Project overview
Systemic inflammation or infection gives rise to a fever and behavioural changes known as sickness behaviour. It has recently been shown that low levels of systemic inflammation not sufficient to cause a fever may impact on the brain, and transiently alter affective behaviour in mice and cognitive behaviour in man. We will investigate which aspects of cognition in mice are affected by subpyrogenic systemic inflammation and which cytokines are involved in signalling from the immune system to the brain. We will investigate whether vaccination, a low-grade systemic inflammatory challenge in man, impacts on cognition. We will investigate whether cytokine gene polymorphisms predict the impact of systemic inflammation on cognition. These studies will demonstrate how systemic inflammation may be of importance in our every day cognitive functioning and particularly in ageing.
Staff
Lead researchers
Research outputs
David J. Sanderson, Colm Cunningham, Robert M.J. Deacon, David M Bannerman, V. Hugh Perry & J. Nicholas P. Rawlins,
2009, Behavioural Brain Research, 201(1), 103-111
Type: article
J.L. Teeling & V.H. Perry,
2008, Neuroscience, 158(3), 1062-1073
Type: article
Romola. S. Bucks, Yori Gidron, Petra Harris, Jessica Teeling, Keith. A. Wesnes & V. Hugh Perry,
2008, Brain, Behavior and Immunity, 22(3), 399-407
Type: article
J.L. Teeling, L.M. Felton, R.M.J. Deacon, C. Cunningham, J.N.P. Rawlins & V.H. Perry,
2007, Brain, Behavior and Immunity, 21(6), 836-850
Type: article