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Research project

R Lewis BBSRC Amino acid transport through the placenta BB/I011315/1

Project overview

This interdisciplinary project investigated how amino acids cross the placenta to feed the fetus while it is growing in the womb. We combined laboratory experiments with mathematical modelling to provide new insight into how the placentas work and how membrane transporters carry amino acids across membranes. A key outcome of this work was the demonstration that simply increasing the levels of amino acids in the mothers blood will not effectively increase supply to the fetus.

Staff

Lead researcher

Professor Rohan Lewis PhD, FTPS

Prof of Placental&Integrative Physiology
Other researchers

Dr Bram Sengers

Associate Professor

Research outputs

Emma M Lofthouse,
Jane K Cleal,
Ita M O'Kelly,
, 2018 , Biochemical and Biophysical Research Communications
Type: article
N. Panitchob,
K.L. Widdows,
I.P. Crocker,
E.D. Johnstone,
C.P. Please,
C.P. Sibley,
J.D. Glazier,
, 2016 , Biochimica et Biophysica Acta (BBA) - Biomembranes , 1--31
Type: article
N. Pantichob,
K.L. Widdows,
I.P. Crocker,
E.D. Johnstone,
C.P. Please,
C.P. Sibley,
J.D. Glazier,
, 2015 , Journal of Theoretical Biology , 365 , 352--364
Type: article
S. Perazzolo,
B. Hirschmugl,
C. Wadsack,
G. Desoye,
, 2015
Type: conference
Emma Lofthouse,
S. Brooks,
Ita O'Kelly,
, 2015 , The Journal of Physiology , 593 (20) , 4549--4559
Type: article
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