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Research project

R Lewis BBSRC Amino acid transport through the placenta BB/I011315/1

Project overview

This interdisciplinary project investigated how amino acids cross the placenta to feed the fetus while it is growing in the womb. We combined laboratory experiments with mathematical modelling to provide new insight into how the placentas work and how membrane transporters carry amino acids across membranes. A key outcome of this work was the demonstration that simply increasing the levels of amino acids in the mothers blood will not effectively increase supply to the fetus.

Staff

Lead researcher

Professor Rohan Lewis PhD, FTPS

Prof of Placental&Integrative Physiology
Other researchers

Emeritus Professor Mark Hanson

Dr Bram Sengers

Associate Professor

Research outputs

Estrone sulphate uptake by the microvillous membrane of placental syncytiotrophoblast is coupled to glutamate efflux
Emma M Lofthouse,
Jane K Cleal,
Ita M O'Kelly,
Bram G Sengers,
& Rohan M Lewis
, 2018 , Biochemical and Biophysical Research Communications
DOI: 10.1016/j.bbrc.2018.10.074
Type: article
Computational modelling of placental amino acid transfer as an integrated system
N. Panitchob,
K.L. Widdows,
I.P. Crocker,
E.D. Johnstone,
C.P. Please,
C.P. Sibley,
J.D. Glazier,
R. Lewis,
& B. Sengers
, 2016 , Biochimica et Biophysica Acta (BBA) - Biomembranes , 1--31
DOI: 10.1016/j.bbamem.2016.03.028
Type: article
Computational modelling of amino acid exchange and facilitated transport in placental membrane vesicles
N. Pantichob,
K.L. Widdows,
I.P. Crocker,
Mark A. Hanson,
E.D. Johnstone,
C.P. Please,
C.P. Sibley,
J.D. Glazier,
R.M. Lewis,
& Bram G. Sengers
, 2015 , Journal of Theoretical Biology , 365 , 352--364
DOI: 10.1016/j.jtbi.2014.10.042
Type: article
Computational modelling of fatty acid transport in the human placenta
S. Perazzolo,
B. Hirschmugl,
C. Wadsack,
G. Desoye,
R Lewis,
& B. G. Sengers
, 2015
DOI: 10.1109/EMBC.2015.7320262
Type: conference
Glutamate cycling may drive organic anion transport on the basal membrane of human placental syncytiotrophoblast
Emma Lofthouse,
S. Brooks,
J. Cleal,
M. Hanson,
K. Poore,
Ita O'Kelly,
& R. Lewis
, 2015 , The Journal of Physiology , 593 (20) , 4549--4559
DOI: 10.1113/JP270743
Type: article
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