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Research project

R Lewis BBSRC Amino acid transport through the placenta BB/I011315/1

Project overview

This interdisciplinary project investigated how amino acids cross the placenta to feed the fetus while it is growing in the womb. We combined laboratory experiments with mathematical modelling to provide new insight into how the placentas work and how membrane transporters carry amino acids across membranes. A key outcome of this work was the demonstration that simply increasing the levels of amino acids in the mothers blood will not effectively increase supply to the fetus.

Staff

Lead researcher

Professor Rohan Lewis PhD, FTPS

Prof of Placental&Integrative Physiology

Connect with Rohan

Other researchers

Doctor Bram Sengers

Associate Professor

Connect with Bram

Research outputs

Computational modelling of placental amino acid transfer as an integrated system
N. Panitchob,
K.L. Widdows,
I.P. Crocker,
E.D. Johnstone,
C.P. Please,
C.P. Sibley,
J.D. Glazier,
R. Lewis,
& B. Sengers
, 2016 , Biochimica et Biophysica Acta (BBA) - Biomembranes , 1--31
DOI: 10.1016/j.bbamem.2016.03.028
Type: article
Computational modelling of amino acid exchange and facilitated transport in placental membrane vesicles
N. Pantichob,
K.L. Widdows,
I.P. Crocker,
Mark A. Hanson,
E.D. Johnstone,
C.P. Please,
C.P. Sibley,
J.D. Glazier,
R.M. Lewis,
& Bram G. Sengers
, 2015 , Journal of Theoretical Biology , 365 , 352--364
DOI: 10.1016/j.jtbi.2014.10.042
Type: article
Computational modelling of fatty acid transport in the human placenta
S. Perazzolo,
B. Hirschmugl,
C. Wadsack,
G. Desoye,
R Lewis,
& B. G. Sengers
, 2015
DOI: 10.1109/EMBC.2015.7320262
Type: conference
Integration of computational modeling with membrane transport studies reveals new insights into amino acid exchange transport mechanisms
Kate L. Widdows,
Nuttanont Panitchob,
Ian P. Crocker,
C.P. Please,
Mark A. Hanson,
Colin P. Sibley,
Edward D. Johnstone,
Bram G. Sengers,
Rohan M. Lewis,
& Jocelyn D. Glazier
, 2015 , The FASEB Journal , 29 , 2583--2594
DOI: 10.1096/fj.14-267773
Type: article
Phenylalanine transfer across the isolated perfused human placenta: an experimental and modelling investigation
E.M. Lofthouse,
S. Perazzolo,
S. Brooks,
I.P. Crocker,
J.D. Glazier,
E.D. Johnstone,
N. Panitchob,
C.P. Sibley,
K.L. Widdows,
B.G. Sengers,
& R.M. Lewis
, 2015 , American Journal of Physiology: Regulatory, Integrative and Comparative Physiology , 1--28
DOI: 10.1152/ajpregu.00405.2015
Type: article
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