Natural products biosynthesis: a complex cascade of catalytic steps in vitamin B6 biosynthesis is characterised by structures or reaction intermediates in the large PLP synthase complex
Time-resolved serial crystallography: experiments using microcrystals at room temperature, performed at synchrotrons and XFELs
Droplet microfluidics: producing homogenous microcrystal slurries for serial experiments
Joanne has research interests in health economic evaluation and decision modelling.
She has worked on a wide range of applied cost-effectiveness studies, including:
a review of newborn screening for inborn errors of metabolism;trials of diagnosis, patient education, structured decision-making and therapeutic interventions for arthritis and back pain;evaluations of diagnostic tests, preventive treatment and contact tracing for tuberculosis;a model of geographic allocation of resources for control of Chagas disease in Central America; andanalyses relating to the prevention and treatment of cardiovascular diseases.
Her methodological contributions include an MRC funded project on whole pathway modelling for NICE clinical guidelines and an economic perspective on test evaluation. She has also contributed to health outcome and quality of life studies.
