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Research project

Andrographis paniculata for symptomatic relief of lower respiratory tract infection

Project overview

Respiratory tract infections (RTIs) are one of the most common reasons for GP consultations in the UK and 75% of all antibiotic prescribing arises in this setting. Research has suggested RTIs are predominantly caused by viruses, and that antibiotics are of very limited benefit in the majority of uncomplicated infections.

Currently in the UK, although herbs are readily available to the public and becoming increasingly popular, rigorous research into effectiveness, safety, and quality of herbal medicine is needed. One of the biggest motivations supporting this area of research, is the evolving global threat to public health of anti-microbial resistance (AMR). The reduction of antibiotic prescribing is now a major priority for the government and the NIHR.

It is clear that most of the time antibiotics have very limited impact on the symptoms from respiratory infections so the search is on to find alternative approaches to provide symptom relief. Andrographis appears both safe and helpful and probably has a role to play. In the future we hope this will lead to reduced reliance on antibiotic for these largely self-limiting illnesses.

Andrographis Paniculata (A. Paniculata, Chuān Xīn Lián) has traditionally been used as an antipyretic for relieving and reducing the severity and duration of symptoms of common colds and alleviating fever, cough and sore throats. The key component, known as the andrographolides, have shown anti-inflammatory, antiviral, anti-allergic, and immune-stimulatory activities.

The study suggests A. Paniculata appears beneficial and safe for relieving acute respiratory tract infections (ARTIs) symptoms and shortening time to symptom resolution

Staff

Lead researcher
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