.W. Hutmacher,
, 2020
, Biomaterials
, 247
Type: article
Andrew Greer,
Vitali Goriainov,
Cameron Russell Macgregor Black,
Lesley Turner,
R. Meek,
Karl Burgess,
Ian MacLaren,
Matthew J. Dalby,
& Nikolaj Gadegaard
, 2020
, ACS Applied Materials and Interfaces
, 12 (30) , 33541--33549
Type: article
Julia A. Wells,
, 2020
Type: bookChapter
Marta Pena Fernandez,
Cameron Black,
David Gibbs,
& Gianluca Tozzi
, 2020
, Materials
, 13 (1)
DOI: 10.3390/ma13010168
Type: article